Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • Log out
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Advances in Brief

Independent Amplification and Frequent Co-Amplification of Three Nonsyntenic Regions on the Long Arm of Chromosome 20 in Human Breast Cancer

Minna M. Tanner, Mika Tirkkonen, Anne Kallioniemi, Jorma Isola, Tuula Kuukasjärvi, Colin Collins, David Kowbel, Xin-Yuan Guan, Jeff Trent, Joe W. Gray, Paul Meltzer and Olli-P. Kallioniemi
Minna M. Tanner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mika Tirkkonen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne Kallioniemi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jorma Isola
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tuula Kuukasjärvi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Colin Collins
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Kowbel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xin-Yuan Guan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeff Trent
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joe W. Gray
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Meltzer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olli-P. Kallioniemi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published August 1996
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

DNA amplification at 20q13.2 is common in breast cancer, correlates with poor prognosis, and may reflect location of an important oncogene. Recently, other regions along 20q were also found to undergo amplification. Here, amplification levels and patterns of co-amplification were analyzed by interphase fluorescence in situ hybridization at 14 loci along 20q in 146 uncultured breast carcinomas and 14 cell lines. Three regions were independently amplified in uncultured tumors: RMC20C001 region at 20q13.2 (highly amplified in 9.6% of the cases), PTPN1 region 3 Mb proximal (6.2%), and AIB3 region at 20q11 (6.2%). Co-amplifications involving two or three of these regions were seen in 11 of the 19 highly amplified tumors. The results suggest that three distinct nonsyntenic regions along 20q may be important and that complex chromosomal rearrangements underlie their frequent co-amplification in breast cancer.

Footnotes

  • ↵1 This study was supported by grants from the Finnish Academy of Sciences, Finnish Cancer Society, Sigrid Juselius Foundation, the Medical Research Fund of Tampere University Hospital (to O. P. K. and J. I.); USPHS Grant CA58207, DOE Contract DE-AC-03-76SF00098, and Vysis, Inc. (to J. W. G.); and the Pirkanmaa Cancer Society, Pirkanmaa Cultural Foundation, Irja Karvonen Foundation, and the finnish Medical Foundation (to M. M. T.).

  • ↵2 To whom requests for reprints should be addressed. Fax: 358-31-2474168; E-mail:blmita@uta.fi.

  • Received May 3, 1996.
  • Accepted June 21, 1996.
  • ©1996 American Association for Cancer Research.
PreviousNext
Back to top
August 1996
Volume 56, Issue 15
  • Table of Contents
  • Table of Contents (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)

Sign up for alerts

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Independent Amplification and Frequent Co-Amplification of Three Nonsyntenic Regions on the Long Arm of Chromosome 20 in Human Breast Cancer
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Independent Amplification and Frequent Co-Amplification of Three Nonsyntenic Regions on the Long Arm of Chromosome 20 in Human Breast Cancer
Minna M. Tanner, Mika Tirkkonen, Anne Kallioniemi, Jorma Isola, Tuula Kuukasjärvi, Colin Collins, David Kowbel, Xin-Yuan Guan, Jeff Trent, Joe W. Gray, Paul Meltzer and Olli-P. Kallioniemi
Cancer Res August 1 1996 (56) (15) 3441-3445;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Independent Amplification and Frequent Co-Amplification of Three Nonsyntenic Regions on the Long Arm of Chromosome 20 in Human Breast Cancer
Minna M. Tanner, Mika Tirkkonen, Anne Kallioniemi, Jorma Isola, Tuula Kuukasjärvi, Colin Collins, David Kowbel, Xin-Yuan Guan, Jeff Trent, Joe W. Gray, Paul Meltzer and Olli-P. Kallioniemi
Cancer Res August 1 1996 (56) (15) 3441-3445;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

Advances in Brief

  • Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion cDNA for Cancer Gene Immunotherapy
  • NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response
  • Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis
Show more Advances in Brief

Articles

  • Intersections between Blood Cell Development and Leukemia Genes
  • Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis elegans
  • The Prizes
Show more Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement