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Advances in Brief

Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells

Deborah K. Armstrong, Scott H. Kaufmann, Yvonne L. Ottaviano, Yuzo Furuya, Julie A. Buckley, John T. Isaacs and Nancy E. Davidson
Deborah K. Armstrong
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Scott H. Kaufmann
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Yvonne L. Ottaviano
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Yuzo Furuya
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Julie A. Buckley
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John T. Isaacs
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Nancy E. Davidson
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DOI:  Published October 1994
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Abstract

MDA-MB-468 human breast cancer cells lack estrogen receptors, over-express epidermal growth factor (EGF) receptors, and are growth inhibited by EGF. We show that treatment of MDA-MB-468 cells with EGF leads to inhibition of cell proliferation, fragmentation of DNA into nucleosomal oligomers, and the development of apoptotic morphology. This treatment is associated with increased expression of c-myc, c-fos, jun family members, and transforming growth factor β1 mRNA and with partial proteolytic cleavage of poly(ADP-ribose) polymerase and lamin B. The observation that EGF can mediate apoptosis in EGF receptor-over-expressing cells has important implications for clinical efforts directed at the EGF receptor.

Footnotes

  • ↵1 These studies have been supported by NIH Grant CA 57545 (to N. E. D.) and the Susan G. Komen Foundation (to D. K. A.). S. H. K. is a Leukemia Society Scholar.

  • ↵2 To whom requests for reprints should be addressed, at Johns Hopkins Oncology Center, 422 N. Bond Street, Baltimore, MD 21231.

  • Received July 15, 1994.
  • Accepted August 23, 1994.
  • ©1994 American Association for Cancer Research.
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October 1994
Volume 54, Issue 20
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Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells
Deborah K. Armstrong, Scott H. Kaufmann, Yvonne L. Ottaviano, Yuzo Furuya, Julie A. Buckley, John T. Isaacs and Nancy E. Davidson
Cancer Res October 15 1994 (54) (20) 5280-5283;

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Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells
Deborah K. Armstrong, Scott H. Kaufmann, Yvonne L. Ottaviano, Yuzo Furuya, Julie A. Buckley, John T. Isaacs and Nancy E. Davidson
Cancer Res October 15 1994 (54) (20) 5280-5283;
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