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Basic Sciences

Loss of Calcitonin Receptors: A Genetically Transmitted Defect in Rats with High Incidence of C-Cell Tumors

Z. Bouizar, S. Minvielle, F. Treilhou-Lahille, W. H. Rostene, E. Pidoux, N. Feingold, G. Milhaud and M. S. Moukhtar
Z. Bouizar
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S. Minvielle
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F. Treilhou-Lahille
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W. H. Rostene
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E. Pidoux
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N. Feingold
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G. Milhaud
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M. S. Moukhtar
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DOI:  Published September 1989
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Abstract

C-cell tumors (medullary thyroid carcinoma) occur in humans and several other mammalian species. This tumor develops spontaneously with a high incidence (50%) in old Wag/Rij (Wistar-derived strain) rats. We have recently shown that calcitonin binding sites, which are present in the Wistar rats, are lost from renal medulla of the Wag/Rij rats before they reach the age of 1 month. In the present work, we investigated the distribution of calcitonin binding sites in the kidneys of first and second generation hybrids of Wistar x Wag/Rij rats. The absence of calcitonin binding sites from the renal medullas of 25% of F2 hybrids indicates that the deficiency is inherited in a Mendelian fashion and opens the way to establishing inbred strains lacking renal medullary calcitonin binding sites.

Footnotes

  • ↵1 This work was supported by Grant 6349 from A. R. C. (to F. T-L.).

  • ↵2 To whom requests for reprints should be addressed, at U.113 INSERM, C.H.U. Saint-Antoine, 27 rue Chaligny, 75571 Paris cédex 12, France.

  • Received July 28, 1988.
  • Revision received March 28, 1989.
  • Accepted June 13, 1989.
  • ©1989 American Association for Cancer Research.
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September 1989
Volume 49, Issue 18
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Loss of Calcitonin Receptors: A Genetically Transmitted Defect in Rats with High Incidence of C-Cell Tumors
Z. Bouizar, S. Minvielle, F. Treilhou-Lahille, W. H. Rostene, E. Pidoux, N. Feingold, G. Milhaud and M. S. Moukhtar
Cancer Res September 15 1989 (49) (18) 5199-5202;

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Loss of Calcitonin Receptors: A Genetically Transmitted Defect in Rats with High Incidence of C-Cell Tumors
Z. Bouizar, S. Minvielle, F. Treilhou-Lahille, W. H. Rostene, E. Pidoux, N. Feingold, G. Milhaud and M. S. Moukhtar
Cancer Res September 15 1989 (49) (18) 5199-5202;
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