Abstract
C-cell tumors (medullary thyroid carcinoma) occur in humans and several other mammalian species. This tumor develops spontaneously with a high incidence (50%) in old Wag/Rij (Wistar-derived strain) rats. We have recently shown that calcitonin binding sites, which are present in the Wistar rats, are lost from renal medulla of the Wag/Rij rats before they reach the age of 1 month. In the present work, we investigated the distribution of calcitonin binding sites in the kidneys of first and second generation hybrids of Wistar x Wag/Rij rats. The absence of calcitonin binding sites from the renal medullas of 25% of F2 hybrids indicates that the deficiency is inherited in a Mendelian fashion and opens the way to establishing inbred strains lacking renal medullary calcitonin binding sites.
Footnotes
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↵1 This work was supported by Grant 6349 from A. R. C. (to F. T-L.).
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↵2 To whom requests for reprints should be addressed, at U.113 INSERM, C.H.U. Saint-Antoine, 27 rue Chaligny, 75571 Paris cédex 12, France.
- Received July 28, 1988.
- Revision received March 28, 1989.
- Accepted June 13, 1989.
- ©1989 American Association for Cancer Research.
Volume 49, Issue 18
