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Advances in Brief

Elevated Expression of Phosphatidylserine in the Outer Membrane Leaflet of Human Tumor Cells and Recognition by Activated Human Blood Monocytes

Teruhiro Utsugi, Alan J. Schroit, Jerome Connor, Corazon D. Bucana and Isaiah J. Fidler
Teruhiro Utsugi
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Alan J. Schroit
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Jerome Connor
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Corazon D. Bucana
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Isaiah J. Fidler
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DOI:  Published June 1991
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Abstract

We determined whether the presence of phosphatidylserine (PS) in the outer membrane leaflet of human tumor cells correlated with their recognition by activated human monocytes. Three tumorigenic cell lines, A375 melanoma and A431 and Colo-16 carcinomas, and a normal human epidermal keratinocyte line (NHEK) were incubated with monocytes activated to the tumoricidal state by γ-interferon and lipopolysaccharide. Activated human monocytes bound to and lysed all tumorigenic targets, while the nontumorigenic NHEK were neither bound nor killed. Semiquantitative analysis of PS in the outer leaflet of the cells revealed that the tumorigenic cells expressed 3–7-fold more PS than did the nontumorigenic NHEK. To determine whether enhanced PS expression on the tumor cells was responsible for their recognition by activated monocytes, NHEK were supplemented with exogenously supplied analogues of PS and phosphatidylcholine. PS-labeled NHEK but not phosphatidylcholine-labeled nor control NHEK bound to activated human monocytes. These results suggest a role for PS in monocyte recognition of tumor cells.

Footnotes

  • ↵1 Supported in part by Grants R35-CA 42107 and CA 47845 from the National Cancer Institute.

  • ↵2 To whom requests for reprints should be addressed, at the Department of Cell Biology, Box 173, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030.

  • Received March 18, 1991.
  • Accepted April 15, 1991.
  • ©1991 American Association for Cancer Research.
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June 1991
Volume 51, Issue 11
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Elevated Expression of Phosphatidylserine in the Outer Membrane Leaflet of Human Tumor Cells and Recognition by Activated Human Blood Monocytes
Teruhiro Utsugi, Alan J. Schroit, Jerome Connor, Corazon D. Bucana and Isaiah J. Fidler
Cancer Res June 1 1991 (51) (11) 3062-3066;

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Elevated Expression of Phosphatidylserine in the Outer Membrane Leaflet of Human Tumor Cells and Recognition by Activated Human Blood Monocytes
Teruhiro Utsugi, Alan J. Schroit, Jerome Connor, Corazon D. Bucana and Isaiah J. Fidler
Cancer Res June 1 1991 (51) (11) 3062-3066;
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