Table of Contents

Articles

• Advances in Brief

  Both the Cytosols and Detergent Extracts of Breast Cancer Tissues Are Suited to Evaluate the Prognostic Impact of the Urokinase-Type Plasminogen Activator and Its Inhibitor, Plasminogen Activator Inhibitor Type 1

  Fritz Jänicke, Lothar Pache, Manfred Schmitt, Kurt Ulm, Christoph Thomssen, Anita Prechtl and Henner Graeff

  Cancer Res May 15 1994 54 (10) 2527-2530;

  
  
• Advances in Brief

  Interleukin-2-secreting Mouse Fibroblasts Transfected with Genomic DNA from Murine Melanoma Cells Prolong the Survival of Mice with Melanoma

  Tae Sung Kim and Edward P. Cohen

  Cancer Res May 15 1994 54 (10) 2531-2535;

  
  
• Advances in Brief

  Phosphoinositide Signaling in Nuclei of Friend Cells: Phospholipase C β Down-Regulation Is Related to Cell Differentiation

  Alberto M. Martelli, Anna M. Billi, R. Stewart Gilmour, Luca M. Neri, Lucia Manzoli, Andrea Ognibene and Lucio Cocco

  Cancer Res May 15 1994 54 (10) 2536-2540;

  
  
• Advances in Brief

  Elongation Factor 1δ Is Enhanced following Exposure to Ionizing Radiation

  Mira Jung, Alexei D. Kondratyev and Anatoly Dritschilo

  Cancer Res May 15 1994 54 (10) 2541-2543;

  
  
• Advances in Brief

  Radiosensitivity of Ataxia-Telangiectasia, X-Linked Agammaglobulinemia, and Related Syndromes Using a Modified Colony Survival Assay

  Young K. Huo, Zhijun Wang, Ji-Hong Hong, Luciana Chessa, William H. McBride, Susan L. Perlman and Richard A. Gatti

  Cancer Res May 15 1994 54 (10) 2544-2547;

  
  
• Advances in Brief

  Evidence for Involvement of BRCA1 in Sporadic Breast Carcinomas

  Craig S. Cropp, Heli A. Nevanlinna, Seppo Pyrhönen, Ulf-Håkan Stenman, Paul Salmikangas, Hans Albertsen, Ray White and Robert Callahan

  Cancer Res May 15 1994 54 (10) 2548-2551;

  
  
• Advances in Brief

  Methylation of the Estrogen Receptor Gene CpG Island Marks Loss of Estrogen Receptor Expression in Human Breast Cancer Cells

  Yvonne L. Ottaviano, Jean-Pierre Issa, Fritz F. Parl, Helene S. Smith, Stephen B. Baylin and Nancy E. Davidson

  Cancer Res May 15 1994 54 (10) 2552-2555;

  
  
• Advances in Brief

  Cross-Resistance to Cisplatin in Cells Resistant to Photofrin-mediated Photodynamic Therapy

  Roger A. Moorehead, Steven G. Armstrong, Brian C. Wilson and Gurmit Singh

  Cancer Res May 15 1994 54 (10) 2556-2559;

  
  
• Advances in Brief

  Developmental Regulation of Genomic Imprinting of the IGF2 Gene in Human Liver

  Stella M. Davies

  Cancer Res May 15 1994 54 (10) 2560-2562;

  
  
• Advances in Brief

  Cellular Interactions of CRKL, an SH2–SH3 Adaptor Protein

  Johanna ten Hoeve, Vesa Kaartinen, Thoas Fioretos, Leena Haataja, Jan-Willem Voncken, Nora Heisterkamp and John Groffen

  Cancer Res May 15 1994 54 (10) 2563-2567;

  
  
• Advances in Brief

  Suppression of Tumorigenicity in Human Teratocarcinoma Cell Line PA-1 by Introduction of Chromosome 4

  I. Jean McGowan-Jordan, Marsha D. Speevak, David Blakey and Mario Chevrette

  Cancer Res May 15 1994 54 (10) 2568-2572;

  
  
• Advances in Brief

  Positron Emission Tomography Analysis of Metastatic Tumor Cell Trafficking

  Naoto Oku, Chieko Koike, Masaaki Sugawara, Hideo Tsukada, Tatsuro Irimura and Shoji Okada

  Cancer Res May 15 1994 54 (10) 2573-2576;

  
  
• Advances in Brief

  Androgen-independent Cancer Progression and Bone Metastasis in the LNCaP Model of Human Prostate Cancer

  George N. Thalmann, Ploutarchos E. Anezinis, Shi-Ming Chang, Haiyen E. Zhau, E. Edmund Kim, Vicki L. Hopwood, Sen Pathak, Andrew C. von Eschenbach and Leland W. K. Chung

  Cancer Res May 15 1994 54 (10) 2577-2581;

  
  
• Biochemistry and Biophysics

  Basic Fibroblast Growth Factor Protects Endothelial Cells against Radiation-induced Programmed Cell Death in Vitro and in Vivo

  Zvi Fuks, Roger S. Persaud, Alan Alfieri, Maureen McLoughlin, Desiree Ehleiter, Jeffery L. Schwartz, Andrew P. Seddon, Carlos Cordon-Cardo and Adriana Haimovitz-Friedman

  Cancer Res May 15 1994 54 (10) 2582-2590;

  
  
• Biochemistry and Biophysics

  Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells against Radiation-induced Apoptosis

  Adriana Haimovitz-Friedman, Naomi Balaban, Maureen McLoughlin, Desiree Ehleiter, Joseph Michaeli, Israel Vlodavsky and Zvi Fuks

  Cancer Res May 15 1994 54 (10) 2591-2597;

  
  
• Biochemistry and Biophysics

  Characterization of Tumor-associated Neural Cell Adhesion Molecule in Human Serum

  Kiyoshi Takamatsu, Bernhard Auerbach, Rita Gerardy-Schahn, Matthias Eckhardt, Gabriele Jaques and Norbert Madry

  Cancer Res May 15 1994 54 (10) 2598-2603;

  
  
• Biochemistry and Biophysics

  Homologous and Heterologous Regulation of α-Melanocyte-stimulating Hormone Receptors in Human and Mouse Melanoma Cell Lines

  Walter Siegrist, Sibylla Stutz and Alex N. Eberle

  Cancer Res May 15 1994 54 (10) 2604-2610;

  
  
• Biochemistry and Biophysics

  1-Phosphatidylinositol 4-Kinase: An Enzyme Linked with Proliferation and Malignancy

  Maria Teresa Rizzo and George Weber

  Cancer Res May 15 1994 54 (10) 2611-2614;

  
  
• Carcinogenesis

  Differential Expression of Human Wnt Genes 2, 3, 4, and 7B in Human Breast Cell Lines and Normal and Disease States of Human Breast Tissue

  Emmanuel L. Huguet, Jill A. McMahon, Andrew P. McMahon, Roy Bicknell and Adrian L. Harris

  Cancer Res May 15 1994 54 (10) 2615-2621;

  
  
• Carcinogenesis

  Inhibition of Cell Proliferation by Ciprofibrate in Glutathione S-Transferase P1-1-positive Rat Hepatic Hyperplastic Nodules

  Zhi-Ying Chen, Ying-Fei Liu, Cheng-Yi He, Collin C. White and David L. Eaton

  Cancer Res May 15 1994 54 (10) 2622-2629;

  
  
• Carcinogenesis

  Persistence of Carcinogen-altered Cell Population in Rat Urothelium Which Can Be Promoted to Tumors by Chronic Inflammatory Stimulus

  Koji Kawai, Hitoshi Kawamata, Shuji Kemeyama, Alfred Rademaker and Ryoichi Oyasu

  Cancer Res May 15 1994 54 (10) 2630-2632;

  
  
• Carcinogenesis

  Allelic Loss at the Predisposing Gene Locus in Spontaneous and Chemically Induced Renal Cell Carcinomas in the Eker Rat

  Yoshiaki Kubo, Hiroaki Mitani and Okio Hino

  Cancer Res May 15 1994 54 (10) 2633-2635;

  
  
• Clinical Investigations

  Phase I Clinical Trial of Irinotecan (CPT-11), 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, and Cisplatin in Combination with Fixed Dose of Vindesine in Advanced Non-Small Cell Lung Cancer

  Tetsu Shinkai, Hitoshi Arioka, Hiroshi Kunikane, Kenji Eguchi, Yasutsuna Sasaki, Tomohide Tamura, Yuichiro Ohe, Fumihiro Oshita, Makoto Nishio, Atsuya Karato, Hiroaki Okamoto, Hajime Nakashima, Hironobu Ohmatsu, Junichi Shiraishi, Naohiro Nomura and Nagahiro Saijo

  Cancer Res May 15 1994 54 (10) 2636-2642;

  
  
• Experimental Therapeutics

  Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice

  Silvio Folli, Patrick Westermann, Daniel Braichotte, André Pèlegrin, Georges Wagnières, Hubert van den Bergh and Jean-Pierre Mach

  Cancer Res May 15 1994 54 (10) 2643-2649;

  
  
• Experimental Therapeutics

  Effects of Sonicated Eosinophils on the in Vitro Sensitivity of Human Lymphoma Cells to Glucose Oxidase

  Michael K. Samoszuk, Vincent Nguyen, Cherry T. Thomas and Dawn M. Jacobson

  Cancer Res May 15 1994 54 (10) 2650-2653;

  
  
• Experimental Therapeutics

  Suramin, an Anticancer and Angiosuppressive Agent, Inhibits Endothelial Cell Binding of Basic Fibroblast Growth Factor, Migration, Proliferation, and Induction of Urokinase-Type Plasminogen Activator

  Shingo Takano, Stephen Gately, Mary E. Neville, William F. Herblin, Janet L. Gross, Herbert Engelhard, Michael Perricone, Kristi Eidsvoog and Steven Brem

  Cancer Res May 15 1994 54 (10) 2654-2660;

  
  
• Experimental Therapeutics

  Selective in Vivo Accumulation of N-Acetyl-4-S-cysteaminylphenol in B16F10 Murine Melanoma and Enhancement of Its in Vitro and in Vivo Antimelanoma Effect by Combination of Buthionine Sulfoximine

  Frank Alena, Takashi Iwashina, Adrian Gili and Kowichi Jimbow

  Cancer Res May 15 1994 54 (10) 2661-2666;

  
  
• Experimental Therapeutics

  Interleukin-1 Receptor Blockade Reduces the Number and Size of Murine B16 Melanoma Hepatic Metastases

  Fernando Vidal-Vanaclocha, Cristian Amézaga, Aintzane Asumendi, Gilles Kaplanski and Charles A. Dinarello

  Cancer Res May 15 1994 54 (10) 2667-2672;

  
  
• Experimental Therapeutics

  Novel 6,5-fused Ring Heterocyclic Antifolates: Biochemical and Biological Characterization

  John J. McGuire, Vladimir V. Bergoltz, Kathryn J. Heitzman, William H. Haile, Cynthia A. Russell, Wanda E. Bolanowska, Yoshihiko Kotake, Toru Haneda and Hiroaki Nomura

  Cancer Res May 15 1994 54 (10) 2673-2679;

  
  
• Experimental Therapeutics

  Cellular Pharmacology of Dichloro(ethylenediamine)platinum(II) in Cisplatin-sensitive and Resistant Human Ovarian Carcinoma Cells

  Antti P. Jekunen, Doreen K. Hom, John E. Alcaraz, Alan Eastman and Stephen B. Howell

  Cancer Res May 15 1994 54 (10) 2680-2687;

  
  
• Experimental Therapeutics

  Establishment of New SCID and Nude Mouse Models of Human B Leukemia/Lymphoma and Effective Therapy of the Tumors with Immunotoxin and Monoclonal Antibody: Marked Difference between the SCID and Nude Mouse Models in the Antitumor Efficacy of Monoclonal Antibody

  Akira Kawata, Minoru Yoshida, Morihiro Okazaki, Soichiro Yokota, Maurice Barcos and Ben K. Seon

  Cancer Res May 15 1994 54 (10) 2688-2694;

  
  
• Experimental Therapeutics

  An in Vivo Comparison of Oral 5-Iodo-2′-deoxyuridine and 5-Iodo-2-pyrimidinone-2′-deoxyribose Toxicity, Pharmacokinetics, and DNA Incorporation in Athymic Mouse Tissues and the Human Colon Cancer Xenograft, HCT-116

  Timothy J. Kinsella, Keith A. Kunugi, Kathleen A. Vielhuber, William McCulloch, Shwu-Huey Liu and Yung-Chi Cheng

  Cancer Res May 15 1994 54 (10) 2695-2700;

  
  
• Experimental Therapeutics

  Iododeoxyuridine Chemosensitization of cis-Diamminedichloroplatinum(II) in Human Bladder Cancer Cells

  Kwan-Hwa Chi, Keith A. Kunugi and Timothy J. Kinsella

  Cancer Res May 15 1994 54 (10) 2701-2706;

  
  
• Experimental Therapeutics

  Antiestrogenic Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on 17β-Estradiol-induced pS2 Expression

  Tim R. Zacharewski, Karen L. Bondy, Pamela McDonell and Zhi Fen Wu

  Cancer Res May 15 1994 54 (10) 2707-2713;

  
  
• Experimental Therapeutics

  Antitumor Activity and Pharmacokinetics in Mice of a Recombinant Immunotoxin Containing a Disulfide-stabilized Fv Fragment

  Yoram Reiter, Lee H. Pai, Ulrich Brinkmann, Qing-cheng Wang and Ira Pastan

  Cancer Res May 15 1994 54 (10) 2714-2718;

  
  
• Experimental Therapeutics

  Intratumoral Generation of 5-Fluorouracil Mediated by an Antibody-Cytosine Deaminase Conjugate in Combination with 5-Fluorocytosine

  Philip M. Wallace, John F. MacMaster, Virginia F. Smith, David E. Kerr, Peter D. Senter and Wesley L. Cosand

  Cancer Res May 15 1994 54 (10) 2719-2723;

  
  
• Experimental Therapeutics

  Depletion of the erbB-2 Gene Product p185 by Benzoquinoid Ansamycins

  Penny Miller, Catherine DiOrio, Mikel Moyer, Rodney C. Schnur, Arthur Bruskin, Walter Cullen and James D. Moyer

  Cancer Res May 15 1994 54 (10) 2724-2730;

  
  
• Immunology

  Cytotoxic T-Lymphocyte Response to Autologous Human Squamous Cell Cancer of the Lung: Epitope Reconstitution with Peptides Extracted from HLA-Aw68

  Craig L. Slingluff Jr., Andrea L. Cox, John M. Stover Jr., Marcia M. Moore, Donald F. Hunt and Victor H. Engelhard

  Cancer Res May 15 1994 54 (10) 2731-2737;

  
  
• Immunology

  Antitumor × Anti-CD3 Bifunctional Antibodies Redirect T-Cells Activated in Vivo with Staphylococcal Enterotoxin B to Neutralize Pulmonary Metastases

  Christophe Penna, Phillip A. Dean and Heidi Nelson

  Cancer Res May 15 1994 54 (10) 2738-2743;

  
  
• Immunology

  Characteristics and in Vivo Homing of Long-Term T-Cell Lines and Clones Derived from Tumor-draining Lymph Nodes

  Takafumi Matsumura, Jeffrey J. Sussman, Robert A. Krinock, Alfred E. Chang and Suyu Shu

  Cancer Res May 15 1994 54 (10) 2744-2750;

  
  
• Molecular Biology and Genetics

  Nickel-induced Transformation of Human Cells Causes Loss of the Phosphorylation of the Retinoblastoma Protein

  Xinhua Lin, W. Karol Dowjat and Max Costa

  Cancer Res May 15 1994 54 (10) 2751-2754;

  
  
• Molecular Biology and Genetics

  The p53-dependent γ-Ray Response of GADD45

  Qimin Zhan, Insoo Bae, Michael B. Kastan and Albert J. Fornace Jr.

  Cancer Res May 15 1994 54 (10) 2755-2760;

  
  
• Molecular Biology and Genetics

  Allelotype of Pancreatic Adenocarcinoma

  Albert B. Seymour, Ralph H. Hruban, Mark Redston, Carlos Caldas, Steve M. Powell, Kenneth W. Kinzler, Charles J. Yeo and Scott E. Kern

  Cancer Res May 15 1994 54 (10) 2761-2764;

  
  
• Molecular Biology and Genetics

  Genetic Identification of Mcs-1, a Rat Mammary Carcinoma Suppressor Gene

  Lih-Ching Hsu, Wendy S. Kennan, Laurie A. Shepel, Howard J. Jacob, Claude Szpirer, Josiane Szpirer, Eric S. Lander and Michael N. Gould

  Cancer Res May 15 1994 54 (10) 2765-2770;

  
  
• Tumor Biology

  Sensitivity of HER-2/neu Antibodies in Archival Tissue Samples: Potential Source of Error in Immunohistochemical Studies of Oncogene Expression

  Michael F. Press, Gene Hung, William Godolphin and Dennis J. Slamon

  Cancer Res May 15 1994 54 (10) 2771-2777;

  
  
• Tumor Biology

  Spontaneous Transformation of Rat Ovarian Surface Epithelial Cells Results in Well to Poorly Differentiated Tumors with a Parallel Range of Cytogenetic Complexity

  Joseph R. Testa, Lori A. Getts, Hernando Salazar, Zemin Liu, Laura M. Handel, Andrew K. Godwin and Thomas C. Hamilton

  Cancer Res May 15 1994 54 (10) 2778-2784;

  
  
• Tumor Biology

  Induction of Metastatic Ability in a Stably Diploid Benign Rat Mammary Epithelial Cell Line by Transfection with DNA from Human Malignant Breast Carcinoma Cell Lines

  Barry R. Davies, Roger Barraclough and Philip S. Rudland

  Cancer Res May 15 1994 54 (10) 2785-2793;

  
  
• Tumor Biology

  Fibroblast Growth Factor Receptor Gene Expression and Immunoreactivity Are Elevated in Human Glioblastoma Multiforme

  Richard S. Morrison, Fumio Yamaguchi, Janet M. Bruner, Mark Tang, Wallace McKeehan and Mitchel S. Berger

  Cancer Res May 15 1994 54 (10) 2794-2799;

  
  
• Tumor Biology

  Neovascularization in Clinical Stage A Testicular Germ Cell Tumor: Prediction of Metastatic Disease

  Dolores Olivarez, Thomas Ulbright, Werner DeRiese, Richard Foster, Terry Reister, Lawrence Einhorn and George Sledge

  Cancer Res May 15 1994 54 (10) 2800-2802;

  
  
• Tumor Biology

  Human Osteosarcoma Cell Lines Are Dependent on Insulin-like Growth Factor I for in Vitro Growth

  Cynthia Chavez Kappel, Maria C. Velez-Yanguas, Steven Hirschfeld and Lee J. Helman

  Cancer Res May 15 1994 54 (10) 2803-2807;

  
  
• Virology

  Ultrastructural Localization of BHRF1: An Epstein-Barr Virus Gene Product Which Has Homology with bcl-2

  Tamas Hickish, David Robertson, Paul Clarke, Mark Hill, Francesca di Stefano, Catherine Clarke and David Cunningham

  Cancer Res May 15 1994 54 (10) 2808-2811;

  
  
• Meeting Report

  Cell Death in Cancer and Development

  Alan Eastman, Steven Grant, Richard Lock, Thomas Tritton, Nancy Van Houten and Junying Yuan

  Cancer Res May 15 1994 54 (10) 2812-2818;

  
  
• Articles

  Announcements

  Cancer Res May 15 1994 54 (10) 2819-2821;

  
  
• Articles

  Erratum

  Cancer Res May 15 1994 54 (10) 2821-2821;