Table of Contents

Articles

• Advances in Brief

  Seminal Ribonuclease Inhibits Tumor Growth and Reduces the Metastatic Potential of Lewis Lung Carcinoma

  Paolo Laccetti, Daniela Spalletti-Cernia, Giuseppe Portella, Paola De Corato, Giuseppe D'Alessio and Giancarlo Vecchio

  Cancer Res August 15 1994 54 (16) 4253-4256;

  
  
• Advances in Brief

  Increased Copy Number at 20q13 in Breast Cancer: Defining the Critical Region and Exclusion of Candidate Genes

  Minna M. Tanner, Mika Tirkkonen, Anne Kallioniemi, Colin Collins, Trond Stokke, Ritva Karhu, Dave Kowbel, Feridan Shadravan, Mary Hintz, Wen-Lin Kuo, Frederic M. Waldman, Jorma J. Isola, Joe W. Gray and Olli-P. Kallioniemi

  Cancer Res August 15 1994 54 (16) 4257-4260;

  
  
• Advances in Brief

  Suppression of Fibrosarcoma Metastasis by Elevated Expression of Manganese Superoxide Dismutase

  S. E. Safford, T. D. Oberley, M. Urano and D. K. St. Clair

  Cancer Res August 15 1994 54 (16) 4261-4265;

  
  
• Advances in Brief

  Gene Therapy Targeted by Radiation Preferentially Radiosensitizes Tumor Cells

  Ralph R. Weichselbaum, Dennis E. Hallahan, Michael A. Beckett, Helena J. Mauceri, Henry Lee, Vikas P. Sukhatme and Donald W. Kufe

  Cancer Res August 15 1994 54 (16) 4266-4269;

  
  
• Advances in Brief

  Antiproliferative Effects of Enediynes on AIDS-derived Kaposi's Sarcoma Cells

  Jacques Corbeil, Douglas D. Richman, Wolfgang Wrasidlo, K. C. Nicolaou and David J. Looney

  Cancer Res August 15 1994 54 (16) 4270-4273;

  
  
• Advances in Brief

  A Tumor Suppressor Gene on Chromosome 1p32-pter Controls the Amplification of MYC Family Genes in Breast Cancer

  Ivan Bièche, Marie-Hélène Champème and Rosette Lidereau

  Cancer Res August 15 1994 54 (16) 4274-4276;

  
  
• Advances in Brief

  ALL-1 Tandem Duplication in Acute Myeloid Leukemia with a Normal Karyotype Involves Homologous Recombination between Alu Elements

  Steven A. Schichman, Michael A. Caligiuri, Matthew P. Strout, Stephen L. Carter, Yansong Gu, Eli Canaani, Clara D. Bloomfield and Carlo M. Croce

  Cancer Res August 15 1994 54 (16) 4277-4280;

  
  
• Advances in Brief

  Prostatic Tumor Regrowth after Initially Successful Castration Therapy May Be Related to a Decreased Apoptotic Cell Death Rate

  Marene Landström, Jan-Erik Damber and Anders Bergh

  Cancer Res August 15 1994 54 (16) 4281-4284;

  
  
• Advances in Brief

  Unscheduled Expression of Cyclin B1 and Cyclin E in Several Leukemic and Solid Tumor Cell Lines

  Jianping Gong, Barbara Ardelt, Frank Traganos and Zbigniew Darzynkiewicz

  Cancer Res August 15 1994 54 (16) 4285-4288;

  
  
• Advances in Brief

  Simultaneous Analysis of DNA Replication and Apoptosis during Treatment of HL-60 Cells with Camptothecin and Hyperthermia and Mitogen Stimulation of Human Lymphocytes

  Xun Li, Frank Traganos and Zbigniew Darzynkiewicz

  Cancer Res August 15 1994 54 (16) 4289-4293;

  
  
• Advances in Brief

  Allelotype of Endometrial Carcinoma

  Takafumi Fujino, John I. Risinger, N. Keith Collins, Fu-shing Liu, Hiroshi Nishii, Hiroyuki Takahashi, Eva-Marie Westphal, J. Carl Barrett, Hiroshi Sasaki, Matthew F. Kohler, Andrew Berchuck and Jeff Boyd

  Cancer Res August 15 1994 54 (16) 4294-4298;

  
  
• Advances in Brief

  Amplification of Multiple Genes from Chromosomal Region 12q13-14 in Human Malignant Gliomas: Preliminary Mapping of the Amplicons Shows Preferential Involvement of CDK4, SAS, and MDM2

  Guido Reifenberger, Julia Reifenberger, Koichi Ichimura, Paul S. Meltzer and V. Peter Collins

  Cancer Res August 15 1994 54 (16) 4299-4303;

  
  
• Advances in Brief

  Distribution of Intestine-associated Lymphoid Tissue, Aberrant Crypt Foci, and Tumors in the Large Bowel of 1,2-Dimethylhydrazine-treated Mice

  John W. Carter, Hugh K. Lancaster, W. Elaine Hardman and Ivan L. Cameron

  Cancer Res August 15 1994 54 (16) 4304-4307;

  
  
• Advances in Brief

  Human Chromosome 3 Corrects Mismatch Repair Deficiency and Microsatellite Instability and Reduces N-Methyl-N′-nitro-N-nitrosoguanidine Tolerance in Colon Tumor Cells with Homozygous hMLH1 Mutation

  Minoru Koi, Asad Umar, Dharam P. Chauhan, Sajeev P. Cherian, John M. Carethers, Thomas A. Kunkei and C. Richard Boland

  Cancer Res August 15 1994 54 (16) 4308-4312;

  
  
• Perspectives in Cancer Research

  Glutathione-associated Enzymes in Anticancer Drug Resistance

  Kenneth D. Tew

  Cancer Res August 15 1994 54 (16) 4313-4320;

  
  
• Biochemistry and Biophysics

  Effect of Modulators on 5-Fluorouracil Metabolite Patterns in Murine Colon Carcinoma Determined by in Vitro ¹⁹F Nuclear Magnetic Resonance Spectroscopy

  Yvonne J. L. Kamm, Ivonne M. C. M. Rietjens, Jacques Vervoort, Arend Heerschap, Gert Rosenbusch, Henny P. Hofs and D. J. Theo Wagener

  Cancer Res August 15 1994 54 (16) 4321-4326;

  
  
• Carcinogenesis

  Structure-Activity Relationships of Isothiocyanates as Mechanism-based Inhibitors of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis in A/J Mice

  Ding Jiao, Karin I. Eklind, Chang-In Choi, Dhimant H. Desai, Shantu G. Amin and Fung-Lung Chung

  Cancer Res August 15 1994 54 (16) 4327-4333;

  
  
• Carcinogenesis

  Inflammation Is Responsible for the Development of Wound-induced Tumors in Chickens Infected with Rous Sarcoma Virus

  Manuela Martins-Green, Nancy Boudreau and Mina J. Bissell

  Cancer Res August 15 1994 54 (16) 4334-4341;

  
  
• Carcinogenesis

  p53 Tumor Suppressor Gene Mutation in Early Esophageal Precancerous Lesions and Carcinoma among High-Risk Populations in Henan, China

  Hongkun Gao, Li-Dong Wang, Qi Zhou, Jun-Yan Hong, Tong-Yuh Huang and Chung S. Yang

  Cancer Res August 15 1994 54 (16) 4342-4346;

  
  
• Clinical Investigations

  Phase I and Pharmacokinetic Study of the Camptothecin Derivative Irinotecan, Administered on a Weekly Schedule in Cancer Patients

  M. de Forni, R. Bugat, G. G. Chabot, S. Culine, J-M. Extra, A. Gouyette, I. Madelaine, M. E. Marty and A. Mathieu-Boué

  Cancer Res August 15 1994 54 (16) 4347-4354;

  
  
• Experimental Therapeutics

  Paclitaxel Inhibits Progression of Mitotic Cells to G₁ Phase by Interference with Spindle Formation without Affecting Other Microtubule Functions during Anaphase and Telephase

  Byron H. Long and Craig R. Fairchild

  Cancer Res August 15 1994 54 (16) 4355-4361;

  
  
• Experimental Therapeutics

  Radioimmunotherapy of Nude Mice Bearing a Human Interleukin 2 Receptor α-expressing Lymphoma Utilizing the α-emitting Radionuclide-conjugated Monoclonal Antibody ²¹²Bi-anti-Tac

  Frank Hartmann, Eva M. Horak, Kayhan Garmestani, Chuanchu Wu, Martin W. Brechbiel, Robert W. Kozak, J. Tso, Sheri A. Kosteiny, Otto A. Gansow, David L. Nelson and Thomas A. Waldmann

  Cancer Res August 15 1994 54 (16) 4362-4370;

  
  
• Experimental Therapeutics

  Extended Depletion of O⁶-Methylguanine-DNA Methyltransferase Activity following O⁶-Benzyl-2′-deoxyguanosine or O⁶-Benzylguanine Combined with Streptozotocin Treatment Enhances 1,3-Bis(2-chloroethyl)-1-nitrosourea Cytotoxicity

  Upendra K. Marathi, M. Eileen Dolan and Leonard C. Erickson

  Cancer Res August 15 1994 54 (16) 4371-4375;

  
  
• Experimental Therapeutics

  Monoclonal Antibody Delivery to Intraperitoneal Tumors in Rats: Effects of Route of Administration and Intraperitoneal Solution Osmolality

  Michael F. Flessner and Robert L. Dedrick

  Cancer Res August 15 1994 54 (16) 4376-4384;

  
  
• Experimental Therapeutics

  Comparative Gompertzian Analysis of Alterations of Tumor Growth Patterns

  Ioannis D. Bassukas

  Cancer Res August 15 1994 54 (16) 4385-4392;

  
  
• Experimental Therapeutics

  Efficacy and Toxicity of Ifosfamide Stereoisomers in an in Vivo Rat Mammary Carcinoma Model

  I.W. Wainer, C.P. Granvil, T. Wang and G. Batist

  Cancer Res August 15 1994 54 (16) 4393-4397;

  
  
• Experimental Therapeutics

  Efficient Transfer of Selectable and Membrane Reporter Genes in Hematopoietic Progenitor and Stem Cells Purified from Human Peripheral Blood

  M. Valtieri, R. Schirò, C. Chelucci, B. Masella, U. Testa, I. Casella, E. Montesoro, G. Mariani, H. J. Hassan and C. Peschle

  Cancer Res August 15 1994 54 (16) 4398-4404;

  
  
• Experimental Therapeutics

  Induction of M_r 78,000 Glucose-regulated Stress Protein in Poly(Adenosine Diphosphate-Ribose) Polymerase- and Nicotinamide Adenine Dinucleotide-deficient V79 Cell Lines and Its Relation to Resistance to the Topoisomerase II Inhibitor Etoposide

  Satadal Chatterjee, Ming-Fang Cheng, Sosamma J. Berger and Nathan A. Berger

  Cancer Res August 15 1994 54 (16) 4405-4411;

  
  
• Experimental Therapeutics

  Chemotherapy with [SP-4-3-(R)]-[1,1-Cyclobutanedicarboxylato(2-)](2-methyl-1,4-butanediamine-N,N′)platinum (CI-973, NK121) in Combination with Standard Agents against Murine Tumors in Vivo

  William L. Elliott, Billy J. Roberts, Curtis T. Howard and Wilbur R. Leopold III

  Cancer Res August 15 1994 54 (16) 4412-4418;

  
  
• Immunology

  Intrapleural Production of Interleukin 6 during Mesothelioma and Its Modulation by γ-Interferon Treatment

  Gianpaola Monti, Marie-Claude Jaurand, Isabelle Monnet, Pascale Chretien, Laure Saint-Etienne, Lin Zeng, Alain Portier, Philippe Devillier, Pierre Galanaud, Jean Bignon and Dominique Emilie

  Cancer Res August 15 1994 54 (16) 4419-4423;

  
  
• Immunology

  Characterization of Cloned Class I MHC-restricted, CD8⁺ Anti-Meth A Cytotoxic T-Lymphocytes: Recognition of an Epitope Derived from the Meth A gp110 Tumor Rejection Antigen

  Maria Antonia Fassanito, Douglas Loftus, Rita M. De Leo, Lloyd W. Law, Ettore Appella and Albert B. De Leo

  Cancer Res August 15 1994 54 (16) 4424-4429;

  
  
• Immunology

  Abnormal Cytokine Expression in Sézary and Adult T-Cell Leukemia Cells Correlates with the Functional Diversity between These T-Cell Malignancies

  Craig L. Tendler, Jack D. Burton, Jonathan Jaffe, David Danielpour, Michael Charley, J. Philip McCoy, Mark R. Pittelkow and Thomas A. Waldmann

  Cancer Res August 15 1994 54 (16) 4430-4435;

  
  
• Molecular Biology and Genetics

  In Vitro Mutational Spectrum of Aflatoxin B₁ in the Human Hypoxanthine Guanine Phosphoribosyltransferase Gene

  Neal F. Cariello, Lisa Cui and Thomas R. Skopek

  Cancer Res August 15 1994 54 (16) 4436-4441;

  
  
• Molecular Biology and Genetics

  Retrovirus-mediated Gene Transfer of Rat Glutathione S-Transferase Yc Confers Alkylating Drug Resistance in NIH 3T3 Mouse Fibroblasts

  Mona Greenbaum, Sylvain Létourneau, Homa Assar, Robyn L. Schecter, Gerald Batist and Denis Cournoyer

  Cancer Res August 15 1994 54 (16) 4442-4447;

  
  
• Molecular Biology and Genetics

  Hyperphosphorylation of p53 Induced by Okadaic Acid Attenuates Its Transcriptional Activation Function

  Wei Zhang, Craig McClain, Jyh-pyng Gau, Xiang-Yang D. Guo and Albert B. Deisseroth

  Cancer Res August 15 1994 54 (16) 4448-4453;

  
  
• Molecular Biology and Genetics

  Database and Software for the Analysis of Mutations in the Human p53 Gene

  Neal F. Cariello, Lisa Cui, Christophe Beroud and Thierry Soussi

  Cancer Res August 15 1994 54 (16) 4454-4460;

  
  
• Molecular Biology and Genetics

  Functional Analysis of the 5′-Flanking Region of the Human Gastrin-releasing Peptide Gene in Small Cell Lung Carcinoma Cell Lines

  Srinivasa R. Nagalla and Eliot R. Spindel

  Cancer Res August 15 1994 54 (16) 4461-4467;

  
  
• Molecular Biology and Genetics

  Deficiency of Queuine, a Highly Modified Purine Base, in Transfer RNAs from Primary and Metastatic Ovarian Malignant Tumors in Women

  Wlodzimierz Baranowski, Guy Dirheimer, Jerzy Andrezj Jakowicki and Gérard Keith

  Cancer Res August 15 1994 54 (16) 4468-4471;

  
  
• Molecular Biology and Genetics

  Interphase Cytogenetic Analysis of Prostatic Carcinomas by Use of Nonisotopic in Situ Hybridization

  Gustavo Bruno Baretton, Christian Valina, Thomas Vogt, Karin Schneiderbanger, Joachim Diebold and Udo Löhrs

  Cancer Res August 15 1994 54 (16) 4472-4480;

  
  
• Molecular Biology and Genetics

  Allelotype Analysis of Cervical Carcinoma

  A. B. Mitra, V. V. V. S. Murty, Rong G. Li, Mahendra Pratap, Usha K. Luthra and R. S. K. Chaganti

  Cancer Res August 15 1994 54 (16) 4481-4487;

  
  
• Molecular Biology and Genetics

  Cloning and Sequence Analysis of the Promoter Region of the MRP Gene of HL60 Cells Isolated for Resistance to Adriamycin

  Qichao Zhu and Melvin S. Center

  Cancer Res August 15 1994 54 (16) 4488-4492;

  
  
• Molecular Biology and Genetics

  Expression and Alternative Splicing of the Deleted in Colorectal Cancer (DCC) Gene in Normal and Malignant Tissues

  Michael A. Reale, Gang Hu, Abrahim I. Zafar, Robert H. Getzenberg, Stuart M. Levine and Eric R. Fearon

  Cancer Res August 15 1994 54 (16) 4493-4501;

  
  
• Molecular Biology and Genetics

  3-Methylcholanthrene Inactivates the p53 Gene in Syrian Hamster Embryo Fibroblasts by Inducing a Specific Intronic Point Mutation

  Amador Albor, Denise M. Flessate, Thierry Soussi and Vicente Notario

  Cancer Res August 15 1994 54 (16) 4502-4507;

  
  
• Molecular Biology and Genetics

  PML/RARα⁺ U937 Mutant and NB4 Cell Lines: Retinoic Acid Restores the Monocytic Differentiation Response to Vitamin D₃

  Ugo Testa, Francesco Grignani, Tiziano Barberi, Marta Fagioli, Rosalba Masciulli, Pier Francesco Ferrucci, Davide Seripa, Antonio Camagna, Myriam Alcalay, Pier Giuseppe Pelicci and Cesare Peschle

  Cancer Res August 15 1994 54 (16) 4508-4515;

  
  
• Tumor Biology

  Hyaluronan Receptors Are Expressed on Human Malignant Mesothelioma Cells but not on Normal Mesothelial Cells

  Tomas Asplund and Paraskevi Heldin

  Cancer Res August 15 1994 54 (16) 4516-4523;

  
  
• Tumor Biology

  Capacity of Individual Chronic Lymphatic Leukemia Lymphocytes and Leukemic Blast Cells for Repair of O⁶-Ethylguanine in DNA: Relation to Chemosensitivity in Vitro and Treatment Outcome

  Mark R. Müller, Frank Seiler, Jürgen Thomale, Claudia Buschfort, Manfred F. Rajewsky and Siegfried Seeber

  Cancer Res August 15 1994 54 (16) 4524-4531;

  
  
• Tumor Biology

  Integrins and Laminins in Human Renal Carcinoma Cells and Tumors Grown in Nude Mice

  Matti Korhonen, Hannu Sariola, Victor E. Gould, Lauri Kangas and Ismo Virtanen

  Cancer Res August 15 1994 54 (16) 4532-4538;

  
  
• Tumor Biology

  Normal Human Tissues, in Addition to Some Tumors, Express Multiple Different CD44 Isoforms

  Stephen B. Fox, Jonathan Fawcett, David G. Jackson, Ian Collins, Kevin C. Gatter, Adrian L. Harris, Andrew Gearing and David L. Simmons

  Cancer Res August 15 1994 54 (16) 4539-4546;

  
  
• Tumor Biology

  Plasminogen Activation in Melanocytic Neoplasia

  Catherine Delbaldo, Isabelle Masouye, Jean-Hilaire Saurat, Jean-Dominique Vassalli and André-Pascal Sappino

  Cancer Res August 15 1994 54 (16) 4547-4552;

  
  
• Articles

  Announcements

  Cancer Res August 15 1994 54 (16) 4553-4555;

  
  
• Articles

  Erratum

  Cancer Res August 15 1994 54 (16) 4555-4555;