Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • Log out
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Advances in Brief

CWR22: Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma

Mark A. Wainstein, Feng He, Daniel Robinson, Hsing-Jien Kung, Stuart Schwartz, Joseph M. Giaconia, Nancy L. Edgehouse, Theresa P. Pretlow, Donald R. Bodner, Elroy D. Kursh, Martin I. Resnick, Allen Seftel and Thomas G. Pretlow
Mark A. Wainstein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Feng He
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Robinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hsing-Jien Kung
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stuart Schwartz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph M. Giaconia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nancy L. Edgehouse
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Theresa P. Pretlow
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Donald R. Bodner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elroy D. Kursh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin I. Resnick
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Allen Seftel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas G. Pretlow
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published December 1994
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PCAs are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.

Footnotes

  • ↵1 These studies were supported in part by Grant 92B28 from the American Institute for Cancer Research and by Grants CA48032, CA43703, CA57179, CA39207, and CA54031 from the National Cancer Institute and Grant DK45770 from the National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Department of Health and Human Services.

  • ↵2 To whom requests for reprints should be addressed, at Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44016.

  • Received August 16, 1994.
  • Accepted October 20, 1994.
  • ©1994 American Association for Cancer Research.
PreviousNext
Back to top
December 1994
Volume 54, Issue 23
  • Table of Contents
  • Table of Contents (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
CWR22: Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
CWR22: Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma
Mark A. Wainstein, Feng He, Daniel Robinson, Hsing-Jien Kung, Stuart Schwartz, Joseph M. Giaconia, Nancy L. Edgehouse, Theresa P. Pretlow, Donald R. Bodner, Elroy D. Kursh, Martin I. Resnick, Allen Seftel and Thomas G. Pretlow
Cancer Res December 1 1994 (54) (23) 6049-6052;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
CWR22: Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma
Mark A. Wainstein, Feng He, Daniel Robinson, Hsing-Jien Kung, Stuart Schwartz, Joseph M. Giaconia, Nancy L. Edgehouse, Theresa P. Pretlow, Donald R. Bodner, Elroy D. Kursh, Martin I. Resnick, Allen Seftel and Thomas G. Pretlow
Cancer Res December 1 1994 (54) (23) 6049-6052;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Advances in Brief

  • Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
  • Recombinant Listeria Vaccines Containing PEST Sequences Are Potent Immune Adjuvants for the Tumor-Associated Antigen Human Papillomavirus-16 E7
  • Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion cDNA for Cancer Gene Immunotherapy
Show more Advances in Brief

Articles

  • The Role of Chimeric Paired Box Transcription Factors in the Pathogenesis of Pediatric Rhabdomyosarcoma
  • Role of TCL1 and ALL1 in Human Leukemias and Development
  • Laureate Citations
Show more Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement