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Analysis of T-Cell Receptor α/β Variability in Lymphocytes Infiltrating a Melanoma Metastasis

Laurent Ferradini, Sergio Roman-Roman, José Azocar, Marie-Françoise Avril, Sophie Viel, Frédéric Triebel and Thierry Hercend
Laurent Ferradini
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Sergio Roman-Roman
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José Azocar
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Marie-Françoise Avril
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Sophie Viel
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Frédéric Triebel
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Thierry Hercend
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DOI:  Published September 1992
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Abstract

Multiple experimental and clinical studies have suggested that the immune system may, to some extent, control the development of melanomas. The presence of tumor-infiltrating lymphocytes could reflect an in situ immune reaction directed to the malignant cells. The characterization of T-cell receptor (TCR) expressed by tumor-infiltrating lymphocytes is one way to precisely analyze these local T-cell responses. In this study, we have assessed the TCR α/β variability in tumor-infiltrating lymphocytes from a subcutaneous metastasis of a melanoma patient. Using the anchored-polymerase chain reaction 268 TCR α and 266 TCR β chain transcripts have been cloned and sequenced. Their analysis shows that the T-cell infiltrate is extremely diverse, with no preferential TCR gene segment usage.

Footnotes

  • ↵1 Supported in part by ADRC Grants 2110 and 6338.

  • ↵2 To whom requests for reprints should be addressed, at Laboratoire d'Hémato-Immunologie, INSERM U333, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

  • Received January 15, 1992.
  • Accepted June 23, 1992.
  • ©1992 American Association for Cancer Research.
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September 1992
Volume 52, Issue 17
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Analysis of T-Cell Receptor α/β Variability in Lymphocytes Infiltrating a Melanoma Metastasis
Laurent Ferradini, Sergio Roman-Roman, José Azocar, Marie-Françoise Avril, Sophie Viel, Frédéric Triebel and Thierry Hercend
Cancer Res September 1 1992 (52) (17) 4649-4654;

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Analysis of T-Cell Receptor α/β Variability in Lymphocytes Infiltrating a Melanoma Metastasis
Laurent Ferradini, Sergio Roman-Roman, José Azocar, Marie-Françoise Avril, Sophie Viel, Frédéric Triebel and Thierry Hercend
Cancer Res September 1 1992 (52) (17) 4649-4654;
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