Table of Contents

Articles

• Advances in Brief

  Characterization of Prostatic Epithelial Cell Lines Derived from Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Model

  Barbara A. Foster, Jeffrey R. Gingrich, Eugene D. Kwon, Christopher Madias and Norman M. Greenberg

  Cancer Res August 15 1997 57 (16) 3325-3330;

  
  
• Advances in Brief

  Drug-induced Apoptosis Is Associated with Enhanced Fas (Apo-1/CD95) Ligand Expression but Occurs Independently of Fas (Apo-1/CD95) Signaling in Human T-Acute Lymphatic Leukemia Cells

  Andreas Villunger, Alexander Egle, Marion Kos, Bernd L. Hartmann, Stephan Geley, Reinhard Kofler and Richard Greil

  Cancer Res August 15 1997 57 (16) 3331-3334;

  
  
• Advances in Brief

  The DNA Repair Protein O⁶-Methylguanine-DNA Methyltransferase Protects against Skin Tumor Formation Induced by Antineoplastic Chloroethylnitrosourea

  Klaus Becker, Cornelia M. Gregel and Bernd Kaina

  Cancer Res August 15 1997 57 (16) 3335-3338;

  
  
• Advances in Brief

  Development of an Adenovirus Vector with Tetracycline-regulatable Human Tumor Necrosis Factor α Gene Expression

  Shi-Xue Hu, Wan Ji, Yunli Zhou, Christopher Logothetis and Hong-Ji Xu

  Cancer Res August 15 1997 57 (16) 3339-3343;

  
  
• Advances in Brief

  Epothilone B Stabilizes Microtubuli of Macrophages Like Taxol without Showing Taxol-like Endotoxin Activity

  Peter F. Mühlradt and Florenz Sasse

  Cancer Res August 15 1997 57 (16) 3344-3346;

  
  
• Advances in Brief

  Methylation of the BRCA1 Gene in Sporadic Breast Cancer

  Alexander Dobrovic and David Simpfendorfer

  Cancer Res August 15 1997 57 (16) 3347-3350;

  
  
• Advances in Brief

  A BRCA1 Mutant Alters G₂-M Cell Cycle Control in Human Mammary Epithelial Cells

  Jeffrey S. Larson, John L. Tonkinson and Mei T. Lai

  Cancer Res August 15 1997 57 (16) 3351-3355;

  
  
• Advances in Brief

  Loss of Heterozygosity at 16q24.1–q24.2 Is Significantly Associated with Metastatic and Aggressive Behavior of Prostate Cancer

  Jussi P. Elo, Päivi Härkönen, Atte P. Kyllönen, Olavi Lukkarinen, Matti Poutanen, Reijo Vihko and Pirkko Vihko

  Cancer Res August 15 1997 57 (16) 3356-3359;

  
  
• Advances in Brief

  Two- and Three-dimensional Cell Structures Govern Epidermal Growth Factor Survival Function in Human Bladder Carcinoma Cell Lines

  Virginie Dangles, Françoise Féménia, Véronique Lainé, Madeleine Berthelemy, Danielle Le Rhun, Marie-France Poupon, Daniel Levy and Isabelle Schwartz-Cornil

  Cancer Res August 15 1997 57 (16) 3360-3364;

  
  
• Advances in Brief

  Nitric Oxide Induces Conformational and Functional Modifications of Wild-Type p53 Tumor Suppressor Protein

  Sylvie Calmels, Pierre Hainaut and Hiroshi Ohshima

  Cancer Res August 15 1997 57 (16) 3365-3369;

  
  
• Advances in Brief

  Association between CpG Island Methylation and Microsatellite Instability in Colorectal Cancer

  Nita Ahuja, Avinash L. Mohan, Qing Li, Joshua M. Stolker, James G. Herman, Stanley R. Hamilton, Stephen B. Baylin and Jean-Pierre J. Issa

  Cancer Res August 15 1997 57 (16) 3370-3374;

  
  
• Advances in Brief

  Cytotoxic Synergy between Flavopiridol (NSC 649890, L86-8275) and Various Antineoplastic Agents: The Importance of Sequence of Administration

  Keith C. Bible and Scott H. Kaufmann

  Cancer Res August 15 1997 57 (16) 3375-3380;

  
  
• Advances in Brief

  Prognostic Role of the Cyclin-dependent Kinase Inhibitor p27 in Non-Small Cell Lung Cancer

  Vincenzo Esposito, Alfonso Baldi, Antonio De Luca, Angela M. Groger, Massimo Loda, Giovan Giacomo Giordano, Mario Caputi, Feliciano Baldi, Michele Pagano and Antonio Giordano

  Cancer Res August 15 1997 57 (16) 3381-3385;

  
  
• Advances in Brief

  Dissociation of Radiation-induced Phosphorylation of Replication Protein A from the S-Phase Checkpoint

  Susan E. Morgan and Michael B. Kastan

  Cancer Res August 15 1997 57 (16) 3386-3389;

  
  
• Advances in Brief

  A p53-independent Pathway for Induction of p21^waf1cip1 and Concomitant G₁ Arrest in UV-irradiated Human Skin Fibroblasts

  Martin Loignon, Raouf Fetni, Alasdair J. E. Gordon and Elliot A. Drobetsky

  Cancer Res August 15 1997 57 (16) 3390-3394;

  
  
• Biochemistry and Biophysics

  Effect of the Chimeric Soluble Granulocyte Colony-stimulating Factor Receptor on the Proliferation of Leukemic Blast Cells from Patients with Acute Myeloblastic Leukemia

  Yoshinobu Asano, Toshihiro Yokoyama, Shoichiro Shibata, Shinji Kobayashi, Kazuya Shimoda, Hitoshi Nakashima, Seiichi Okamura and Yoshiyuki Niho

  Cancer Res August 15 1997 57 (16) 3395-3397;

  
  
• Biochemistry and Biophysics

  The Classification of Benign and Malignant Human Prostate Tissue by Multivariate Analysis of ¹H Magnetic Resonance Spectra

  Per Hahn, Ian C. P. Smith, Leonard Leboldus, Charles Littman, Ray L. Somorjai and Tedros Bezabeh

  Cancer Res August 15 1997 57 (16) 3398-3401;

  
  
• Biochemistry and Biophysics

  CYP2D6 Catalyzes Tamoxifen 4-Hydroxylation in Human Liver

  Shangara S. Dehal and David Kupfer

  Cancer Res August 15 1997 57 (16) 3402-3406;

  
  
• Biochemistry and Biophysics

  Biochemical Characterization of the Protein Activity Responsible for High Molecular Weight DNA Fragmentation during Drug-induced Apoptosis

  Peng Huang, Kalpana Ballal and William Plunkett

  Cancer Res August 15 1997 57 (16) 3407-3414;

  
  
• Biochemistry and Biophysics

  Pharmacokinetic Analysis of 5-[¹⁸F]Fluorouracil Tissue Concentrations Measured with Positron Emission Tomography in Patients with Liver Metastases from Colorectal Adenocarcinoma

  Jutta Kissel, Gunnar Brix, Matthias E. Bellemann, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Rüdiger Port, Uwe Haberkorn and Walter J. Lorenz

  Cancer Res August 15 1997 57 (16) 3415-3423;

  
  
• Carcinogenesis

  Cancer Chemopreventive Activity Mediated by Deguelin, a Naturally Occurring Rotenoid

  George O. Udeani, Clarissa Gerhäuser, Cathy F. Thomas, Richard C. Moon, Jerrome W. Kosmeder, A. Douglas Kinghorn, Robert M. Moriarty and John M. Pezzuto

  Cancer Res August 15 1997 57 (16) 3424-3428;

  
  
• Carcinogenesis

  Regulation of Ornithine Decarboxylase Induction by Deguelin, a Natural Product Cancer Chemopreventive Agent

  Clarissa Gerhäuser, Sang Kook Lee, Jerry W. Kosmeder, Robert M. Moriarty, Ernest Hamel, Rajendra G. Mehta, Richard C. Moon and John M. Pezzuto

  Cancer Res August 15 1997 57 (16) 3429-3435;

  
  
• Carcinogenesis

  Evidence That Cutaneous Carcinogen-initiated Epithelial Cells from Mice Are Quiescent Rather Than Actively Cycling

  Rebecca J. Morris, Kathleen Coulter, Kimberly Tryson and Sharon R. Steinberg

  Cancer Res August 15 1997 57 (16) 3436-3443;

  
  
• Carcinogenesis

  Retinyl Methyl Ether Down-Regulates Activator Protein 1 Transcriptional Activation in Breast Cancer Cells

  Anissa Agadir, Y. Fulmer Shealy, Donald L. Hill and Xiao-kun Zhang

  Cancer Res August 15 1997 57 (16) 3444-3450;

  
  
• Carcinogenesis

  Specific Chromosomal Changes in Albumin Simian Virus 40 T Antigen Transgenic Rat Liver Neoplasms

  Linda M. Sargent, Yvonne P. Dragan, Gerald Sattler, Yi-Hua Xu, John Wiley and Henry C. Pitot

  Cancer Res August 15 1997 57 (16) 3451-3456;

  
  
• Carcinogenesis

  Urinary Excretion of Unmetabolized and Phase II Conjugates of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Humans: Relationship to Cytochrome P4501A2 and N-Acetyltransferase Activity

  W. G. Stillwell, La Creis R. Kidd, John S. Wishnok, Steven R. Tannenbaum and Rashmi Sinha

  Cancer Res August 15 1997 57 (16) 3457-3464;

  
  
• Carcinogenesis

  Dietary Fat and Colon Cancer: Modulation of Cyclooxygenase-2 by Types and Amount of Dietary Fat during the Postinitiation Stage of Colon Carcinogenesis

  Jagveer Singh, Rachid Hamid and Bandaru S. Reddy

  Cancer Res August 15 1997 57 (16) 3465-3470;

  
  
• Carcinogenesis

  p53 Mutations, Chronic Hepatitis B Virus Infection, and Alfatoxin Exposure in Hepatocellular Carcinoma in Taiwan

  Ruth M. Lunn, Yu-Jing Zhang, Li-Yu Wang, Chien-Jen Chen, Po-Huang Lee, Chue-Shue Lee, Wei-Yann Tsai and Regina M. Santella

  Cancer Res August 15 1997 57 (16) 3471-3477;

  
  
• Endocrinology

  A Functional Assay in Yeast for the Human Estrogen Receptor Displays Wild-Type and Variant Estrogen Receptor Messenger RNAs Present in Breast Carcinoma

  Mariska A. J. van Dijk, Arno N. Floore, Kim I. M. Kloppenborg and Laura J. van't Veer

  Cancer Res August 15 1997 57 (16) 3478-3485;

  
  
• Endocrinology

  MCF7/LCC9: An Antiestrogen-resistant MCF-7 Variant in Which Acquired Resistance to the Steroidal Antiestrogen ICI 182,780 Confers an Early Cross-Resistance to the Nonsteroidal Antiestrogen Tamoxifen

  Nils Brünner, Birgitte Boysen, Stana Jirus, Todd C. Skaar, Claus Holst-Hansen, Jeremy Lippman, Thomas Frandsen, Mogens Spang-Thomsen, Suzanne A. W. Fuqua and Robert Clarke

  Cancer Res August 15 1997 57 (16) 3486-3493;

  
  
• Endocrinology

  Blockade of the Stimulatory Effect of Estrogens, OH-Tamoxifen, OH-Toremifene, Droloxifene, and Raloxifene on Alkaline Phosphatase Activity by the Antiestrogen EM-800 in Human Endometrial Adenocarcinoma Ishikawa Cells

  Jacques Simard, Rocio Sanchez, Donald Poirier, Sylvain Gauthier, Shankar M. Singh, Yves Merand, Alain Belanger, Claude Labrie and Fernand Labrie

  Cancer Res August 15 1997 57 (16) 3494-3497;

  
  
• Experimental therapeutics

  Regulation of Proliferation and Ras Localization in Transformed Cells by Products of Mevalonate Metabolism

  Jennifer A. Cuthbert and Peter E. Lipsky

  Cancer Res August 15 1997 57 (16) 3498-3505;

  
  
• Experimental therapeutics

  Methotrexate Is Excreted into the Bile by Canalicular Multispecific Organic Anion Transporter in Rats

  Masayuki Masuda, Yuji I'izuka, Masayo Yamazaki, Ryuichiro Nishigaki, Yukio Kato, Kayoko Ni'inuma, Hiroshi Suzuki and Yuichi Sugiyama

  Cancer Res August 15 1997 57 (16) 3506-3510;

  
  
• Experimental therapeutics

  Antitumor Activity and Immunotherapeutic Properties of Flt3-Ligand in a Murine Breast Cancer Model

  Keyue Chen, Stephen Braun, Stewart Lyman, Yi Fan, Christie M. Traycoff, Eric A. Wiebke, Jay Gaddy, George Sledge, Hal E. Broxmeyer and Kenneth Cornetta

  Cancer Res August 15 1997 57 (16) 3511-3516;

  
  
• Immunology

  T-Cell Receptor ζ-Chain Expression on Tumor-infiltrating Lymphocytes from Renal Cell Carcinoma

  Gaetano Cardi, John A. Heaney, Alan R. Schned, Dorothy M. Phillips, Mark T. Branda and Marc S. Ernstoff

  Cancer Res August 15 1997 57 (16) 3517-3519;

  
  
• Molecular Biology and Genetics

  Loss of Heterozygosity Analysis in Primary Mammary Tumors and Lung Metastases of MMTV-MTAg and MMTV-neu Transgenic Mice

  Steve R. Ritland, Gerald J. Rowse, Yue Chang and Sandra J. Gendler

  Cancer Res August 15 1997 57 (16) 3520-3525;

  
  
• Molecular Biology and Genetics

  Expression of Neurogenic Basic Helix-Loop-Helix Genes in Primitive Neuroectodermal Tumors

  Robert C. Rostomily, Olivia Bermingham-McDonogh, Mitchel S. Berger, Stephen J. Tapscott, Thomas A. Reh and James M. Olson

  Cancer Res August 15 1997 57 (16) 3526-3531;

  
  
• Molecular Biology and Genetics

  Neurofilament Heavy Chain-like Messenger RNA and Protein Are Present in Benign Prostate and Down-Regulated in Prostatic Carcinoma

  Rosemary L. Schleicher, Stephen B. Hunter, Ming Zhang, Ming Zheng, Wenxiao Tan, Claudiu I. Bandea, Michael T. Fallon, David G. Bostwick and Vijay A. Varma

  Cancer Res August 15 1997 57 (16) 3532-3536;

  
  
• Molecular Biology and Genetics

  Analysis of Expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, Homologues of the Multidrug Resistance-associated Protein Gene (MRP1), in Human Cancer Cell Lines

  Marcel Kool, Marcel de Haas, George L. Scheffer, Rik J. Scheper, Michiel J.T. van Eijk, Jenneke A. Juijn, Frank Baas and Piet Borst

  Cancer Res August 15 1997 57 (16) 3537-3547;

  
  
• Molecular Biology and Genetics

  Isolation of a Candidate Gene, CAB1, for Cholesterol Transport to Mitochondria from the c-ERBB-2 Amplicon by a Modified cDNA Selection Method

  Nobu Akiyama, Hiroki Sasaki, Tomoki Ishizuka, Tatsuya Kishi, Hiromi Sakamoto, Masahiko Onda, Hisamaru Hirai, Yoshio Yazaki, Takashi Sugimura and Masaaki Terada

  Cancer Res August 15 1997 57 (16) 3548-3553;

  
  
• Molecular Biology and Genetics

  RNA Fingerprinting Displays UVB-specific Disruption of Transcriptional Control in Human Melanocytes

  Thomas M. M. Vogt, John Welsh, Wilhelm Stolz, Frank Kullmann, Barbara Jung, Michael Landthaler and Michael McClelland

  Cancer Res August 15 1997 57 (16) 3554-3561;

  
  
• Molecular Biology and Genetics

  Translational Enhancement of mdm2 Oncogene Expression in Human Tumor Cells Containing a Stabilized Wild-Type p53 Protein

  John E. Landers, Suzanne L. Cassel and Donna L. George

  Cancer Res August 15 1997 57 (16) 3562-3568;

  
  
• Molecular Biology and Genetics

  Inhibitors of Both Nuclear Factor-κB and Activator Protein-1 Activation Block the Neoplastic Transformation Response

  Jian-Jian Li, Chandra Westergaard, Paritosh Ghosh and Nancy H. Colburn

  Cancer Res August 15 1997 57 (16) 3569-3576;

  
  
• Tumor Biology

  Purification and Characterization of Human Lung Fibroblast Motility-stimulating Factor for Human Soft Tissue Sarcoma Cells: Identification as an NH₂-terminal Fragment of Human Fibronectin

  Mei Hu, Raphael E. Pollock and Garth L. Nicolson

  Cancer Res August 15 1997 57 (16) 3577-3584;

  
  
• Tumor Biology

  Prevention of Breast Cancer Growth, Invasion, and Metastasis by Antiestrogen Tamoxifen Alone or in Combination with Urokinase Inhibitor B-428

  Rosie Hongmei Xing, Andrew Mazar, Jack Henkin and Shafaat Ahmed Rabbani

  Cancer Res August 15 1997 57 (16) 3585-3593;

  
  
• Tumor Biology

  Inhibition of Prostate Cancer Neovascularization and Growth by Urokinase-Plasminogen Activator Receptor Blockade

  Christopher P. Evans, Fred Elfman, Sareh Parangi, Marion Conn, Gerald Cunha and Marc A. Shuman

  Cancer Res August 15 1997 57 (16) 3594-3599;

  
  
• Tumor Biology

  Resistance to Radiation-induced Apoptosis in Burkitt's Lymphoma Cells Is Associated with Defective Ceramide Signaling

  Julie M. Michael, Martin F. Lavin and Dianne J. Watters

  Cancer Res August 15 1997 57 (16) 3600-3605;

  
  
• Tumor Biology

  Synergy between Transforming Growth Factor α and Hepatitis B Virus Surface Antigen in Hepatocellular Proliferation and Carcinogenesis

  John L. Jakubczak, Francis V. Chisari and Glenn Merlino

  Cancer Res August 15 1997 57 (16) 3606-3611;

  
  
• Tumor Biology

  Tumor Cells with Organ-specific Metastatic Ability Show Distinctive Trafficking in Vivo: Analyses by Positron Emission Tomography and Bioimaging

  Chieko Koike, Manabu Watanabe, Naoto Oku, Hideo Tsukada, Tatsuro Irimura and Shoji Okada

  Cancer Res August 15 1997 57 (16) 3612-3619;

  
  
• Meeting Report

  Molecular Mechanisms for Inflammation-promoted Pathogenesis of Cancer—The Sixteenth International Symposium of the Sapporo Cancer Seminar

  Julie Parsonnet

  Cancer Res August 15 1997 57 (16) 3620-3624;

  
  
• Articles

  Announcements

  Cancer Res August 15 1997 57 (16) 3625-3627;