Table of Contents

Articles

• Advances in Brief

  Characterization of a 4-Mb Region at Chromosome 6q21 Harboring a Replicative Senescence Gene

  Cristina Morelli, Tim Sherratt, Cecilia Trabanelli, Paola Rimessi, Francesca Gualandi, Martin J. Greaves, Massimo Negrini, John M. Boyle and Giuseppe Barbanti-Brodano

  Cancer Res October 1 1997 57 (19) 4153-4157;

  
  
• Advances in Brief

  Loss of Retinoic Acid Receptor β Expression in Breast Cancer and Morphologically Normal Adjacent Tissue but not in the Normal Breast Tissue Distant from the Cancer

  Martin Widschwendter, Jennifer Berger, Günter Daxenbichler, Elisabeth Müller-Holzner, Andreas Widschwendter, Adelcy Mayr, Christian Marth and Alain G. Zeimet

  Cancer Res October 1 1997 57 (19) 4158-4161;

  
  
• Advances in Brief

  Multigenerational Effects of Dietary Fat Carcinogenesis in Mice

  Bruce E. Walker and Lori A. Kurth

  Cancer Res October 1 1997 57 (19) 4162-4163;

  
  
• Advances in Brief

  Genetic Mapping of Lung Cancer Modifier Loci Specifically Affecting Tumor Initiation and Progression

  Giacomo Manenti, Manuela Gariboldi, Antonio Fiorino, Nicola Zanesi, Marco A. Pierotti and Tommaso A. Dragani

  Cancer Res October 1 1997 57 (19) 4164-4166;

  
  
• Advances in Brief

  Detection of Prostate Cancer Cells Circulating in Peripheral Blood by Reverse Transcription-PCR for hKLK2

  Masako Kawakami, Toshikazu Okaneya, Kenichi Furihata, Osamu Nishizawa and Tsutomu Katsuyama

  Cancer Res October 1 1997 57 (19) 4167-4170;

  
  
• Advances in Brief

  Genetic Alterations Accumulate during Cervical Tumorigenesis and Indicate a Common Origin for Multifocal Lesions

  Amy A. Larson, Shu-Yuan Liao, Eric J. Stanbridge, Webster K. Cavenee and Garret M. Hampton

  Cancer Res October 1 1997 57 (19) 4171-4176;

  
  
• Advances in Brief

  Human Mitogen-activated Protein Kinase Kinase 4 as a Candidate Tumor Suppressor

  David H-F. Teng, William L. Perry III, James K. Hogan, Michelle Baumgard, Russell Bell, Simin Berry, Thaylon Davis, David Frank, Cheryl Frye, Thomas Hattier, Rong Hu, Srikanth Jammulapati, Teresa Janecki, Amber Leavitt, Jeffrey T. Mitchell, Ralph Pero, David Sexton, Marianne Schroeder, Pi-Hsia Su, Brad Swedlund, John M. Kyriakis, Joseph Avruch, Paul Bartel, Alexander K. C. Wong, Arnold Oliphant, Alun Thomas, Mark H. Skolnick and Sean V. Tavtigian

  Cancer Res October 1 1997 57 (19) 4177-4182;

  
  
• Advances in Brief

  Somatic Mutations of PTEN in Glioblastoma Multiforme

  Steven I. Wang, Janusz Puc, Jing Li, Jeffrey N. Bruce, Paul Cairns, David Sidransky and Ramon Parsons

  Cancer Res October 1 1997 57 (19) 4183-4186;

  
  
• Advances in Brief

  PTEN Gene Mutations Are Seen in High-Grade but not in Low-Grade Gliomas

  B. K. Ahmed Rasheed, Timothy T. Stenzel, Roger E. McLendon, Ramon Parsons, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner and Sandra H. Bigner

  Cancer Res October 1 1997 57 (19) 4187-4190;

  
  
• Advances in Brief

  Genomic Structure and Genetic Mapping of the Human Neutral Cysteine Protease Bleomycin Hydrolase

  Susana E. Montoya, Robert E. Ferrell and John S. Lazo

  Cancer Res October 1 1997 57 (19) 4191-4195;

  
  
• Advances in Brief

  Pretreatment Prediction of the Chemotherapeutic Response of Human Glioma Cell Cultures Using Nuclear Magnetic Resonance Spectroscopy and Artificial Neural Networks

  Wael El-Deredy, Sally M. Ashmore, Neil M. Branston, John L. Darling, Steven R. Williams and David G. T. Thomas

  Cancer Res October 1 1997 57 (19) 4196-4199;

  
  
• Advances in Brief

  Selection of Human Cervical Epithelial Cells That Possess Reduced Apoptotic Potential to Low-Oxygen Conditions

  Charlotte Y. Kim, Mitchell H. Tsai, Cynthia Osmanian, Thomas G. Graeber, Jong Eun Lee, Rona G. Giffard, Joseph A. DiPaolo, Donna M. Peehl and Amato J. Giaccia

  Cancer Res October 1 1997 57 (19) 4200-4204;

  
  
• Advances in Brief

  Virally Directed Cytosine Deaminase/5-Fluorocytosine Gene Therapy Enhances Radiation Response in Human Cancer Xenografts

  Nader N. Hanna, Helena J. Mauceri, Jeffery D. Wayne, Dennis E. Hallahan, Donald W. Kufe and Ralph R. Weichselbaum

  Cancer Res October 1 1997 57 (19) 4205-4209;

  
  
• Advances in Brief

  Basal Cell Tetrasomy in Low-Grade Cervical Squamous Intraepithelial Lesions Infected with High-Risk Human Papillomaviruses

  Shirley A. Southern, Mark F. Evans and C. Simon Herrington

  Cancer Res October 1 1997 57 (19) 4210-4213;

  
  
• Advances in Brief

  Skin Autografts in Epidermodysplasia Verruciformis: Human Papillomavirus-associated Cutaneous Changes Need Over 20 Years for Malignant Conversion

  Slawomir Majewski and Stefania Jablonska

  Cancer Res October 1 1997 57 (19) 4214-4216;

  
  
• Advances in Brief

  A Region of Allelic Imbalance in 1q31–32 in Primary Breast Cancer Coincides with a Recombination Hot Spot

  Javier Benítez, Ana Osorio, Alicia Barroso, Eva Arranz, Miguel A. Díaz-Guillén, Mercedes Robledo, Santiago Rodríguez de Córdoba and Damián Heine-Suñer

  Cancer Res October 1 1997 57 (19) 4217-4220;

  
  
• Advances in Brief

  Inactivation of Smad4 in Gastric Carcinomas

  Steven M. Powell, Jeffrey C. Harper, Stanley R. Hamilton, C. Rahj Robinson and Oscar W. Cummings

  Cancer Res October 1 1997 57 (19) 4221-4224;

  
  
• Advances in Brief

  Identification of Cellular TSG101 Protein in Multiple Human Breast Cancer Cell Lines

  Qing Zhong, Chi-Fen Chen, Yumay Chen, Phang-Lang Chen and Wen-Hwa Lee

  Cancer Res October 1 1997 57 (19) 4225-4228;

  
  
• Biochemistry and Biophysics

  Oxidation of Cyclophosphamide to 4-Hydroxycyclophosphamide and Deschloroethylcyclophosphamide in Human Liver Microsomes

  Song Ren, Ji-Sun Yang, Thomas F. Kalhorn and John T. Slattery

  Cancer Res October 1 1997 57 (19) 4229-4235;

  
  
• Biochemistry and Biophysics

  Nucleocytoplasmic Functionality of Metallothionein

  Elizabeth S. Woo and John S. Lazo

  Cancer Res October 1 1997 57 (19) 4236-4241;

  
  
• Biochemistry and Biophysics

  Oxythiamine and Dehydroepiandrosterone Inhibit the Nonoxidative Synthesis of Ribose and Tumor Cell Proliferation

  Laszlo G. Boros, Joaquim Puigjaner, Marta Cascante, Wai-Nang Paul Lee, James L. Brandes, Sara Bassilian, Fouza I. Yusuf, Robert D. Williams, Pete Muscarella, W. Scott Melvin and William J. Schirmer

  Cancer Res October 1 1997 57 (19) 4242-4248;

  
  
• Biochemistry and Biophysics

  Increased α2,6 Sialylation of N-Glycans in a Transgenic Mouse Model of Hepatocellular Carcinoma

  Dominique Pousset, Véronique Piller, Nicole Bureaud, Michel Monsigny and Friedrich Piller

  Cancer Res October 1 1997 57 (19) 4249-4256;

  
  
• Carcinogenesis

  Protection Conferred by Selenium Deficiency against Aflatoxin B₁ in the Rat Is Associated with the Hepatic Expression of an Aldo-Keto Reductase and a Glutathione S-Transferase Subunit That Metabolize the Mycotoxin

  Ronald McLeod, Elizabeth M. Ellis, John R. Arthur, Gordon E. Neal, David J. Judah, Margaret M. Manson and John D. Hayes

  Cancer Res October 1 1997 57 (19) 4257-4266;

  
  
• Carcinogenesis

  Sulindac Causes Rapid Regression of Preexisting Tumors in Min/+ Mice Independent of Prostaglandin Biosynthesis

  Chun-Hung Chiu, Michael F. McEntee and Jay Whelan

  Cancer Res October 1 1997 57 (19) 4267-4273;

  
  
• Carcinogenesis

  Earlier Onset of Melanotroph Carcinogenesis in Mice with Inherited Mutant Paternal Allele of the Retinoblastoma Gene

  Alexander Yu. Nikitin, Daniel J. Riley and Wen-Hwa Lee

  Cancer Res October 1 1997 57 (19) 4274-4278;

  
  
• Experimental Therapeutics

  In Vivo Selective Gene Expression and Therapy Mediated by Adenoviral Vectors for Human Carcinoembryonic Antigen-producing Gastric Carcinoma

  Keng-Hsin Lan, Fumihiko Kanai, Yasushi Shiratori, Makoto Ohashi, Torao Tanaka, Takehito Okudaira, Yoko Yoshida, Hirofumi Hamada and Masao Omata

  Cancer Res October 1 1997 57 (19) 4279-4284;

  
  
• Experimental Therapeutics

  Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents

  Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy G. Myers, Saijun Fan, Masato Mutoh, Dominic A. Scudiero, Ann Monks, Edward A. Sausville, John N. Weinstein, Stephen Friend, Albert J. Fornace Jr. and Kurt W. Kohn

  Cancer Res October 1 1997 57 (19) 4285-4300;

  
  
• Experimental Therapeutics

  Role of Topoisomerase IIβ in the Resistance of 9-OH-ellipticine-resistant Chinese Hamster Fibroblasts to Topoisomerase II Inhibitors

  Sophie Dereuddre, Charlotte Delaporte and Alain Jacquemin-Sablon

  Cancer Res October 1 1997 57 (19) 4301-4308;

  
  
• Experimental Therapeutics

  Growth Inhibitory Effects of Sodium Phenylacetate (NSC 3039) on Ovarian Carcinoma Cells in Vitro

  Gabriella Ferrandina, Bohuslav Melichar, Amy Loercher, Claire F. Verschraegen, Andrzej P. Kudelka, Creighton L. Edwards, Giovanni Scambia, John J. Kavanagh, James L. Abbruzzese and Ralph S. Freedman

  Cancer Res October 1 1997 57 (19) 4309-4315;

  
  
• Experimental Therapeutics

  R-Flurbiprofen Chemoprevention and Treatment of Intestinal Adenomas in the APC^Min/+ Mouse Model: Implications for Prophylaxis and Treatment of Colon Cancer

  William J. Wechter, Darko Kantoci, E. David Murray Jr., David D. Quiggle, Douglas D. Leipold, Karina M. Gibson and John D. McCracken

  Cancer Res October 1 1997 57 (19) 4316-4324;

  
  
• Experimental Therapeutics

  Molecular Chemotherapy Combined with Radiation Therapy Enhances Killing of Cholangiocarcinoma Cells in Vitro and in Vivo

  Lee C. Pederson, Donald J. Buchsbaum, Selwyn M. Vickers, Sreekanth R. Kancharla, Matthew S. Mayo, David T. Curiel and Murray A. Stackhouse

  Cancer Res October 1 1997 57 (19) 4325-4332;

  
  
• Experimental Therapeutics

  Intratumoral Delivery of Boronated Epidermal Growth Factor for Neutron Capture Therapy of Brain Tumors

  Weilian Yang, Rolf F. Barth, Dianne M. Adams and Albert H. Soloway

  Cancer Res October 1 1997 57 (19) 4333-4339;

  
  
• Experimental Therapeutics

  Decreasing the Apoptotic Threshold of Tumor Cells through Protein Kinase C Inhibition and Sphingomyelinase Activation Increases Tumor Killing by Ionizing Radiation

  Steven J. Chmura, Helena J. Mauceri, Sunil Advani, Ruth Heimann, Michael A. Beckett, Edwardine Nodzenski, Jose Quintans, Donald W. Kufe and Ralph R. Weichselbaum

  Cancer Res October 1 1997 57 (19) 4340-4347;

  
  
• Immunology

  Synthetic Peptides Derived from the Melanocyte-stimulating Hormone Receptor MC1R Can Stimulate HLA-A2-restricted Cytotoxic T Lymphocytes That Recognize Naturally Processed Peptides on Human Melanoma Cells

  Flavio Salazar-Onfray, Tsutomu Nakazawa, Vijay Chhajlani, Max Petersson, Klas Kärre, Giuseppe Masucci, Esteban Celis, Alessandro Sette, Scott Southwood, Ettore Appella and Rolf Kiessling

  Cancer Res October 1 1997 57 (19) 4348-4355;

  
  
• Molecular Biology and Genetics

  Developmental Exposure to Diethylstilbestrol Elicits Demethylation of Estrogen-responsive Lactoferrin Gene in Mouse Uterus

  Shuanfang Li, Kimberly A. Washburn, Rick Moore, Tomohide Uno, Christina Teng, Retha R. Newbold, John A. McLachlan and Masahiko Negishi

  Cancer Res October 1 1997 57 (19) 4356-4359;

  
  
• Molecular Biology and Genetics

  Mapping of DNA Amplifications at 15 Chromosomal Localizations in 1875 Breast Tumors: Definition of Phenotypic Groups

  Frank Courjal, Marguerite Cuny, Joelle Simony-Lafontaine, Geneviève Louason, Paul Speiser, Robert Zeillinger, Carmen Rodriguez and Charles Theillet

  Cancer Res October 1 1997 57 (19) 4360-4367;

  
  
• Molecular Biology and Genetics

  Comparative Genomic Hybridization Analysis of Breast Tumors with Predetermined Profiles of DNA Amplification

  Frank Courjal and Charles Theillet

  Cancer Res October 1 1997 57 (19) 4368-4377;

  
  
• Molecular Biology and Genetics

  Polychlorinated Biphenyls and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induce Intrachromosomal Recombination in Vitro and in Vivo

  Robert H. Schiestl, Jiri Aubrecht, Wendy Y. Yap, Sridevi Kandikonda and Samy Sidhom

  Cancer Res October 1 1997 57 (19) 4378-4383;

  
  
• Molecular Biology and Genetics

  A Lack of Radiation-induced Ornithine Decarboxylase Activity Prevents Enhanced Reactivation of Herpes Simplex Virus and Is Linked to Non-Cancer Proneness in Xeroderma Pigmentosum Patients

  Carrol Terleth, Theo van Laar, Ron Schouten, Harry van Steeg, Hennie Hodemaekers, Thera Wormhoudt, Paulien D. M. Cornelissen-Steijger, Peter J. Abrahams and Alex J. van der Eb

  Cancer Res October 1 1997 57 (19) 4384-4392;

  
  
• Molecular Biology and Genetics

  Mutation Frequency and Spectrum in Lymphocytes of Small Cell Lung Cancer Patients Receiving Etoposide Chemotherapy

  Larissa Karnaoukhova, Joyce Moffat, Heidi Martins and Barry Glickman

  Cancer Res October 1 1997 57 (19) 4393-4407;

  
  
• Molecular Biology and Genetics

  The Absolute Number of Trans-Rearrangements between the TCRG and TCRB Loci Is Predictive of Lymphoma Risk: A Severe Combined Immune Deficiency (SCID) Murine Model

  Florigio Lista, Virginia Bertness, Cynthia J. Guidos, Jayne S. Danska and Ilan R. Kirsch

  Cancer Res October 1 1997 57 (19) 4408-4413;

  
  
• Molecular Biology and Genetics

  Inhibition of Tumor Promoter-induced Activator Protein 1 Activation and Cell Transformation by Tea Polyphenols, (-)-Epigallocatechin Gallate, and Theaflavins

  Zigang Dong, Wei-ya Ma, Chuanshu Huang and Chung S. Yang

  Cancer Res October 1 1997 57 (19) 4414-4419;

  
  
• Molecular Biology and Genetics

  Frameshift Somatic Mutations in Gastrointestinal Cancer of the Microsatellite Mutator Phenotype

  Hiroyuki Yamamoto, Hisako Sawai and Manuel Perucho

  Cancer Res October 1 1997 57 (19) 4420-4426;

  
  
• Tumor Biology

  Immunolocalization and Messenger RNA Expression of Bone Morphogenetic Protein-6 in Human Benign and Malignant Prostatic Tissue

  Freddie C. Hamdy, Pernillle Autzen, Mary C. Robinson, C. H. Wilson Horne, David E. Neal and Craig N. Robson

  Cancer Res October 1 1997 57 (19) 4427-4431;

  
  
• Tumor Biology

  In Vivo Induction of Murine Cytokine Production by Carcinoembryonic Antigen

  Kirsten H. Edmiston, Aniruddha Gangopadhyay, Yutaka Shoji, Alex P. Nachman, Peter Thomas and J. Milburn Jessup

  Cancer Res October 1 1997 57 (19) 4432-4436;

  
  
• Meeting Report

  Eighth Annual Pezcoller Symposium: Genomic Instability and Immortality in Cancer

  Enrico Mihich and Leland Hartwell

  Cancer Res October 1 1997 57 (19) 4437-4441;

  
  
• Articles

  Announcements

  Cancer Res October 1 1997 57 (19) 4442-4444;