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Advances in Brief

Genetic Instability in Pancreatic Cancer and Poorly Differentiated Type of Gastric Cancer

Hye-Jung Han, Akio Yanagisawa, Yo Kato, Jae-Gahb Park and Yusuke Nakamura
Hye-Jung Han
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Akio Yanagisawa
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Yo Kato
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Jae-Gahb Park
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Yusuke Nakamura
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DOI:  Published November 1993
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Abstract

To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosomes 2, 3, and 17. A significantly high incidence of genetic instability was observed in pancreatic (6 of 9 tumors) and gastric cancers (22 of 57 cases). In other types of carcinoma, the incidence of replication error-positive cases was relatively low (3–16%). Among gastric carcinomas, significantly more replication error-positive cases were observed in the poorly differentiated types (16 of 25 cases) than in well differentiated types (3 of 18) (P = 0.0023 by Fisher's exact test). Our results suggested that genetic instability is likely to play an important role in development of pancreatic and gastric cancers, particularly poorly differentiated adenocarcinomas.

Footnotes

  • ↵1 This work was supported in part by the Ministry of Education, Culture and Science of Japan.

  • ↵2 To whom requests for reprints should be addressed.

  • Received August 9, 1993.
  • Accepted September 20, 1993.
  • ©1993 American Association for Cancer Research.
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November 1993
Volume 53, Issue 21
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Genetic Instability in Pancreatic Cancer and Poorly Differentiated Type of Gastric Cancer
Hye-Jung Han, Akio Yanagisawa, Yo Kato, Jae-Gahb Park and Yusuke Nakamura
Cancer Res November 1 1993 (53) (21) 5087-5089;

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Genetic Instability in Pancreatic Cancer and Poorly Differentiated Type of Gastric Cancer
Hye-Jung Han, Akio Yanagisawa, Yo Kato, Jae-Gahb Park and Yusuke Nakamura
Cancer Res November 1 1993 (53) (21) 5087-5089;
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