Table of Contents

Articles

• Advances in Brief

  Overexpression of a M_r 110,000 Vesicular Protein in Non-P-Glycoprotein-mediated Multidrug Resistance

  Rik J. Scheper, Henricus J. Broxterman, George L. Scheffer, Patricia Kaaijk, William S. Dalton, Theodorus H. M. van Heijningen, Coen K. van Kalken, Marilyn L. Slovak, Elisabeth G. E. de Vries, Paul van der Valk, Chris J. L. M. Meijer and Herbert M. Pinedo

  Cancer Res April 1 1993 53 (7) 1475-1479;

  
  
• Advances in Brief

  Expression of Sulfated Glycoprotein 2 Is Associated with Carcinogenesis Induced by N-Nitroso-N-methylurea in Rat Prostate and Seminal Vesicle

  Kenji Kadomatsu, Mario A. Anzano, Michael V. Slayter, Thomas S. Winokur, Joseph M. Smith and Michael B. Sporn

  Cancer Res April 1 1993 53 (7) 1480-1483;

  
  
• Advances in Brief

  Antibody-targeted Delivery of Doxorubicin Entrapped in Sterically Stabilized Liposomes Can Eradicate Lung Cancer in Mice

  Imran Ahmad, Michael Longenecker, John Samuel and Theresa M. Allen

  Cancer Res April 1 1993 53 (7) 1484-1488;

  
  
• Advances in Brief

  Mutation of K-ras Protooncogene in Human Ovarian Epithelial Tumors of Borderline Malignancy

  Samuel Chi-Ho Mok, Debra A. Bell, Robert C. Knapp, Paula M. Fishbaugh, William R. Welch, Michael G. Muto, Ross S. Berkowitz and Sai-Wah Tsao

  Cancer Res April 1 1993 53 (7) 1489-1492;

  
  
• Advances in Brief

  Cyclin E and Cyclin A as Canadidates for the Restriction Point Protein

  Qing-Ping Dou, Andrew H. Levin, Shanchuan Zhao and Arthur B. Pardee

  Cancer Res April 1 1993 53 (7) 1493-1497;

  
  
• Advances in Brief

  A Homozygous Deletion within the Carbonic Anhydrase-like Domain of the Ptprg Gene in Murine L-Cells

  Kishore K. Wary, Zhuangwei Lou, Arthur M. Buchberg, Linda D. Siracusa, Teresa Druck, Sal LaForgia and Kay Huebner

  Cancer Res April 1 1993 53 (7) 1498-1502;

  
  
• Perspectives in Cancer Research

  Signaling by Integrins: Implications for Tumorigenesis

  Martin Alexander Schwartz

  Cancer Res April 1 1993 53 (7) 1503-1506;

  
  
• Biochemistry and Biophysics

  Caffeine Release of Radiation Induced S and G₂ Phase Arrest in V79 Hamster Cells: Increase of Histone Messenger RNA Levels and p34^cdc2 Activation

  Jens Hain, Nigel E. A. Crompton, Werner Burkart and Rolf Jaussi

  Cancer Res April 1 1993 53 (7) 1507-1510;

  
  
• Carcinogenesis

  Presence of Point Mutations in the N-ras Gene in Radiation-transformed Rat Embryo Cells

  Chang Hu Chen, Brian Endlich, Reza Salavati and C. Clifton Ling

  Cancer Res April 1 1993 53 (7) 1511-1515;

  
  
• Carcinogenesis

  A Link between ras and Metastatic Behavior of Tumor Cells: ras Induces CD44 Promoter Activity and Leads to Low-Level Expression of Metastasis-specific Variants of CD44 in CREF Cells

  Martin Hofmann, Wolfgang Rudy, Ursula Günthert, Stephen G. Zimmer, Volker Zawadzki, Margot Zöller, Rosemarie B. Lichtner, Peter Herrlich and Helmut Ponta

  Cancer Res April 1 1993 53 (7) 1516-1521;

  
  
• Carcinogenesis

  Detection of DNA Adducts in Human Oral Tissue: Correlation of Adduct Levels with Tobacco Smoking and Differential Enhancement of Adducts Using the Butanol Extraction and Nuclease P1 Versions of ³²P Postlabeling

  Nigel J. Jones, Alan D. McGregor and Raymond Waters

  Cancer Res April 1 1993 53 (7) 1522-1528;

  
  
• Carcinogenesis

  Glucuronidation of Carcinogen Metabolites by Complementary DNA-expressed Uridine 5′-Diphosphate Glucuronosyltransferases

  Peter I. Mackenzie, Louise Rodbourn and Takashi Iyanagi

  Cancer Res April 1 1993 53 (7) 1529-1533;

  
  
• Clinical Investigations

  Chronopharmacology of High-Dose Busulfan in Children

  Gilles Vassal, Dominique Challine, Serge Koscielny, Olivier Hartmann, Alain Deroussent, Isabelle Boland, Dominique Valteau-Couanet, Jean Lemerle, Francis Lévi and Alain Gouyette

  Cancer Res April 1 1993 53 (7) 1534-1537;

  
  
• Endocrinology

  Interleukin-1α and Interleukin-6 Act Additively to Inhibit Growth of MCF-7 Breast Cancer Cells in Vitro

  David N. Danforth Jr. and Magdalene K. Sgagias

  Cancer Res April 1 1993 53 (7) 1538-1545;

  
  
• Endocrinology

  Pituitary Tumors in Mice Exposed Prenatally to Diethylstilbestrol

  Bruce E. Walker and Lori A. Kurth

  Cancer Res April 1 1993 53 (7) 1546-1549;

  
  
• Experimental Therapeutics

  Pharmacokinetic and Pharmacodynamic Advantages of Pirarubicin over Adriamycin after Intraarterial Hepatic Administration in the Rabbit VX2 Tumor Model

  Jean-Nicolas Munck, Marcello Riggi, Philippe Rougier, Guy G. Chabot, Luis H. Ramirez, Zhongxin Zhao, Caroline Bognel, Patrice Ardouin, Patrice Herait and Alain Gouyette

  Cancer Res April 1 1993 53 (7) 1550-1554;

  
  
• Experimental Therapeutics

  Inhibition of Multidrug Resistance by a New Staurosporine Derivative, NA-382, in Vitro and in Vivo

  Ken-ichi Miyamoto, Kosei Inoko, Shinya Wakusawa, Shinji Kajita, Takaaki Hasegawa, Kenzo Takagi and Masao Koyama

  Cancer Res April 1 1993 53 (7) 1555-1559;

  
  
• Experimental Therapeutics

  Antitumor Activity of the Weekly Intravenous Push Schedule of 5-Fluoro-2′-deoxyuridine ± N-Phosphonacetyl-l-aspartate in Mice Bearing Advanced Colon Carcinoma 26

  J. A. M. van Laar, F. A. Durrani and Y. M. Rustum

  Cancer Res April 1 1993 53 (7) 1560-1564;

  
  
• Experimental Therapeutics

  Protective Effects of Recombinant Human Interleukin-1α in Doxorubicin-treated Normal and Tumor-bearing Mice

  David H. Lynch, Abbe S. Rubin, Robert E. Miller and Douglas E. Williams

  Cancer Res April 1 1993 53 (7) 1565-1570;

  
  
• Experimental Therapeutics

  Tamoxifen Modulation of Cisplatin Sensitivity in Human Malignant Melanoma Cells

  Edward F. Mc Clay, Kathleen D. Albright, Jeffrey A. Jones, Randolph D. Christen and Stephen B. Howell

  Cancer Res April 1 1993 53 (7) 1571-1576;

  
  
• Experimental Therapeutics

  Regression of Human Breast Carcinoma Tumors in Immunodeficient Mice Treated with 9-Nitrocamptothecin: Differential Response of Nontumorigenic and Tumorigenic Human Breast Cells in Vitro

  Panayotis Pantazis, Janet A. Early, Anthony J. Kozielski, John T. Mendoza, Hellmuth R. Hinz and Beppino C. Giovanella

  Cancer Res April 1 1993 53 (7) 1577-1582;

  
  
• Experimental Therapeutics

  In Vitro Cytotoxicity, Cellular Pharmacology, and DNA Lesions Induced by Annamycin, an Anthracycline Derivative with High Affinity for Lipid Membranes

  Yi-He Ling, Waldemar Priebe, Li-Ying Yang, Thomas G. Burke, Yves Pommier and Roman Perez-Soler

  Cancer Res April 1 1993 53 (7) 1583-1589;

  
  
• Experimental Therapeutics

  High-Energy Shock Waves Induce Blood Flow Reduction in Tumors

  Fernando Gamarra, Fritz Spelsberg, Gerhard E. H. Kuhnle and Alwin E. Goetz

  Cancer Res April 1 1993 53 (7) 1590-1595;

  
  
• Experimental Therapeutics

  Prolongation of Drug Exposure in Cerebrospinal Fluid by Encapsulation into DepoFoam

  Sinil Kim, Shirin Khatibi, Stephen B. Howell, Cindy McCully, Frank M. Balis and David G. Poplack

  Cancer Res April 1 1993 53 (7) 1596-1598;

  
  
• Experimental Therapeutics

  Increase in Thermosensitivity of Tumor Cells by Lowering Intracellular pH

  Chang W. Song, John C. Lyons, Robert J. Griffin, Carol M. Makepeace and Edward J. Cragoe Jr.

  Cancer Res April 1 1993 53 (7) 1599-1601;

  
  
• Immunology

  Properties of a M_r 110,000 Tumor Rejection Antigen of the Chemically Induced BALB/c Meth A Sarcoma

  Albert B. De Leo, Matthew Becker, Lina Lu and Lloyd W. Law

  Cancer Res April 1 1993 53 (7) 1602-1607;

  
  
• Immunology

  Intestinal Intraepithelial Lymphocytes Bind to Colon Cancer Cells by HML-1 and CD11a

  Arthur I. Roberts, Sean M. O'Connell and Ellen C. Ebert

  Cancer Res April 1 1993 53 (7) 1608-1611;

  
  
• Immunology

  Differential Regulation of Carcinoembryonic Antigen and Biliary Glycoprotein by γ-Interferon

  Hiroki Takahashi, Yasuji Okai, Raymond J. Paxton, Laura J. F. Hefta and John E. Shively

  Cancer Res April 1 1993 53 (7) 1612-1619;

  
  
• Molecular Biology and Genetics

  ras Mutations in 2-Acetylaminofluorene-induced Lung and Liver Tumors from C3H/HeJ and (C3H×A/J)F1 Mice

  Yue Wang, Yian Wang, Gary Stoner and Ming You

  Cancer Res April 1 1993 53 (7) 1620-1624;

  
  
• Molecular Biology and Genetics

  High Mutation Frequency in ras Genes of Skin Tumors Isolated from DNA Repair Deficient Xeroderma Pigmentosum Patients

  Leela Daya-Grosjean, Caroline Robert, Christiane Drougard, Horacio Suarez and Alain Sarasin

  Cancer Res April 1 1993 53 (7) 1625-1629;

  
  
• Molecular Biology and Genetics

  Transforming Growth Factor-α Production and Autoinduction in a Colorectal Carcinoma Cell Line (DiFi) with an Amplified Epidermal Growth Factor Receptor Gene

  Seema Untawale, Mark A. Zorbas, Clague P. Hodgson, Robert J. Coffey, Gary E. Gallick, Susan M. North, David M. Wildrick, Matilde Olive, Mark Blick, Lynn C. Yeoman and Bruce M. Boman

  Cancer Res April 1 1993 53 (7) 1630-1636;

  
  
• Molecular Biology and Genetics

  Somatic p53 Mutations in Human Breast Carcinomas in an Icelandic Population: A Prognostic Factor

  Steinunn Thorlacius, Anne-Lise Börresen and Jorunn E. Eyfjörd

  Cancer Res April 1 1993 53 (7) 1637-1641;

  
  
• Molecular Biology and Genetics

  Ultraviolet-induced Cyclobutane Pyrimidine Dimers Are Selectively Removed from Transcriptionally Active Genes in the Epidermis of the Hairless Mouse

  Hendrik J. T. Ruven, Rob J. W. Berg, C. Maud J. Seelen, Joël A. J. M. Dekkers, Paul H. M. Lohman, Leon H. F. Mullenders and Albert A. van Zeeland

  Cancer Res April 1 1993 53 (7) 1642-1645;

  
  
• Molecular Biology and Genetics

  p53 Mutations Selected in Vivo When Mouse Mammary Epithelial Cells Form Hyperplastic Outgrowths Are Not Necessary for Establishment of Mammary Cell Lines in Vitro

  Michelle A. Ozbun, D. Joseph Jerry, Frances S. Kittrell, Daniel Medina and Janet S. Butel

  Cancer Res April 1 1993 53 (7) 1646-1652;

  
  
• Molecular Biology and Genetics

  Splicing Mutations of the p53 Gene in Human Hepatocellular Carcinoma

  Ming-Yang Lai, Hua-Chen Chang, Hsin-Pai Li, Chen-Kuo Ku, Pei-Jer Chen, Jin-Chuan Sheu, Guan-Tarng Huang, Po-Huang Lee and Ding-Shinn Chen

  Cancer Res April 1 1993 53 (7) 1653-1656;

  
  
• Molecular Biology and Genetics

  Transcriptional Activation of the Mouse mdr3 Gene Coincides with the Appearance of Novel Transcription Initiation Sites in Multidrug-resistant P388 Tumor Cells

  Pierre Lepage, Martine Raymond, Alain Nepveu and Philippe Gros

  Cancer Res April 1 1993 53 (7) 1657-1664;

  
  
• Molecular Biology and Genetics

  Multiple Mechanisms of Tumorigenesis in Eµ-myc Transgenic Mice

  Charles L. Sidman, Terese M. Denial, Jan D. Marshall and John B. Roths

  Cancer Res April 1 1993 53 (7) 1665-1669;

  
  
• Molecular Biology and Genetics

  Chromosome 12 Breakpoints Are Cytogenetically Different in Benign and Malignant Lipogenic Tumors: Localization of Breakpoints in Lipoma to 12q15 and in Myxoid Liposarcoma to 12q13.3

  Krzysztof Mrózek, Constantine P. Karakousis and Clara D. Bloomfield

  Cancer Res April 1 1993 53 (7) 1670-1675;

  
  
• Molecular Biology and Genetics

  Discordant p53 Gene Mutations in Primary Head and Neck Cancers and Corresponding Second Primary Cancers of the Upper Aerodigestive Tract

  Kyung Y. Chung, Tapas Mukhopadhyay, Jhingook Kim, Alan Casson, Jae Y. Ro, Helmuth Goepfert, Waun K. Hong and Jack A. Roth

  Cancer Res April 1 1993 53 (7) 1676-1683;

  
  
• Molecular Biology and Genetics

  Altered Chromosomal Methylation Patterns Accompany Oncogene-induced Transformation of Human Bronchial Epithelial Cells

  Paula M. Vertino, Elisa A. Spillare, Curtis C. Harris and Stephen B. Baylin

  Cancer Res April 1 1993 53 (7) 1684-1689;

  
  
• Tumor Biology

  E-Cadherin Expression in Primary and Metastatic Gastric Cancer: Down-Regulation Correlates with Cellular Dedifferentiation and Glandular Disintegration

  Barbara Mayer, Judith P. Johnson, Florian Leitl, Karl W. Jauch, Markus M. Heiss, Friedrich W. Schildberg, Walter Birchmeier and Ilona Funke

  Cancer Res April 1 1993 53 (7) 1690-1695;

  
  
• Tumor Biology

  Expression of E-Cadherin Cell Adhesion Molecules in Human Breast Cancer Tissues and Its Relationship to Metastasis

  Hiroshi Oka, Hitoshi Shiozaki, Kenji Kobayashi, Masatoshi Inoue, Hideaki Tahara, Tetsurou Kobayashi, Yuuichi Takatsuka, Norihisa Matsuyoshi, Shinji Hirano, Masatoshi Takeichi and Takesada Mori

  Cancer Res April 1 1993 53 (7) 1696-1701;

  
  
• Tumor Biology

  Protein Interaction of Retinoblastoma Gene Product pRb110 with M_r 73,000 Heat Shock Cognate Protein

  Takehito Nihei, Shuji Takahashi, Satoru Sagae, Noriyuki Sato and Kokichi Kikuchi

  Cancer Res April 1 1993 53 (7) 1702-1705;

  
  
• Tumor Biology

  Expression of Sialyl-Tn Antigens in Normal Squamous Epithelium, Dysplasia, and Squamous Cell Carcinoma in the Esophagus

  Yoichi Ikeda, Hiroyuki Kuwano, Kinya Baba, Masahiko Ikebe, Tetuya Matushima, Yousuke Adachi, Masaki Mori and Keizo Sugimachi

  Cancer Res April 1 1993 53 (7) 1706-1708;

  
  
• Tumor Biology

  Recombinant Human Stem Cell Factor Mediates Chemotaxis of Small-Cell Lung Cancer Cell Lines Aberrantly Expressing the c-kit Protooncogene

  Yoshitaka Sekido, Takashi Takahashi, Ryuzo Ueda, Masahide Takahashi, Hiroko Suzuki, Keiko Nishida, Tetsuya Tsukamoto, Toyoaki Hida, Kaoru Shimokata, Krisztina M. Zsebo and Toshitada Takahashi

  Cancer Res April 1 1993 53 (7) 1709-1714;

  
  
• Articles

  Announcements

  Cancer Res April 1 1993 53 (7) 1715-1716;

  
  
• Articles

  Recent Death

  Cancer Res April 1 1993 53 (7) 1716-1716;

  
  
• Articles

  Calendar of Events

  Cancer Res April 1 1993 53 (7) 1717-1717;