Table of Contents

Articles

• Advances in Brief

  Controlled Release, Biodegradable Cytokine Depots: A New Approach in Cancer Vaccine Design

  Paul T. Golumbek, Rosa Azhari, Elizabeth M. Jaffee, Hyam I. Levitsky, Audrey Lazenby, Kam Leong and Drew M. Pardoll

  Cancer Res December 15 1993 53 (24) 5841-5844;

  
  
• Advances in Brief

  Hypoxic Mammalian Cell Radiosensitization by Nitric Oxide

  James B. Mitchell, David A. Wink, William DeGraff, Janet Gamson, Larry K. Keefer and Murali C. Krishna

  Cancer Res December 15 1993 53 (24) 5845-5848;

  
  
• Advances in Brief

  Genomic Instability in Colorectal Cancer: Relationship to Clinicopathological Variables and Family History

  Ragnhild A. Lothe, Päivi Peltomäki, Gunn Iren Meling, Lauri A. Aaltonen, Minna Nyström-Lahti, Lea Pylkkänen, Ketil Heimdal, Tone I. Andersen, Pål Møller, Torleiv O. Rognum, Sophie D. Fosså, Tor Haldorsen, Frøydis Langmark, Anton Brøgger, Albert de la Chapelle and Anne-Lise Børresen

  Cancer Res December 15 1993 53 (24) 5849-5852;

  
  
• Advances in Brief

  Microsatellite Instability Is Associated with Tumors That Characterize the Hereditary Non-Polyposis Colorectal Carcinoma Syndrome

  Päivi Peltomäki, Ragnhild A. Lothe, Lauri A. Aaltonen, Lea Pylkkänen, Minna Nyström-Lahti, Raquel Seruca, Leonor David, Ruth Holm, David Ryberg, Aage Haugen, Anton Brøgger, Anne-Lise Børresen and Albert de la Chapelle

  Cancer Res December 15 1993 53 (24) 5853-5855;

  
  
• Advances in Brief

  Genetic Predisposition to Transplacentally Induced Renal Cell Carcinomas in the Eker Rat

  Okio Hino, Hiroaki Mitani and Alfred G. Knudson

  Cancer Res December 15 1993 53 (24) 5856-5858;

  
  
• Advances in Brief

  EWS/Fli-1 Chimeric Protein Is a Transcriptional Activator

  Takatoshi Ohno, Veena N. Rao, E. Shyam and P. Reddy

  Cancer Res December 15 1993 53 (24) 5859-5863;

  
  
• Advances in Brief

  Antibody Response against the c-erbB-2 Oncoprotein in Breast Carcinoma Patients

  Serenella M. Pupa, Sylvie Ménard, Salvatore Andreola and Maria I. Colnaghi

  Cancer Res December 15 1993 53 (24) 5864-5866;

  
  
• Advances in Brief

  Imaging of Activated Natural Killer Cells in Mice by Positron Emission Tomography: Preferential Uptake in Tumors

  Robert J. Melder, Anna Liisa Brownell, Timothy M. Shoup, Gordon L. Brownell and Rakesh K. Jain

  Cancer Res December 15 1993 53 (24) 5867-5871;

  
  
• Advances in Brief

  Analysis of p53 Antibodies in Patients with Various Cancers Define B-Cell Epitopes of Human p53: Distribution on Primary Structure and Exposure on Protein Surface

  R. Lubin, B. Schlichtholz, D. Bengoufa, G. Zalcman, J. Trédaniel, A. Hirsch, C. Caron de Fromentel, C. Preudhomme, P. Fenaux, G. Fournier, P. Mangin, P. Laurent-Puig, G. Pelletier, M. Schlumberger, F. Desgrandchamps, A. Le Duc, J. P. Peyrat, N. Janin, B. Bressac and T. Soussi

  Cancer Res December 15 1993 53 (24) 5872-5876;

  
  
• Advances in Brief

  Antitumor Effect of Taxol-containing Liposomes in a Taxol-resistant Murine Tumor Model

  Amarnath Sharma, Eric Mayhew and Robert M. Straubinger

  Cancer Res December 15 1993 53 (24) 5877-5881;

  
  
• Advances in Brief

  An Exon 5 Deletion Variant of the Estrogen Receptor Frequently Coexpressed with Wild-Type Estrogen Receptor in Human Breast Cancer

  Qiu-Xia Zhang, Åke Borg and Suzanne A. W. Fuqua

  Cancer Res December 15 1993 53 (24) 5882-5884;

  
  
• Advances in Brief

  Characterization of a DNA Topoisomerase IIα Gene Rearrangement in Adriamycin-resistant P388 Leukemia: Expression of a Fusion Messenger RNA Transcript Encoding Topoisomerase IIα and the Retinoic Acid Receptor α Locus

  J. Peter McPherson, Greg A. Brown and Gerald J. Goldenberg

  Cancer Res December 15 1993 53 (24) 5885-5889;

  
  
• Special Lecture

  Prevention—Therapy—Basic Science and the Resolution of the Cancer Problem: Presidential Address

  Lee W. Wattenberg

  Cancer Res December 15 1993 53 (24) 5890-5896;

  
  
• Biochemistry and Biophysics

  Phospholipase Activation Triggers Apoptosis in Photosensitized Mouse Lymphoma Cells

  Munna L. Agarwal, Hedy E. Larkin, S. I. A. Zaidi, Hasan Mukhtar and Nancy L. Oleinick

  Cancer Res December 15 1993 53 (24) 5897-5902;

  
  
• Biochemistry and Biophysics

  Compensatory Occurrence of IV²Fucα,II³NeuAcα-Gg₄Cer and Human Fetal Antigen Lc₄Cer in Small Cell Carcinomas of the Human Lung

  Masao Iwamori, Kazushige Kiguchi, Shirou Nozawa, Setsuo Hirohashi, Yukio Shimosato and Yoshitaka Nagai

  Cancer Res December 15 1993 53 (24) 5903-5907;

  
  
• Biochemistry and Biophysics

  Interaction between Replication Forks and Topoisomerase I-DNA Cleavable Complexes: Studies in a Cell-free SV40 DNA Replication System

  Yeou-Ping Tsao, Alicia Russo, Gill Nyamuswa, Robert Silber and Leroy F. Liu

  Cancer Res December 15 1993 53 (24) 5908-5914;

  
  
• Clinical Investigations

  Pharmacokinetics of Recombinant Human Interleukin 3 Administered Subcutaneously and by Continuous Intravenous Infusion in Patients after Chemotherapy for Ovarian Cancer

  Bonne Biesma, Rolf Pokorny, John M. Kovarik, Frances A. Duffy, Pax H. B. Willemse, Nanno H. Mulder and Elisabeth G. E. de Vries

  Cancer Res December 15 1993 53 (24) 5915-5919;

  
  
• Clinical Investigations

  Tumor Detection with ¹³¹I-labeled Human Monoclonal antibody COU-1 in Patients with Suspected Colorectal Carcinoma

  Henrik Ditzel, Jens W. Rasmussen, Karin Erb, Per Borup-Christensen, Ingrid Titlestad, Erling Lassen, Claus Fenger, Ole Kronborg and Jens C. Jensenius

  Cancer Res December 15 1993 53 (24) 5920-5928;

  
  
• Clinical Investigations

  A Randomized Phase I Trial of Chronic Oral Etoposide with or without Granulocyte-Macrophage Colony-stimulating Factor in Patients with Advanced Malignancies

  Don W. Shaffer, Lon S. Smith, Howard A. Burris, Gary M. Clark, John R. Eckardt, Suzanne M. Fields, Geoffrey R. Weiss, David A. Rinaldi, Karen J. Bowen, John G. Kuhn and Daniel D. Von Hoff

  Cancer Res December 15 1993 53 (24) 5929-5933;

  
  
• Endocrinology

  Expression of a Constitutively Active Estrogen Receptor Variant in the Estrogen Receptor-negative BT-20 Human Breast Cancer Cell Line

  Carl G. Castles, Suzanne A. W. Fuqua, Diane M. Klotz and Steven M. Hill

  Cancer Res December 15 1993 53 (24) 5934-5939;

  
  
• Endocrinology

  Estradiol Induction of Retinoic Acid Receptors in Human Breast Cancer Cells

  Shaun D. Roman, Christopher J. Ormandy, David L. Manning, Roger W. Blamey, Robert I. Nicholson, Robert L. Sutherland and Christine L. Clarke

  Cancer Res December 15 1993 53 (24) 5940-5945;

  
  
• Experimental Therapeutics

  Teniposide-resistant CEM Cells, Which Express Mutant DNA Topoisomerase IIα, When Treated with Non-Complex-stabilizing Inhibitors of the Enzyme, Display No Cross-Resistance and Reveal Aberrant Functions of the Mutant Enzyme

  Mei Chen and William T. Beck

  Cancer Res December 15 1993 53 (24) 5946-5953;

  
  
• Experimental Therapeutics

  Pharmacokinetics of a Fluorescent Drug Using Laser-induced Fluorescence

  Joan K. Frisoli, Eugene G. Tudor, Thomas J. Flotte, Tayyaba Hasan, Thomas F. Deutsch and Kevin T. Schomacker

  Cancer Res December 15 1993 53 (24) 5954-5961;

  
  
• Experimental Therapeutics

  The Protective Role of Ammonium Trichloro(dioxoethylene-O,O′) tellurate in Combination with Several Cytotoxic Drugs Acting by Different Mechanisms of Action

  Yona Kalechman, Adi Shani, Iris Sotnik-Barkai, Michael Albeck and Benjamin Sredni

  Cancer Res December 15 1993 53 (24) 5962-5969;

  
  
• Experimental Therapeutics

  In Vitro Cytotoxicity, Protein Binding, Red Blood Cell Partitioning, and Biotransformation of Oxaliplatin

  L. Pendyala and P. J. Creaven

  Cancer Res December 15 1993 53 (24) 5970-5976;

  
  
• Experimental Therapeutics

  Flavonol-stimulated Efflux of 7,12-Dimethylbenz(a)anthracene in Multidrug-resistant Breast Cancer Cells

  James M. Phang, C. Michael Poore, Joanna Lopaczynska and Grace Chao Yeh

  Cancer Res December 15 1993 53 (24) 5977-5981;

  
  
• Experimental Therapeutics

  Sequential Impact of Tiazofurin and Ribavirin on the Enzymic Program of the Bone Marrow

  Noemi Prajda, Yuki Hata, Margit Abonyi, Radhey L. Singhal and George Weber

  Cancer Res December 15 1993 53 (24) 5982-5986;

  
  
• Experimental Therapeutics

  Intoplicine (RP 60475) and Its Derivatives, a New Class of Antitumor Agents Inhibiting Both Topoisomerase I and II Activities

  Jean-François Riou, Philippe Fossé, Chi Hung Nguyen, Annette Kragh Larsen, Marie-Christine Bissery, Lucile Grondard, Jean-Marie Saucier, Emile Bisagni and François Lavelle

  Cancer Res December 15 1993 53 (24) 5987-5993;

  
  
• Experimental Therapeutics

  Effects of Nonionic Detergents on P-Glycoprotein Drug Binding and Reversal of Multidrug Resistance

  Tracy Zordan-Nudo, Victor Ling, Zhi Liu and Elias Georges

  Cancer Res December 15 1993 53 (24) 5994-6000;

  
  
• Immunology

  Suppression of Stress Protein GRP78 Induction in Tumor B/C10ME Eliminates Resistance to Cell Mediated Cytotoxicity

  Shunji Sugawara, Kazuyoshi Takeda, Amy Lee and Gunther Dennert

  Cancer Res December 15 1993 53 (24) 6001-6005;

  
  
• Immunology

  1α,25-Dihydroxyvitamin D₃ plus γ-Interferon Blocks Lung Tumor Production of Granulocyte-Macrophage Colony-stimulating Factor and Induction of Immunosuppressor Cells

  M. Rita, I. Young, John Halpin, Jeannie Wang, Mark A. Wright, John Matthews and Annette Schmidt Pak

  Cancer Res December 15 1993 53 (24) 6006-6010;

  
  
• Molecular Biology and Genetics

  Complementation of the Radiosensitive Phenotype in Severe Combined Immunodeficient Mice by Human Chromosome 8

  Cordula U. Kirchgessner, Liana M. Tosto, Kim A. Biedermann, Mary Kovacs, Diana Araujo, Eric J. Stanbridge and J. Martin Brown

  Cancer Res December 15 1993 53 (24) 6011-6016;

  
  
• Molecular Biology and Genetics

  Annexin II Expression Is Regulated during Mammalian Cell Cycle

  Yungping Chiang, Martin H. Schneiderman and Jamboor K. Vishwanatha

  Cancer Res December 15 1993 53 (24) 6017-6021;

  
  
• Molecular Biology and Genetics

  Allelotype Analysis of Mouse Skin Tumors Using Polymorphic Microsatellites: Sequential Genetic Alterations on Chromosomes 6, 7, and 11

  Christopher J. Kemp, Frances Fee and Allan Balmain

  Cancer Res December 15 1993 53 (24) 6022-6027;

  
  
• Molecular Biology and Genetics

  Infrequency of MDM2 Gene Amplification in Pediatric Solid Tumors and Lack of Association with p53 Mutations in Adult Squamous Cell Carcinomas

  Pamela G. Waber, Jun Chen and Perry D. Nisen

  Cancer Res December 15 1993 53 (24) 6028-6030;

  
  
• Molecular Biology and Genetics

  Allelic Variation in the Dihydrofolate Reductase Gene at Amino Acid Position 95 Contributes to Antifolate Resistance in Chinese Hamster Cells

  Myounghee Yu and Peter W. Melera

  Cancer Res December 15 1993 53 (24) 6031-6035;

  
  
• Tumor Biology

  N-(4-Hydroxyphenyl)retinamide Induces Apoptosis of Malignant Hemopoietic Cell Lines Including Those Unresponsive to Retinoic Acid

  Domenico Delia, Antonella Aiello, Luciano Lombardi, Pier Giuseppe Pelicci, Francesco Grignani, Fausto Grignani, Franca Formelli, Sylvie Menard, Alberto Costa, Umberto Veronesi and Marco A. Pierotti

  Cancer Res December 15 1993 53 (24) 6036-6041;

  
  
• Tumor Biology

  Statistical Analysis of in Vivo Tumor Growth Experiments

  Daniel F. Heitjan, Andrea Manni and Richard J. Santen

  Cancer Res December 15 1993 53 (24) 6042-6050;

  
  
• Tumor Biology

  Inhibition of Invasion of HT1080 Sarcoma Cells Expressing Recombinant Plasminogen Activator Inhibitor 2

  Walter E. Laug, Xiang Rong Cao, Yan Bin Yu, Hiroyuki Shimada and Egbert K. O. Kruithof

  Cancer Res December 15 1993 53 (24) 6051-6057;

  
  
• Tumor Biology

  Z-4′,5′-Didehydro-5′-deoxy-5′-fluoroadenosine (MDL 28,842), an Irreversible Inhibitor of S-Adenosylhomocysteine Hydrolase, Suppresses Proliferation of Cultured Keratinocytes and Squamous Carcinoma Cell Lines

  Amy S. Paller, Sheryl L. Arnsmeier, Sandra H. Clark and Bernard L. Mirkin

  Cancer Res December 15 1993 53 (24) 6058-6060;

  
  
• Tumor Biology

  Expression of Calcylin in Human Melanocytic Lesions

  Marian A. J. Weterman, Goos N. P. van Muijen, Henri P. J. Bloemers and Dirk J. Ruiter

  Cancer Res December 15 1993 53 (24) 6061-6066;

  
  
• Virology

  Sequence Analysis of an Immunogenic and Neutralizing Domain of the Human T-Cell Lymphoma/Leukemia Virus Type I gp46 Surface Membrane Protein among Various Primate T-Cell Lymphoma/Leukemia Virus Isolates Including Those from a Patient with Both HTLV-I-associated Myelopathy and Adult T-Cell Leukemia

  Michael P. Sherman, Syamalima Dube, Timothy P. Spicer, Timothy D. Kane, Jayne L. Love, Nitin K. Saksena, Robert Iannone, Clarence J. Gibbs Jr., Richard Yanagihara, Dipak K. Dube and Bernard J. Poiesz

  Cancer Res December 15 1993 53 (24) 6067-6073;

  
  
• Letters to the Editor

  Correspondence re: M. J. Thun et al., Aspirin Use and Risk of Fatal Cancer. Cancer Res., 53: 1322–1327, 1993

  Zane N. Gaut

  Cancer Res December 15 1993 53 (24) 6074-6074;

  
  
• Letters to the Editor

  Correspondence re: A. M. Lynch et al., Intra- and Interindividual Variability in Systemic Exposure in Humans to 2-Amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, Carcinogens Present in Cooked Beef. Cancer Res., 52: 6216–6223, 1992

  Philippe Shubik

  Cancer Res December 15 1993 53 (24) 6075-6075;

  
  
• Letters to the Editor

  Correspondence re: A. M. Lynch et al., Intra- and Interindividual Variability in Systemic Exposure in Humans to 2-Amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, Carcinogens Present in Cooked Beef. Cancer Res., 52: 6216–6223, 1992 — Reply

  Anthony M. Lynch, Alan R. Boobis, Donald S. Davies, Stephen Murray and Nigel Gooderham

  Cancer Res December 15 1993 53 (24) 6075-6076;

  
  
• Articles

  Announcements

  Cancer Res December 15 1993 53 (24) 6077-6079;

  
  
• Articles

  Erratum

  Cancer Res December 15 1993 53 (24) 6079-6079;

  
  
• Articles

  Correction

  Cancer Res December 15 1993 53 (24) 6079-6079;

  
  
• Articles

  Acknowledgment to Reviewers

  Cancer Res December 15 1993 53 (24) 6080-6088;