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Advances in Brief

Frequent Expression of a Mutant Epidermal Growth Factor Receptor in Multiple Human Tumors

David K. Moscatello, Marina Holgado-Madruga, Andrew K. Godwin, Gloria Ramirez, George Gunn, Philip W. Zoltick, Jaclyn A. Biegel, Roberta L. Hayes and Albert J. Wong
David K. Moscatello
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Marina Holgado-Madruga
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Andrew K. Godwin
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Gloria Ramirez
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George Gunn
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Philip W. Zoltick
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Jaclyn A. Biegel
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Roberta L. Hayes
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Albert J. Wong
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DOI:  Published December 1995
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Abstract

The epidermal growth factor receptor has received much interest as a target for various antineoplastic agents, but a complication is that many normal tissues also express this receptor. We have previously identified in human glial tumors an 801-bp in-frame deletion within the epidermal growth factor receptor gene that created a novel epitope at the junction. By using Western blot assays with a mutant-specific antibody as a rapid and sensitive means for detecting this alteration in primary human tumors, it was found that 57% (26 of 46) of high-grade and 86% (6 of 7) of low-grade glial tumors, but not normal brain, express this protein. This altered receptor was also present in 66% (4 of 6) of pediatric gliomas and 86% (6 of 7) of medulloblastomas, 78% (21 of 27) of breast carcinomas, and 73% (24 of 32) of ovarian carcinomas. The fact that this receptor is frequently found in tumors but not in normal tissue makes it an attractive candidate for various antitumor strategies.

Footnotes

  • ↵1 This work was supported by CA-51093, NS-31102, and the Ronald McDonald Children's Charities Foundation.

  • ↵2 These two authors contributed equally to this work.

  • ↵3 To whom correspondence should be addressed, at Jefferson Cancer Institute, BLSB 1002, 233 South 10th Street, Philadelphia, PA 19107.

  • Received September 20, 1995.
  • Accepted October 19, 1995.
  • ©1995 American Association for Cancer Research.
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December 1995
Volume 55, Issue 23
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Frequent Expression of a Mutant Epidermal Growth Factor Receptor in Multiple Human Tumors
David K. Moscatello, Marina Holgado-Madruga, Andrew K. Godwin, Gloria Ramirez, George Gunn, Philip W. Zoltick, Jaclyn A. Biegel, Roberta L. Hayes and Albert J. Wong
Cancer Res December 1 1995 (55) (23) 5536-5539;

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Frequent Expression of a Mutant Epidermal Growth Factor Receptor in Multiple Human Tumors
David K. Moscatello, Marina Holgado-Madruga, Andrew K. Godwin, Gloria Ramirez, George Gunn, Philip W. Zoltick, Jaclyn A. Biegel, Roberta L. Hayes and Albert J. Wong
Cancer Res December 1 1995 (55) (23) 5536-5539;
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