Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • Log out
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Advances in Brief

Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion

Bernard Davies, Jonathan Waxman, Harpret Wasan, Paul Abel, Gordon Williams, Thomas Krausz, David Neal, David Thomas, Andrew Hanby and Frances Balkwill
Bernard Davies
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan Waxman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harpret Wasan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Abel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gordon Williams
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Krausz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Neal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Thomas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew Hanby
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frances Balkwill
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published November 1993
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

We have used quantitative zymography to measure levels of the type IV collagenases matrix metalloproteinase (MMP)-9 and MMP-2 in 42 biopsies of transitional cell carcinoma and in 7 biopsies of normal bladder. Mean levels of MMP-9 were significantly higher in tumor compared with normal samples (P = 0.08). Levels of MMP-9 and active MMP-2 increased with tumor grade (test for trend, P = 0.002 and P = 0.05, respectively). Levels of MMP-9 and activated MMP-2 were also higher in invasive tumors than in superficial ones (P = 0.001 and P = 0.008, respectively). In situ hybridization studies showed that the mRNAs for both MMP-2 and MMP-9 were located chiefly in the stroma rather than epithelial tumor cells and were concentrated at the interface between the two tissues.

Footnotes

    • Received July 22, 1993.
    • Accepted October 4, 1993.
    • ©1993 American Association for Cancer Research.
    PreviousNext
    Back to top
    November 1993
    Volume 53, Issue 22
    • Table of Contents
    • Table of Contents (PDF)
    • Back Matter (PDF)
    • Editorial Board (PDF)
    • Front Matter (PDF)

    Sign up for alerts

    Open full page PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for sharing this Cancer Research article.

    NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

    Enter multiple addresses on separate lines or separate them with commas.
    Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion
    (Your Name) has forwarded a page to you from Cancer Research
    (Your Name) thought you would be interested in this article in Cancer Research.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion
    Bernard Davies, Jonathan Waxman, Harpret Wasan, Paul Abel, Gordon Williams, Thomas Krausz, David Neal, David Thomas, Andrew Hanby and Frances Balkwill
    Cancer Res November 15 1993 (53) (22) 5365-5369;

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Levels of Matrix Metalloproteases in Bladder Cancer Correlate with Tumor Grade and Invasion
    Bernard Davies, Jonathan Waxman, Harpret Wasan, Paul Abel, Gordon Williams, Thomas Krausz, David Neal, David Thomas, Andrew Hanby and Frances Balkwill
    Cancer Res November 15 1993 (53) (22) 5365-5369;
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Jump to section

    • Article
    • Info & Metrics
    • PDF
    Advertisement

    Related Articles

    Cited By...

    More in this TOC Section

    Advances in Brief

    • Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion cDNA for Cancer Gene Immunotherapy
    • NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response
    • Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis
    Show more Advances in Brief

    Articles

    • Intersections between Blood Cell Development and Leukemia Genes
    • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
    • The Prizes
    Show more Articles
    • Home
    • Alerts
    • Feedback
    • Privacy Policy
    Facebook  Twitter  LinkedIn  YouTube  RSS

    Articles

    • Online First
    • Current Issue
    • Past Issues
    • Meeting Abstracts

    Info for

    • Authors
    • Subscribers
    • Advertisers
    • Librarians

    About Cancer Research

    • About the Journal
    • Editorial Board
    • Permissions
    • Submit a Manuscript
    AACR logo

    Copyright © 2021 by the American Association for Cancer Research.

    Cancer Research Online ISSN: 1538-7445
    Cancer Research Print ISSN: 0008-5472
    Journal of Cancer Research ISSN: 0099-7013
    American Journal of Cancer ISSN: 0099-7374

    Advertisement