Table of Contents

Articles

• Advances in Brief

  Role of Tyrosine Phosphorylation in Radiation-induced Activation of c-jun Protooncogene in Human Lymphohematopoietic Precursor Cells

  Heonjoo Park Chae, Lisa J. Jarvis and Fatih M. Uckun

  Cancer Res February 1 1993 53 (3) 447-451;

  
  
• Advances in Brief

  Screening for Germ Line p53 Mutations in Children with Malignant Tumors and a Family History of Cancer

  L. Brugières, M. Gardes, C. Moutou, A. Chompret, V. Meresse, A. Martin, N. Poisson, F. Flamant, C. Bonaïti-Pellié, J. Lemerle and J. Feunteun

  Cancer Res February 1 1993 53 (3) 452-455;

  
  
• Advances in Brief

  Delayed-Type Hypersensitivity Reactions to Tumor-associated Antigens in Colon Carcinoma Patients Immunized with an Autologous Tumor Cell/Bacillus Calmette-Guérin Vaccine

  Elisabeth Bloemena, Helen Gall, Janet H. Ransom, Nicholas Pomato, James H. Murray, Ebo Bos, Rik J. Scheper, Chris J. L. M. Meijer, Michael G. Hanna Jr. and Jan B. Vermorken

  Cancer Res February 1 1993 53 (3) 456-459;

  
  
• Advances in Brief

  DNA-Protein Cross-Links in Welders: Molecular Implications

  Max Costa, Anatoly Zhitkovich and Paolo Toniolo

  Cancer Res February 1 1993 53 (3) 460-463;

  
  
• Advances in Brief

  Interleukin 6 Stimulates the Production of Immunoreactive Endothelin 1 in Human Breast Cancer Cells

  Jun-ichi Yamashita, Michio Ogawa, Koichi Nomura, Shuichi Matsuo, Kazuo Inada, Shin-ichi Yamashita, Yasunari Nakashima, Tetsushi Saishoji, Sadamu Takano and Shoji Fujita

  Cancer Res February 1 1993 53 (3) 464-467;

  
  
• Advances in Brief

  p53 Abnormalities in Different Subtypes of Human Sarcomas

  Å. Andreassen, T. Øyjord, E. Hovig, R. Holm, V. A. Flørenes, J. M. Nesland, O. Myklebost, J. Høie, Ø. S. Bruland, A-L. Børresen and Ø. Fodstad

  Cancer Res February 1 1993 53 (3) 468-471;

  
  
• Advances in Brief

  Time Course of Induction of Metabolism of all-trans-Retinoic Acid and the Up-Regulation of Cellular Retinoic Acid-binding Protein

  Peter C. Adamson, John F. Boylan, Frank M. Balis, Robert F. Murphy, Karen A. Godwin, Lorraine J. Gudas and David G. Poplack

  Cancer Res February 1 1993 53 (3) 472-476;

  
  
• Public Issues

  Trends in Program Project Grant Funding at the National Cancer Institute

  Samuel Broder and Mary Cushing

  Cancer Res February 1 1993 53 (3) 477-484;

  
  
• Special Lecture

  Role of the BCR-ABL Oncogene in Human Leukemia: Fifteenth Richard and Hinda Rosenthal Foundation Award Lecture

  Owen N. Witte

  Cancer Res February 1 1993 53 (3) 485-489;

  
  
• Biochemistry and Biophysics

  Induction of Topoisomerase I-mediated DNA Cleavage by a New Indolocarbazole, ED-110

  Tomoko Yoshinari, Akihiro Yamada, Daisuke Uemura, Kazuhiro Nomura, Hiroharu Arakawa, Katsuhisa Kojiri, Eisaku Yoshida, Hiroyuki Suda and Akira Okura

  Cancer Res February 1 1993 53 (3) 490-494;

  
  
• Carcinogenesis

  Identification of Cellular Defect in UVS1, a UV-sensitive Chinese Hamster Ovary Mutant Cell Line

  Masayuki Numata, Hiroaki Hata, Tadahiro Shiomi, Tsukasa Matsunaga, Toshio Mori, Osamu Nikaido, Akira Yasui and Atsushi Oikawa

  Cancer Res February 1 1993 53 (3) 495-499;

  
  
• Carcinogenesis

  Clonal Analysis of the Expression of Multiple Transformation Phenotypes and Tumorigenicity by Morphologically Transformed 10T1/2 Cells

  Gary J. Smith, William N. Bell and Joe W. Grisham

  Cancer Res February 1 1993 53 (3) 500-508;

  
  
• Carcinogenesis

  Metabolic Activation of N-Hydroxy-2-aminofluorene and N-Hydroxy-2-acetylaminofluorene by Monomorphic N-Acetyltransferase (NAT1) and Polymorphic N-Acetyltransferase (NAT2) in Colon Cytosols of Syrian Hamsters Congenic at the NAT2 Locus

  David W. Hein, Mark A. Doll, Kevin Gray, Timothy D. Rustan and Ronald J. Ferguson

  Cancer Res February 1 1993 53 (3) 509-514;

  
  
• Carcinogenesis

  Transformation-induced Alterations in the Regulation of Tyrosine Aminotransferase Expression in Fetal Rat Hepatocytes: Changes in Hormone Inducibility and the DNase-hypersensitive Site

  George C. T. Yeoh and Christopher J. Fisher

  Cancer Res February 1 1993 53 (3) 515-522;

  
  
• Clinical Investigations

  Phase I and Pharmacokinetic Study of Taxotere (RP 56976) Administered as a 24-Hour Infusion

  D. Bissett, A. Setanoians, J. Cassidy, M. A. Graham, G. A. Chadwick, P. Wilson, V. Auzannet, N. Le Bail, S. B. Kaye and D. J. Kerr

  Cancer Res February 1 1993 53 (3) 523-527;

  
  
• Endocrinology

  Selective Increase in Type II Estrogen-binding Sites in the Dysplastic Dorsolateral Prostates of Noble Rats

  Shuk-mei Ho and Margaret Yu

  Cancer Res February 1 1993 53 (3) 528-532;

  
  
• Endocrinology

  Inhibition of Angiogenesis by Antiestrogens

  A. Gagliardi and D. C. Collins

  Cancer Res February 1 1993 53 (3) 533-535;

  
  
• Epidemiology

  Vegetables, Fruit, and Lung Cancer in the Iowa Women's Health Study

  Kristi A. Steinmetz, John D. Potter and Aaron R. Folsom

  Cancer Res February 1 1993 53 (3) 536-543;

  
  
• Experimental Therapeutics

  Reduced Glutathione Protects against Cisplatin-induced Neurotoxicity in Rats

  Frank P. T. Hamers, Jan H. Brakkee, Ennio Cavalletti, Michele Tedeschi, Laura Marmonti, Gabriella Pezzoni, Jan P. Neijt and Willem H. Gispen

  Cancer Res February 1 1993 53 (3) 544-549;

  
  
• Experimental Therapeutics

  Characterization of Experimental Mitoxantrone Cardiotoxicity and Its Partial Inhibition by ICRF-187 in Cultured Neonatal Rat Heart Cells

  N. G. Shipp, Robert T. Dorr, David S. Alberts, Brenda V. Dawson and Mary Hendrix

  Cancer Res February 1 1993 53 (3) 550-556;

  
  
• Experimental Therapeutics

  O-Phospho-l-tyrosine Inhibits Cellular Growth by Activating Protein Tyrosine Phosphatases

  Shrikant Mishra and Anne W. Hamburger

  Cancer Res February 1 1993 53 (3) 557-563;

  
  
• Experimental Therapeutics

  Nitric Oxide/Nucleophile Complexes Inhibit the in Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release

  Chris M. Maragos, Ji Ming Wang, Joseph A. Hrabie, Joost J. Oppenheim and Larry K. Keefer

  Cancer Res February 1 1993 53 (3) 564-568;

  
  
• Experimental Therapeutics

  Combined Interleukin 1β/Interleukin 2 Treatment in Mice: Synergistic Myelostimulatory Activity and Protection against Cyclophosphamide-induced Myelosuppression

  Enrico Proietti, Elena Tritarelli, Lucia Gabriele, Ugo Testa, Giampaolo Greco, Elvira Pelosi, Marco Gabbianelli, Filippo Belardelli and Cesare Peschle

  Cancer Res February 1 1993 53 (3) 569-576;

  
  
• Experimental Therapeutics

  Antisense DNA Inhibition of Tumor Growth Induced by c-Ha-ras Oncogene in Nude Mice

  Gary D. Gray, Olga M. Hernandez, Denise Hebel, Malcolm Root, Julio M. Pow-Sang and Eric Wickstrom

  Cancer Res February 1 1993 53 (3) 577-580;

  
  
• Experimental Therapeutics

  Antitumor Activity of N¹,N¹¹-Bis(ethyl)norspermine against Human Melanoma Xenografts and Possible Biochemical Correlates of Drug Action

  Carl W. Porter, Ralph J. Bernacki, John Miller and Raymond J. Bergeron

  Cancer Res February 1 1993 53 (3) 581-586;

  
  
• Experimental Therapeutics

  Markedly Improved Efficacy of Edatrexate Compared to Methotrexate in a High-Dose Regimen with Leucovorin Rescue against Metastatic Murine Solid Tumors

  F. M. Sirotnak, G. M. Otter and F. A. Schmid

  Cancer Res February 1 1993 53 (3) 587-591;

  
  
• Immunology

  Molecular Basis of Complement Resistance of Human Melanoma Cells Expressing the C3-cleaving Membrane Protease p65

  Markus W. Ollert, Joseph V. Kadlec, Eugene C. Petrella, Reinhard Bredehorst and Carl-Wilhelm Vogel

  Cancer Res February 1 1993 53 (3) 592-599;

  
  
• Immunology

  Improved Radioimmunotherapeutic Efficacy of an Anticarcinoma Monoclonal Antibody (¹³¹I-CC49) When Given in Combination with γ-Interferon

  John W. Greiner, Claudio Dansky Ullmann, Carol Nieroda, Chen-Feng Qi, Diane Eggensperger, Shinya Shimada, Seth M. Steinberg and Jeffrey Schlom

  Cancer Res February 1 1993 53 (3) 600-608;

  
  
• Molecular Biology and Genetics

  Hypersensitivity of Human Lymphocytes to UV-B and Solar Irradiation

  Colin F. Arlett, Jillian E. Lowe, Susan A. Harcourt, Alastair P. W. Waugh, Jane Cole, Leendert Roza, Brian L. Diffey, Toshio Mori, Osamu Nikaido and Michael H. L. Green

  Cancer Res February 1 1993 53 (3) 609-614;

  
  
• Molecular Biology and Genetics

  Tumor Necrosis Factor α and Interleukin 1α Induce Anchorage Independence in v-jun Transgenic Murine Cells

  Luc Vanhamme, Glenn M. Marshall, Andre C. Schuh, Martin L. Breitman and Peter K. Vogt

  Cancer Res February 1 1993 53 (3) 615-621;

  
  
• Molecular Biology and Genetics

  Characterization of Sarcoma Cell Lines from v-jun Transgenic Mice

  Glenn M. Marshall and Luc Vanhamme

  Cancer Res February 1 1993 53 (3) 622-626;

  
  
• Tumor Biology

  Differential Isolation of Normal Luminal Mammary Epithelial Cells and Breast Cancer Cells from Primary and Metastatic Sites Using Selective Media

  Stephen P. Ethier, Michael L. Mahacek, William J. Gullick, Thomas S. Frank and Barbara L. Weber

  Cancer Res February 1 1993 53 (3) 627-635;

  
  
• Tumor Biology

  Growth Inhibition of a Human Colorectal Carcinoma Cell Line by Interleukin 1 Is Associated with Enhanced Expression of γ-Interferon Receptors

  Arthur B. Raitano and Murray Korc

  Cancer Res February 1 1993 53 (3) 636-640;

  
  
• Tumor Biology

  Heterogeneity of Mucin Gene Expression in Normal and Neoplastic Tissues

  Samuel B. Ho, Gloria A. Niehans, Carolyn Lyftogt, Pei Sha Yan, David L. Cherwitz, Elizabeth T. Gum, Rajvir Dahiya and Young S. Kim

  Cancer Res February 1 1993 53 (3) 641-651;

  
  
• Tumor Biology

  Suramin Inhibits Growth and Yet Promotes Insulin-like Growth Factor II Expression in HepG2 Cells

  Andrea Kraft, Lola M. Reid and Isabel Zvibel

  Cancer Res February 1 1993 53 (3) 652-657;

  
  
• Tumor Biology

  Distribution of Colon Cancer Cells Permanently Labeled by Lectin-mediated Endocytosis of a Trap Label

  Christian Rushfeldt and Bård Smedsrød

  Cancer Res February 1 1993 53 (3) 658-662;

  
  
• Tumor Biology

  Morphological and Functional Properties of TM Preneoplastic Mammary Outgrowths

  Daniel Medina, Frances S. Kittrell, Yong-Jian Liu and Marlene Schwartz

  Cancer Res February 1 1993 53 (3) 663-667;

  
  
• Tumor Biology

  Growth Factor Dependency and Gene Expression in Preneoplastic Mouse Mammary Epithelial Cells

  Daniel Medina, Frances S. Kittrell, Carol J. Oborn and Marlene Schwartz

  Cancer Res February 1 1993 53 (3) 668-674;

  
  
• Tumor Biology

  Functional Expression of Interleukin 2 Receptor in a Human Factor-dependent Megakaryoblastic Leukemia Cell Line: Evidence That Granulocyte-Macrophage Colony-stimulating Factor Inhibits Interleukin 2 Binding to Its Receptor

  Yuzuru Kanakura, Hiroyuki Sugahara, Hideki Mitsui, Hirokazu Ikeda, Takuma Furitsu, Hirosuke Yagura, Hitoshi Kitayama, Yoshio Kanayama and Yuji Matsuzawa

  Cancer Res February 1 1993 53 (3) 675-680;

  
  
• Tumor Biology

  Chromosomes 8, 12, and 17 Copy Number in Astler-Coller Stage C Colon Cancer in Relation to Proliferative Activity and DNA Ploidy

  Melissa G. Steiner, Seth P. Harlow, Edoardo Colombo and Kenneth D. Bauer

  Cancer Res February 1 1993 53 (3) 681-686;

  
  
• Tumor Biology

  Milky Spots as the Implantation Site for Malignant Cells in Peritoneal Dissemination in Mice

  Akeo Hagiwara, Toshio Takahashi, Kiyoshi Sawai, Hiroki Taniguchi, Masataka Shimotsuma, Shinji Okano, Chouhei Sakakura, Hiroyuki Tsujimoto, Kimihiko Osaki, Sadayuki Sasaki and Morio Shirasu

  Cancer Res February 1 1993 53 (3) 687-692;

  
  
• Tumor Biology

  Melanoma-mediated Dissolution of Extracellular Matrix: Contribution of Urokinase-dependent and Metalloproteinase-dependent Proteolytic Pathways

  Anthony M. P. Montgomery, Yves A. De Clerck, Keith E. Langley, Ralph A. Reisfeld and Barbara M. Mueller

  Cancer Res February 1 1993 53 (3) 693-700;

  
  
• Tumor Biology

  Adhesion of Metastatic, ras-transformed NIH 3T3 Cells to Osteopontin, Fibronectin, and Laminin

  Ann F. Chambers, Charulata Hota and Charles W. Prince

  Cancer Res February 1 1993 53 (3) 701-706;

  
  
• Articles

  Announcements

  Cancer Res February 1 1993 53 (3) 707-709;