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Expansion of the Epithelial Cell Proliferative Compartment and Frequency of Adenomatous Polyps in the Colon Correlate with the Strength of Family History of Colorectal Cancer

Hans Gerdes, J. Scott Gillin, Eliot Zimbalist, Carlos Urmacher, Martin Lipkin and Sidney J. Winawer
Hans Gerdes
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J. Scott Gillin
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Eliot Zimbalist
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Carlos Urmacher
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Martin Lipkin
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Sidney J. Winawer
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DOI:  Published January 1993
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Abstract

Expansion of the proliferative compartment of epithelial cells in colonic crypts and colonic adenomas have been described as phenotypic precursors to colon cancer in individuals affected with hereditary or sporadic colon cancer. This study measured the size of the proliferative compartment in colonic crypts and the frequency of adenomas in asymptomatic members of families having sporadic colorectal cancer. The subjects were divided into 2 groups according to the frequency of colorectal cancer in their families. A shift of the compartment of proliferating epithelial cells toward the lumenal surface of colonic crypts was seen in the group of subjects with a stronger family history of colorectal cancer, with significant differences in the numbers of proliferative cells in the upper and the lower crypt compartments (P < 0.05) and in the fraction of proliferative cells at the highest compartment at the lumenal surface of the crypts (P < 0.05). Cell proliferation patterns in normal-appearing mucosa of the 2 groups revealed no difference in whole crypt [3H]thymidine labeling index. Colonoscopic examination of the 56 subjects revealed an overall prevalence of adenomas of 21%; when stratified by frequency of colorectal cancer in their families, 3 of 22 subjects (14%) with a weaker family history had adenomas, while 9 of 34 (26%) with a stronger family history had adenomas. Thus, parallel abnormalities of colonic epithelial cell proliferation and neoplasia were seen in individuals with a family history of colorectal cancer, both of which were more pronounced with increasing strength of family history. This observation provides further evidence of relationships among these factors in the etiology of “sporadic” colorectal cancer.

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • Received August 17, 1992.
  • Accepted October 29, 1992.
  • ©1993 American Association for Cancer Research.
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January 1993
Volume 53, Issue 2
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Expansion of the Epithelial Cell Proliferative Compartment and Frequency of Adenomatous Polyps in the Colon Correlate with the Strength of Family History of Colorectal Cancer
Hans Gerdes, J. Scott Gillin, Eliot Zimbalist, Carlos Urmacher, Martin Lipkin and Sidney J. Winawer
Cancer Res January 15 1993 (53) (2) 279-282;

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Expansion of the Epithelial Cell Proliferative Compartment and Frequency of Adenomatous Polyps in the Colon Correlate with the Strength of Family History of Colorectal Cancer
Hans Gerdes, J. Scott Gillin, Eliot Zimbalist, Carlos Urmacher, Martin Lipkin and Sidney J. Winawer
Cancer Res January 15 1993 (53) (2) 279-282;
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