Table of Contents

Articles

• Advances in Brief

  Human B-Cell Immune Response to the Polymorphic Epithelial Mucin

  Aurelia Rughetti, Valeria Turchi, Cinzia Apollonj Ghetti, Giovanni Scambia, Pierluigi Benedetti Panici, Gabrio Roncucci, Salvatore Mancuso, Luigi Frati and Marianna Nuti

  Cancer Res June 1 1993 53 (11) 2457-2459;

  
  
• Advances in Brief

  Elevated Expression of the Human Mitochondrial Hinge Protein Gene in Cancer

  Alvin Y. Liu and Ragen C. Bradner

  Cancer Res June 1 1993 53 (11) 2460-2465;

  
  
• Advances in Brief

  Effect of Angiotensin II Induced Hypertension on Tumor Blood Flow and Interstitial Fluid Pressure

  Robert A. Zlotecki, Yves Boucher, Intae Lee, Laurence T. Baxter and Rakesh K. Jain

  Cancer Res June 1 1993 53 (11) 2466-2468;

  
  
• Advances in Brief

  Specific Tyrosinases Associated with Melanoma Replicative Senescence and Melanogenesis

  Mary Strasberg Rieber and Manuel Rieber

  Cancer Res June 1 1993 53 (11) 2469-2471;

  
  
• Advances in Brief

  Detection of ras Gene Mutations in Pancreatic Juice and Peripheral Blood of Patients with Pancreatic Adenocarcinoma

  Minoru Tada, Masao Omata, Shigenobu Kawai, Hiromitsu Saisho, Masao Ohto, Randall K. Saiki and John J. Sninsky

  Cancer Res June 1 1993 53 (11) 2472-2474;

  
  
• Advances in Brief

  Characterization of Insulin-like Growth Factor 1 in Human Primary Brain Tumors

  Ann-Christin Sandberg-Nordqvist, Pär-Axel Ståhlbom, Manfred Reinecke, V. Peter Collins, Hans von Holst and Vicki Sara

  Cancer Res June 1 1993 53 (11) 2475-2478;

  
  
• Advances in Brief

  Expression of the Biochemical Defect of Methionine Dependence in Fresh Patient Tumors in Primary Histoculture

  Hui-Yan Guo, Hector Herrera, Ami Groce and Robert M. Hoffman

  Cancer Res June 1 1993 53 (11) 2479-2483;

  
  
• Biochemistry and Biophysics

  Involvement of Protein Kinase C in the Regulation of Glycolipid Sulfotransferase Activity Levels in Renal Cell Carcinoma Cells

  Takahiko Kobayashi, Koichi Honke, Shinsei Gasa, Makoto Sugiura, Tamotsu Miyazaki, Ineo Ishizuka and Akira Makita

  Cancer Res June 1 1993 53 (11) 2484-2489;

  
  
• Biochemistry and Biophysics

  Cyclophosphamide Modulates Rat Hepatic Cytochrome P450 2C11 and Steroid 5α-Reductase Activity and Messenger RNA Levels through the Combined Action of Acrolein and Phosphoramide Mustard

  Thomas K. H. Chang and David J. Waxman

  Cancer Res June 1 1993 53 (11) 2490-2497;

  
  
• Carcinogenesis

  Transplacental Induction of Pancreas Tumors in Hamsters by Ethanol and the Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

  Hildegard M. Schüller, Rossanna Jorquera, Arthur Reichert and Andre Castonguay

  Cancer Res June 1 1993 53 (11) 2498-2501;

  
  
• Carcinogenesis

  Chemopreventive Effect of Oltipraz during Different Stages of Experimental Colon Carcinogenesis Induced by Azoxymethane in Male F344 Rats

  Chinthalapally V. Rao, Abraham Rivenson, Manish Katiwalla, Gary J. Kelloff and Bandaru S. Reddy

  Cancer Res June 1 1993 53 (11) 2502-2506;

  
  
• Carcinogenesis

  Nonpromoting 12-Deoxyphorbol 13-Esters Inhibit Phorbol 12-Myristate 13-Acetate Induced Tumor Promotion in CD-1 Mouse Skin

  Zoltan Szallasi, Ljubica Krsmanovic and Peter M. Blumberg

  Cancer Res June 1 1993 53 (11) 2507-2512;

  
  
• Clinical Investigations

  High Levels of Urokinase-type Plasminogen Activator and Its Inhibitor PAI-1 in Cytosolic Extracts of Breast Carcinomas Are Associated with Poor Prognosis

  Jan Grøndahl-Hansen, Ib Jarle Christensen, Christian Rosenquist, Nils Brünner, Henning T. Mouridsen, Keld Danø and Mogens Blichert-Toft

  Cancer Res June 1 1993 53 (11) 2513-2521;

  
  
• Endocrinology

  Effects of Insulin-like Growth Factor Receptor Inhibition on Human Melanomas in Culture and in Athymic Mice

  Richard W. Furlanetto, Shari E. Harwell and Raymond B. Baggs

  Cancer Res June 1 1993 53 (11) 2522-2526;

  
  
• Endocrinology

  Inhibition of Epidermal Growth Factor-like Growth Factor Secretion in Tracheobronchial Epithelial Cells by Vitamin A

  Lisa A. Miller, Ling Zhong Cheng and Reen Wu

  Cancer Res June 1 1993 53 (11) 2527-2533;

  
  
• Endocrinology

  Antitumor Effect of 22-Oxa-calcitriol, a Noncalcemic Analogue of Calcitriol, in Athymic Mice Implanted with Human Breast Carcinoma and Its Synergism with Tamoxifen

  Junko Abe-Hashimoto, Tomoko Kikuchi, Toshio Matsumoto, Yasuho Nishii, Etsuro Ogata and Kyoji Ikeda

  Cancer Res June 1 1993 53 (11) 2534-2537;

  
  
• Experimental Therapeutics

  Molecular Cloning and Characterization of the Complementary DNA for the M_r 85,000 Protein Overexpressed in Adriamycin-resistant Human Tumor Cells

  Yoshikazu Sugimoto, Hirofumi Hamada, Satomi Tsukahara, Kohji Noguchi, Kazuo Yamaguchi, Moriyuki Sato and Takashi Tsuruo

  Cancer Res June 1 1993 53 (11) 2538-2543;

  
  
• Experimental Therapeutics

  Thaliblastine, a Plant Alkaloid, Circumvents Multidrug Resistance by Direct Binding to P-Glycoprotein

  Guan Chen, Cheppail Ramachandran and Awtar Krishan

  Cancer Res June 1 1993 53 (11) 2544-2547;

  
  
• Experimental Therapeutics

  Effect of Photodynamic Therapy on the Endothelium-dependent Relaxation of Isolated Rat Aortas

  Miriam J. Gilissen, L. Elly A. van de Merbel-de Wit, Willem M. Star, Johan F. Koster and Wim Sluiter

  Cancer Res June 1 1993 53 (11) 2548-2552;

  
  
• Experimental Therapeutics

  Inhibition of Urokinase by 4-substituted Benzo[b]thiophene-2-carboxamidines: An Important New Class of Selective Synthetic Urokinase Inhibitor

  Murray J. Towle, Arthur Lee, Emmanuel C. Maduakor, C. Eric Schwartz, Alexander J. Bridges and Bruce A. Littlefield

  Cancer Res June 1 1993 53 (11) 2553-2559;

  
  
• Experimental Therapeutics

  Monoclonal Antibody Homodimers: Enhanced Antitumor Activity in Nude Mice

  Edith A. Wolff, George J. Schreiber, Wesley L. Cosand and Howard V. Raff

  Cancer Res June 1 1993 53 (11) 2560-2565;

  
  
• Experimental Therapeutics

  Inhibitory Effect of Angiogenesis Inhibitor TNP-470 on Tumor Growth and Metastasis of Human Cell Lines in Vitro and in Vivo

  Toru Yanase, Masaki Tamura, Kazuyuki Fujita, Shoji Kodama and Kenichi Tanaka

  Cancer Res June 1 1993 53 (11) 2566-2570;

  
  
• Experimental Therapeutics

  Phototoxicity, Redox Behavior, and Pharmacokinetics of Benzophenoxazine Analogues in EMT-6 Murine Sarcoma Cells

  Louis Cincotta, James W. Foley and Anthony H. Cincotta

  Cancer Res June 1 1993 53 (11) 2571-2580;

  
  
• Experimental Therapeutics

  Preclinical Antitumor Evaluation of Bis-acetato-ammine-dichloro-cyclohexylamine Platinum(IV): an Orally Active Platinum Drug

  Lloyd R. Kelland, George Abel, Mark J. McKeage, Mervyn Jones, Phyllis M. Goddard, Melanie Valenti, Barry A. Murrer and Kenneth R. Harrap

  Cancer Res June 1 1993 53 (11) 2581-2586;

  
  
• Experimental Therapeutics

  Pharmacokinetics of Piroxantrone in a Phase I Trial of Piroxantrone and Granulocyte-Colony Stimulating Factor

  Stacey L. Berg, Diane M. F. Savarese, Frank M. Balis, Andrea M. Denicoff, Marianne Hillig, Joyce A. O'Shaughnessy, David G. Poplack and Kenneth H. Cowan

  Cancer Res June 1 1993 53 (11) 2587-2590;

  
  
• Experimental Therapeutics

  Overcoming Tumor Necrosis Factor and Drug Resistance of Human Tumor Cell Lines by Combination Treatment with Anti-Fas Antibody and Drugs or Toxins

  Hideki Morimoto, Shin Yonehara and Benjamin Bonavida

  Cancer Res June 1 1993 53 (11) 2591-2596;

  
  
• Experimental Therapeutics

  Human Interleukin 2 Analogues That Preferentially Bind the Intermediate-Affinity Interleukin 2 Receptor Lead to Reduced Secondary Cytokine Secretion: Implications for the Use of These Interleukin 2 Analogues in Cancer Immunotherapy

  Keith M. Heaton, Grace Ju and Elizabeth A. Grimm

  Cancer Res June 1 1993 53 (11) 2597-2602;

  
  
• Experimental Therapeutics

  Cytokine Regulation of Human Monocyte Differentiation in Vitro: The Tumor-Cytotoxic Phenotype Induced by Macrophage Colony-stimulating Factor Is Developmentally Regulated by γ-Interferon

  David H. Munn and Elissa Armstrong

  Cancer Res June 1 1993 53 (11) 2603-2613;

  
  
• Experimental Therapeutics

  Base Transitions Are the Most Frequent Genetic Changes at P53 in Gastric Cancer

  Beatrice Renault, Marianne van den Broek, Riccardo Fodde, Juul Wijnen, Natalia S. Pellegata, Dino Amadori, P. Meera Khan and Guglielmina N. Ranzani

  Cancer Res June 1 1993 53 (11) 2614-2617;

  
  
• Experimental Therapeutics

  Transformation of NIH/3T3 Cells by Ornithine Decarboxylase Overexpression

  Jeffrey A. Moshier, Julie Dosescu, Magdalena Skunca and Gordon D. Luk

  Cancer Res June 1 1993 53 (11) 2618-2622;

  
  
• Experimental Therapeutics

  Sensitization of Tumor Cells to Tumor Necrosis Factor Action by the Protein Kinase Inhibitor Staurosporine

  Rudi Beyaert, Bart Vanhaesebroeck, Karen Heyninck, Elke Boone, Dirk De Valck, Klaus Schulze-Osthoff, Guy Haegeman, Frans Van Roy and Walter Fiers

  Cancer Res June 1 1993 53 (11) 2623-2630;

  
  
• Experimental Therapeutics

  Pathogenesis of Malignant Ascites Formation: Initiating Events That Lead to Fluid Accumulation

  Janice A. Nagy, Kemp T. Herzberg, Jane M. Dvorak and Harold F. Dvorak

  Cancer Res June 1 1993 53 (11) 2631-2643;

  
  
• Experimental Therapeutics

  Culture of Normal and Malignant Primary Human Mammary Epithelial Cells in a Physiological Manner Simulates in Vivo Growth Patterns and Allows Discrimination of Cell Type

  Lynn M. Bergstraesser and Sigmund A. Weitzman

  Cancer Res June 1 1993 53 (11) 2644-2654;

  
  
• Experimental Therapeutics

  Elevated High Mobility Group-I(Y) Gene Expression Is Associated with Progressive Transformation of Mouse Mammary Epithelial Cells

  Tracy G. Ram, Raymond Reeves and Howard L. Hosick

  Cancer Res June 1 1993 53 (11) 2655-2660;

  
  
• Experimental Therapeutics

  Laminin Regulates a Tumor Cell Chemotaxis Receptor through the Laminin-binding Integrin Subunit α₆

  Christine H. Blood and Bruce R. Zetter

  Cancer Res June 1 1993 53 (11) 2661-2666;

  
  
• Experimental Therapeutics

  Galaptin-mediated Adhesion of Human Ovarian Carcinoma A121 Cells and Detection of Cellular Galaptin-binding Glycoproteins

  David M. Skrincosky, Howard J. Allen and Ralph J. Bernacki

  Cancer Res June 1 1993 53 (11) 2667-2675;

  
  
• Experimental Therapeutics

  Nitric Oxide Mediates Kupffer Cell-induced Reduction of Mitochondrial Energization in Hepatoma Cells: A Comparison with Oxidative Burst

  Iwao Kurose, Soichiro Miura, Dai Fukumura, Yoshikazu Yonei, Hidetsugu Saito, Shinichiro Tada, Makoto Suematsu and Masaharu Tsuchiya

  Cancer Res June 1 1993 53 (11) 2676-2682;

  
  
• Meeting Report

  Second International Symposium on Cytostatic Drug Resistance

  Manfred Dietel

  Cancer Res June 1 1993 53 (11) 2683-2688;

  
  
• Meeting Report

  International Symposium on Polyamines in Cancer

  Kenji Nishioka

  Cancer Res June 1 1993 53 (11) 2689-2692;

  
  
• Articles

  Announcements

  Cancer Res June 1 1993 53 (11) 2693-2694;

  
  
• Articles

  Recent Deaths

  Cancer Res June 1 1993 53 (11) 2694-2694;

  
  
• Articles

  Calendar of Events

  Cancer Res June 1 1993 53 (11) 2694-2695;