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Advances in Brief

Heterogeneity of Subcellular Localization of p53 Protein in Human Glioblastomas

Iqbal Unnisa Ali, John B. Schweitzer, Barbara Ikejiri, Abha Saxena, James T. Robertson and Edward H. Oldfield
Iqbal Unnisa Ali
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John B. Schweitzer
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Barbara Ikejiri
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Abha Saxena
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James T. Robertson
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Edward H. Oldfield
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DOI:  Published January 1994
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Abstract

Immunohistochemical analysis of the p53 protein in human glioblastomas with known genetic profiles of p53 mutations and allele losses on chromosome 17p demonstrated a heterogeneous pattern of subcellular compartmentalization of the p53 protein. Tumors with a single wild type copy of the p53 gene but with allelic deletions on chromosome 17p exhibit nuclear and/or cytoplasmic accumulation of p53, whereas tumors with both copies of the wild type gene and no allele losses on chromosome 17 do not accumulate p53. Glioblastomas with one normal and one mutated copy of the p53 gene and allelic deletions on 17p distal to p53, on the other hand, show predominantly cytoplasmic staining, probably originating from the wild type p53 protein. Furthermore, tumors with mutations in the same codon of p53 display quite different intracellular distribution suggesting that, in addition to the genotype of p53, the intracellular microenvironment of a particular tumor is important in determining the subcellular localization of the p53 protein.

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • Received September 20, 1993.
  • Accepted November 12, 1993.
  • ©1994 American Association for Cancer Research.
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January 1994
Volume 54, Issue 1
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Heterogeneity of Subcellular Localization of p53 Protein in Human Glioblastomas
Iqbal Unnisa Ali, John B. Schweitzer, Barbara Ikejiri, Abha Saxena, James T. Robertson and Edward H. Oldfield
Cancer Res January 1 1994 (54) (1) 1-5;

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Heterogeneity of Subcellular Localization of p53 Protein in Human Glioblastomas
Iqbal Unnisa Ali, John B. Schweitzer, Barbara Ikejiri, Abha Saxena, James T. Robertson and Edward H. Oldfield
Cancer Res January 1 1994 (54) (1) 1-5;
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