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Molecular Biology and Genetics

Frequent Allelic Deletion at a Novel Locus on Chromosome 5 in Human Lung Cancer

Ilse Wieland and Malte Böhm
Ilse Wieland
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Malte Böhm
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DOI:  Published April 1994
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Abstract

Frequent allelic deletions in tumor cells are indicative of the inactivation of tumor suppressor genes. Recently, we isolated the single-copy sequence del-27 (I. Wieland, M. Böhm, and S. Bogatz, Proc. Natl. Acad. Sci. USA, 89: 9705–9709, 1992). Here we show that del-27 detects a restriction fragment length polymorphism that allows examination for loss of heterozygosity (LOH) in tumor specimens. LOH at the del-27 locus occurred in 57% (4 of 7) of the informative lung carcinomas independent of the histopathological differentiation grade. LOH for exon 11 of the APC gene occurred in 71% (5 of 7) of the informative cases but was not associated with LOH at the del-27 locus. The del-27 sequence was localized to chromosome 5p13–5q14, proximal to the MCC/APC region, using a somatic cell hybrid panel. Together with our previous finding that del-27 is deleted homozygously in a lung carcinoma cell line, these results suggest that del-27 is linked closely to a novel putative tumor suppressor gene.

Footnotes

  • ↵1 This work was supported by the Deutsche Forschungsgemeinschaft (SFB 354) and by the Bennigsen-Foerder-Preis to I. W.

  • ↵2 Recipient of a Deutsche Forschungsgemeinschaft-Habilitationsstipendium. To whom requests for reprints should be addressed.

  • ↵3 Urologische Klinik, Universitätsklinikum, Hufelandstrasse 55, 45122 Essen, Germany.

  • Received September 20, 1993.
  • Accepted January 25, 1994.
  • ©1994 American Association for Cancer Research.
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April 1994
Volume 54, Issue 7
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Frequent Allelic Deletion at a Novel Locus on Chromosome 5 in Human Lung Cancer
Ilse Wieland and Malte Böhm
Cancer Res April 1 1994 (54) (7) 1772-1774;

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Frequent Allelic Deletion at a Novel Locus on Chromosome 5 in Human Lung Cancer
Ilse Wieland and Malte Böhm
Cancer Res April 1 1994 (54) (7) 1772-1774;
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