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Advances in Brief

Tumor Oxygenation Predicts for the Likelihood of Distant Metastases in Human Soft Tissue Sarcoma

David M. Brizel, Sean P. Scully, John M. Harrelson, Lester J. Layfield, Joseph M. Bean, Leonard R. Prosnitz and Mark W. Dewhirst
David M. Brizel
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Sean P. Scully
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John M. Harrelson
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Lester J. Layfield
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Joseph M. Bean
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Leonard R. Prosnitz
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Mark W. Dewhirst
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DOI:  Published March 1996
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Abstract

This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmetastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia and pretreatment measurement of tumor oxygenation. The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of < 10 mm Hg (P = 0.01). There were eight treatment failures; the first site of recurrence was lung in all patients. Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P = 0.03). Potential mechanisms and implications for clinical trial design are discussed.

Footnotes

  • ↵1 This work was supported by NIH Grant CA42745.

  • ↵2 To whom requests for reprints should be addressed, at Department of Radiation Oncology, Box 3085, Duke University Medical Center, Durham, NC 27710. Phone: (919) 660-2119; Fax: (919) 684-3953; E-mail: brizel@radonc.duke.edu.

  • Received December 1, 1995.
  • Accepted January 17, 1996.
  • ©1996 American Association for Cancer Research.
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March 1996
Volume 56, Issue 5
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Tumor Oxygenation Predicts for the Likelihood of Distant Metastases in Human Soft Tissue Sarcoma
David M. Brizel, Sean P. Scully, John M. Harrelson, Lester J. Layfield, Joseph M. Bean, Leonard R. Prosnitz and Mark W. Dewhirst
Cancer Res March 1 1996 (56) (5) 941-943;

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Tumor Oxygenation Predicts for the Likelihood of Distant Metastases in Human Soft Tissue Sarcoma
David M. Brizel, Sean P. Scully, John M. Harrelson, Lester J. Layfield, Joseph M. Bean, Leonard R. Prosnitz and Mark W. Dewhirst
Cancer Res March 1 1996 (56) (5) 941-943;
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