Abstract
The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PCAs are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.
Footnotes
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↵1 These studies were supported in part by Grant 92B28 from the American Institute for Cancer Research and by Grants CA48032, CA43703, CA57179, CA39207, and CA54031 from the National Cancer Institute and Grant DK45770 from the National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Department of Health and Human Services.
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↵2 To whom requests for reprints should be addressed, at Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44016.
- Received August 16, 1994.
- Accepted October 20, 1994.
- ©1994 American Association for Cancer Research.
Volume 54, Issue 23
