Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Tumor Biology

The Insulin-like Growth Factor I Receptor Protects Tumor Cells from Apoptosis in Vivo

Mariana Resnicoff, David Abraham, Wiboonchai Yutanawiboonchai, Harris L. Rotman, Jan Kajstura, Raphael Rubin, Philip Zoltick and Renato Baserga
Mariana Resnicoff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Abraham
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wiboonchai Yutanawiboonchai
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harris L. Rotman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Kajstura
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raphael Rubin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philip Zoltick
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Renato Baserga
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published June 1995
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantable tumors, either from humans or rodents. Conversely, an overexpressed IGF-IR protects cells from apoptosis in vivo. We also show that the same conditions that in vitro cause only partial growth arrest with a minimum of cell death, induce in vivo almost complete cell death. We conclude that the IGF-IR activated by its ligands plays a very important protective role in programmed cell death, and that its protective action is even more striking in vivo than in vitro.

Footnotes

  • ↵1 This study was supported by grants from the National Institutes of Health (CA 53484 and GM 33694) and the Edna McConnell Clark Foundation.

  • ↵2 To whom requests for reprints should be addressed, at Jefferson Cancer Institute, Thomas Jefferson University, Bluemle Life Sciences Building, 233 South 10th Street, Room 624, Philadelphia, PA 19107.

  • Received January 19, 1995.
  • Accepted April 5, 1995.
  • ©1995 American Association for Cancer Research.
PreviousNext
Back to top
June 1995
Volume 55, Issue 11
  • Table of Contents
  • Table of Contents (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The Insulin-like Growth Factor I Receptor Protects Tumor Cells from Apoptosis in Vivo
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
The Insulin-like Growth Factor I Receptor Protects Tumor Cells from Apoptosis in Vivo
Mariana Resnicoff, David Abraham, Wiboonchai Yutanawiboonchai, Harris L. Rotman, Jan Kajstura, Raphael Rubin, Philip Zoltick and Renato Baserga
Cancer Res June 1 1995 (55) (11) 2463-2469;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The Insulin-like Growth Factor I Receptor Protects Tumor Cells from Apoptosis in Vivo
Mariana Resnicoff, David Abraham, Wiboonchai Yutanawiboonchai, Harris L. Rotman, Jan Kajstura, Raphael Rubin, Philip Zoltick and Renato Baserga
Cancer Res June 1 1995 (55) (11) 2463-2469;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Tumor Biology

  • Abstract 6119: RNAi rat models for drug discovery
  • Abstract 3834: Histone methyltransferase SET8 is regulated by miR-192/-215 and induces oncogene-induced senescence via p53-dependent DNA damage in human gastric carcinoma cells
  • Abstract 3788: CircHMGCS1 interacts with RNA binding protein HuR and maintains stem-like cells in gliomas
Show more Tumor Biology

Articles

  • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
  • The Prizes
  • Role of TCL1 and ALL1 in Human Leukemias and Development
Show more Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement