Table of Contents

Articles

• Advances in Brief

  Loss of Expression of the p16/Cyclin-dependent Kinase Inhibitor 2 Tumor Suppressor Gene in Melanocytic Lesions Correlates with Invasive Stage of Tumor Progression

  Jon A. Reed, Frank Loganzo Jr., Christopher R. Shea, Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Jennifer K. Bogdany, Monica J. Shiel, Frank G. Haluska, Jane W. Fountain and Anthony P. Albino

  Cancer Res July 1 1995 55 (13) 2713-2718;

  
  
• Advances in Brief

  Evidence against Dominant Negative Mechanisms of Intestinal Polyp Formation by Apc Gene Mutations

  Masanobu Oshima, Hiroko Oshima, Masahiko Kobayashi, Masahiro Tsutsumi and Makoto M. Taketo

  Cancer Res July 1 1995 55 (13) 2719-2722;

  
  
• Advances in Brief

  Transcriptional Activation of the Proto-oncogene c-jun by Asbestos and H₂O₂ Is Directly Related to Increased Proliferation and Transformation of Tracheal Epithelial Cells

  Cynthia R. Timblin, Yvonne W. M. Janssen and Brooke T. Mossman

  Cancer Res July 1 1995 55 (13) 2723-2726;

  
  
• Advances in Brief

  A Variant Glucocorticoid Receptor Messenger RNA Is Expressed in Multiple Myeloma Patients

  Nancy L. Krett, Shafali Pillay, Pamela A. Moalli, Philip R. Greipp and Steven T. Rosen

  Cancer Res July 1 1995 55 (13) 2727-2729;

  
  
• Advances in Brief

  Expression of B7-1 by Highly Metastatic Mouse T Lymphomas Induces Optimal Natural Killer Cell-mediated Cytotoxicity

  Anja B. Geldhof, Geert Raes, Marleen Bakkus, Sophie Devos, Kris Thielemans and Patrick De Baetselier

  Cancer Res July 1 1995 55 (13) 2730-2733;

  
  
• Advances in Brief

  Telomerase Activity in Human Liver Tissues: Comparison between Chronic Liver Disease and Hepatocellular Carcinomas

  Hidetoshi Tahara, Toshio Nakanishi, Mikiya Kitamoto, Ryo Nakashio, Jerry W. Shay, Eiichi Tahara, Goro Kajiyama and Toshinori Ide

  Cancer Res July 1 1995 55 (13) 2734-2736;

  
  
• Advances in Brief

  Mch2, a New Member of the Apoptotic Ced-3/Ice Cysteine Protease Gene Family

  Teresa Fernandes-Alnemri, Gerald Litwack and Emad S. Alnemri

  Cancer Res July 1 1995 55 (13) 2737-2742;

  
  
• Advances in Brief

  Ovarian Carcinoma-associated TaqI Restriction Fragment Length Polymorphism in Intron G of the Progesterone Receptor Gene Is Due to an Alu Sequence Insertion

  Susan M. Rowe, Sorcha J. Coughlan, Neil J. McKenna, Elaine Garrett, Dirk G. Kieback, Desmond N. Carney and Denis R. Headon

  Cancer Res July 1 1995 55 (13) 2743-2745;

  
  
• Advances in Brief

  Loss of Wild-Type p53 Bestows a Growth Advantage on Primary Cortical Astrocytes and Facilitates Their in Vitro Transformation

  Oliver Bögler, H-J. Su Huang and Webster K. Cavenee

  Cancer Res July 1 1995 55 (13) 2746-2751;

  
  
• Advances in Brief

  Overexpression of the Focal Adhesion Kinase (p125^FAK) in Invasive Human Tumors

  Lewis V. Owens, LiHui Xu, Rolf J. Craven, Georgette A. Dent, Tim M. Weiner, Lori Kornberg, Edison T. Liu and William G. Cance

  Cancer Res July 1 1995 55 (13) 2752-2755;

  
  
• Advances in Brief

  Mutations of p16^Ink4/CDKN2 and p15^Ink4B/MTS2 Genes in Biliary Tract Cancers

  Sadao Yoshida, Takeshi Todoroki, Yoshihito Ichikawa, Shuji Hanai, Hiromichi Suzuki, Mitsuo Hori, Katashi Fukao, Masanao Miwa and Kazuhiko Uchida

  Cancer Res July 1 1995 55 (13) 2756-2760;

  
  
• Special Lecture

  Initiatives with Platinum- and Quinazoline-based Antitumor Molecules—Fourteenth Bruce F. Cain Memorial Award Lecture

  Ken R. Harrap

  Cancer Res July 1 1995 55 (13) 2761-2768;

  
  
• Carcinogenesis

  Mucosa-preferential DNA Adduct Formation by 2-Amino-3-methylimidazo-[4,5-f]quinoline in the Rat Colonic Wall

  Aiichiro Kajikawa, Atsushi Umemoto, Kunimi Hamada, Masaki Tanaka, Takemi Kinouchi, Yoshinari Ohnishi and Yasumasa Monden

  Cancer Res July 1 1995 55 (13) 2769-2773;

  
  
• Carcinogenesis

  Mouse Skin Tumor Progression Results in Differential Expression of Retinoic Acid and Retinoid X Receptors

  Nadine Darwiche, Giulia Celli, Tamar Tennenbaum, Adam B. Glick, Stuart H. Yuspa and Luigi M. De Luca

  Cancer Res July 1 1995 55 (13) 2774-2782;

  
  
• Clinical Investigations

  G_M2-KLH Conjugate Vaccine: Increased Immunogenicity in Melanoma Patients after Administration with Immunological Adjuvant QS-21

  Friedhelm Helling, Shengle Zhang, Ann Shang, Sucharita Adluri, Michele Calves, Rao Koganty, B. Michael Longenecker, Tzy-J. Yao, Herbert F. Oettgen and Philip O. Livingston

  Cancer Res July 1 1995 55 (13) 2783-2788;

  
  
• Clinical Investigations

  Glutathione S-Transferase Activity and Glutathione S-Transferase μ Expression in Subjects with Risk for Colorectal Cancer

  Christine E. Szarka, Gordon R. Pfeiffer, Susan T. Hum, Lynette C. Everley, Andrew M. Balshem, Dirk F. Moore, Samuel Litwin, Eric B. Goosenberg, Harold Frucht, Paul F. Engstrom and Margie L. Clapper

  Cancer Res July 1 1995 55 (13) 2789-2793;

  
  
• Experimental Therapeutics

  Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)-malononitrile], Inhibits Cell Growth by Disrupting Mitochondria

  Angelika M. Burger, Gurmeet Kaur, Michael C. Alley, Jeffrey G. Supko, Louis Malspeis, Michael R. Grever and Edward A. Sausville

  Cancer Res July 1 1995 55 (13) 2794-2799;

  
  
• Experimental Therapeutics

  The Interaction of Hydroxyurea and Iododeoxyuridine on the Radiosensitivity of Human Bladder Cancer Cells

  Mei-Ling Kuo, Keith A. Kunugi, Mary J. Lindstrom and Timothy J. Kinsella

  Cancer Res July 1 1995 55 (13) 2800-2805;

  
  
• Experimental Therapeutics

  Antitumor Activities of a New Indolocarbazole Substance, NB-506, and Establishment of NB-506-resistant Cell Lines, SBC-3/NB

  Fumihiko Kanzawa, Kazuto Nishio, Naohiro Kubota and Nagahiro Saijo

  Cancer Res July 1 1995 55 (13) 2806-2813;

  
  
• Experimental Therapeutics

  Mechanism of Action of the Antineoplastic Drug Lonidamine: ³¹P and ¹³C Nuclear Magnetic Resonance Studies

  Hava Ben-Horin, Maria Tassini, Antonio Vivi, Gil Navon and Ofer Kaplan

  Cancer Res July 1 1995 55 (13) 2814-2821;

  
  
• Experimental Therapeutics

  20-epi-Vitamin D₃ Analogues: A Novel Class of Potent Inhibitors of Proliferation and Inducers of Differentiation of Human Breast Cancer Cell Lines

  Elena Elstner, Marjane Linker-Israeli, Johnathan Said, Tehila Umiel, Sven de Vos, I. Peter Shintaku, David Heber, Lise Binderup, Milan Uskokovic and H. Phillip Koeffler

  Cancer Res July 1 1995 55 (13) 2822-2830;

  
  
• Experimental Therapeutics

  Application of a Tumor Suppressor (C-CAM1)-expressing Recombinant Adenovirus in Androgen-independent Human Prostate Cancer Therapy: A Preclinical Study

  David I. Kleinerman, Wei-Wei Zhang, Sue-Hwa Lin, Nguyen T. Van, Andrew C. von Eschenbach and Jer-Tsong Hsieh

  Cancer Res July 1 1995 55 (13) 2831-2836;

  
  
• Experimental Therapeutics

  Effect of the Chemoprotective Agent WR-2721 on Disposition and Biotransformations of Ormaplatin in the Fischer 344 Rat Bearing a Fibrosarcoma

  D. Charles Thompson, Steven D. Wyrick, David J. Holbrook and Stephen G. Chaney

  Cancer Res July 1 1995 55 (13) 2837-2846;

  
  
• Experimental Therapeutics

  Metabolism and Actions of 2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-adenine in Human Lymphoblastoid Cells

  Chunxi Xie and William Plunkett

  Cancer Res July 1 1995 55 (13) 2847-2852;

  
  
• Experimental Therapeutics

  Activity of Temozolomide in the Treatment of Central Nervous System Tumor Xenografts

  Henry S. Friedman, M. Eileen Dolan, Anthony E. Pegg, Susan Marcelli, Stephen Keir, Joseph J. Catino, Darell D. Bigner and S. Clifford Schold Jr.

  Cancer Res July 1 1995 55 (13) 2853-2857;

  
  
• Immunology

  Improved Tumor Radioimmunodetection Using a Single-Chain Fv and γ-Interferon: Potential Clinical Applications for Radioimmunoguided Surgery and γ Scanning

  Carol A. Nieroda, Diane E. Milenic, Jorge A. Carrasquillo, Jeffrey Schlom and John W. Greiner

  Cancer Res July 1 1995 55 (13) 2858-2865;

  
  
• Molecular Biology and Genetics

  Somatic Mutations Detected by Mini- and Microsatellite DNA Markers Reveal Clonal Intratumor Heterogeneity in Gastrointestinal Cancers

  Susanne Nagel, Bettina Borisch, Swee Lay Thein, Madeleine Oestreicher, Fritz Nöthiger, Stefan Birrer, Andreas Tobler and Martin F. Fey

  Cancer Res July 1 1995 55 (13) 2866-2870;

  
  
• Molecular Biology and Genetics

  Loss of Heterozygosity of Tumor Suppressor Genes in Testis Cancer

  Hong-Qi Peng, Denis Bailey, David Bronson, Paul E. Goss and David Hogg

  Cancer Res July 1 1995 55 (13) 2871-2875;

  
  
• Molecular Biology and Genetics

  Frequent Detection of bcl-2/J_H Translocations in Human Blood and Organ Samples by a Quantitative Polymerase Chain Reaction Assay

  Weizhen Ji, Guang-zhi Qu, Peng Ye, Xian-Yang Zhang, Susan Halabi and Melanie Ehrlich

  Cancer Res July 1 1995 55 (13) 2876-2882;

  
  
• Molecular Biology and Genetics

  Expression of a Deletion Mutant of the E2F1 Transcription Factor in Fibroblasts Lengthens S Phase and Increases Sensitivity to S Phase-specific Toxins

  Thomas J. Logan, Devon L. Evans, W. Edward Mercer, Mary-Ann Bjornsti and David J. Hall

  Cancer Res July 1 1995 55 (13) 2883-2891;

  
  
• Molecular Biology and Genetics

  Chromosome 9p Allelic Loss and p16/CDKN2 in Breast Cancer and Evidence of p16 Inactivation in Immortal Breast Epithelial Cells

  Andrew J. Brenner and C. Marcelo Aldaz

  Cancer Res July 1 1995 55 (13) 2892-2895;

  
  
• Molecular Biology and Genetics

  A Screening Method to Identify Genes Commonly Overexpressed in Carcinomas and the Identification of a Novel Complementary DNA Sequence

  Jennifer A. Byrne, Catherine Tomasetto, Jean-Marie Garnier, Nicolas Rouyer, Marie-Geneviève Mattei, Jean-Pierre Bellocq, Marie-Christine Rio and Paul Basset

  Cancer Res July 1 1995 55 (13) 2896-2903;

  
  
• Molecular Biology and Genetics

  Seven Megabase Yeast Artificial Chromosome Contig at Region 11p15: Identification of a Yeast Artificial Chromosome Spanning the Breakpoint of a Chromosomal Translocation Found in a Case of Beckwith-Wiedemann Syndrome

  Massimo Negrini, Silvia Sabbioni, Masataka Ohta, Maria Luisa Veronese, Shashi Rattan, Claudine Junien and Carlo M. Croce

  Cancer Res July 1 1995 55 (13) 2904-2909;

  
  
• Molecular Biology and Genetics

  Topological Control of p21^WAF1/CIP1 Expression in Normal and Neoplastic Tissues

  Wafik S. El-Deiry, Takashi Tokino, Todd Waldman, Jon D. Oliner, Victor E. Velculescu, Marilee Burrell, David E. Hill, Eugene Healy, Jonathan L. Rees, Stanley R. Hamilton, Kenneth W. Kinzler and Bert Vogelstein

  Cancer Res July 1 1995 55 (13) 2910-2919;

  
  
• Tumor Biology

  The α-Glucosidase I Inhibitor Castanospermine Alters Endothelial Cell Glycosylation, Prevents Angiogenesis, and Inhibits Tumor Growth

  Roberto Pili, Joan Chang, Richard A. Partis, Richard A. Mueller, Francis J. Chrest and Antonino Passaniti

  Cancer Res July 1 1995 55 (13) 2920-2926;

  
  
• Tumor Biology

  Cyclic AMP-regulated Synthesis of the Tissue Inhibitors of Metalloproteinases Suppresses the Invasive Potential of the Human Fibrosarcoma Cell Line HT1080

  Kazuhiro Tanaka, Yukihide Iwamoto, Yasumasa Ito, Toru Ishibashi, Yusaku Nakabeppu, Mutsuo Sekiguchi and Yoichi Sugioka

  Cancer Res July 1 1995 55 (13) 2927-2935;

  
  
• Tumor Biology

  Fas/APO-1 Gene Transfer for Human Malignant Glioma

  Michael Weller, Ursula Malipiero, Anne Rensing-Ehl, Philip J. Barr and Adriano Fontana

  Cancer Res July 1 1995 55 (13) 2936-2944;

  
  
• Articles

  Announcements

  Cancer Res July 1 1995 55 (13) 2945-2947;

  
  
• Articles

  Employment Register of the American Association for Cancer Research

  Cancer Res July 1 1995 55 (13) 2948-2957;