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Molecular Biology and Genetics

Absence of p53 Gene Mutations in Primary Neuroblastomas

Kyle Vogan, Mark Bernstein, Jean-Marie Leclerc, Linda Brisson, Josee Brossard, Garrett M. Brodeur, Jerry Pelletier and Philippe Gros
Kyle Vogan
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Mark Bernstein
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Jean-Marie Leclerc
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Linda Brisson
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Josee Brossard
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Garrett M. Brodeur
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Jerry Pelletier
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Philippe Gros
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DOI:  Published November 1993
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Abstract

Neuroblastoma is a common childhood malignancy of the sympathetic nervous system. Mutations in p53, a tumor suppressor gene located on the short arm of chromosome 17, are one of the most common genetic lesions in human cancers. The evidence for trisomies of 17q with loss of 17p in some cases of neuroblastoma led us to consider whether p53 mutations might contribute to the onset and progression of this malignancy. In this study, primary tumors from 38 neuroblastoma patients were screened for mutations within the coding exons of the p53 gene by single-strand conformation polymorphism analysis, and potential mutations were further analyzed by nucleotide sequence analysis. Previously described sequence variations were detected in many of the tumors, including a silent polymorphism at codon 213 (CGA to CGG) and the nontransforming Pro to Arg substitution at codon 72 (CCC to CGC). However, no other sequence variations were detected within the coding portions of the p53 gene. This finding suggests that p53 mutations do not contribute to the etiology of neuroblastoma and that the chromosome 17 alterations observed in neuroblastoma involve genes which are distinct from the p53 locus.

Footnotes

  • ↵1 This work was supported by Grant 376 to P. G. and Grant 2832 to J. P. from the National Cancer Institute of Canada and Grant MT-11354 to J. P. from the Medical Research Council of Canada. In addition, partial support was provided by Grants CA 46907, CA 05587, and CA 39771 from the NIH, Bethesda, MD. P. G. is a Chercheur Boursier of the Fonds de Recherche en Santé du Quebec and an International Research Scholar of the Howard Hughes Medical Institute. K. V. is supported by a predoctoral fellowship from the Howard Hughes Medical Institute.

  • ↵2 To whom requests for reprints should be addressed, at Department of Biochemistry, McGill University, 3655 Drummond St., Room 907, Montreal, Quebec, Canada, H3G 1Y6.

  • Received April 8, 1993.
  • Accepted August 26, 1993.
  • ©1993 American Association for Cancer Research.
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November 1993
Volume 53, Issue 21
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Absence of p53 Gene Mutations in Primary Neuroblastomas
Kyle Vogan, Mark Bernstein, Jean-Marie Leclerc, Linda Brisson, Josee Brossard, Garrett M. Brodeur, Jerry Pelletier and Philippe Gros
Cancer Res November 1 1993 (53) (21) 5269-5273;

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Absence of p53 Gene Mutations in Primary Neuroblastomas
Kyle Vogan, Mark Bernstein, Jean-Marie Leclerc, Linda Brisson, Josee Brossard, Garrett M. Brodeur, Jerry Pelletier and Philippe Gros
Cancer Res November 1 1993 (53) (21) 5269-5273;
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