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Advances in Brief

The Prostate: A Target for Carcinogenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Derived from Cooked Foods

Tomoyuki Shirai, Masashi Sano, Seiko Tamano, Satoru Takahashi, Masao Hirose, Mitsuru Futakuchi, Ryohei Hasegawa, Katsumi Imaida, Ken-ichiro Matsumoto, Keiji Wakabayashi, Takashi Sugimura and Nobuyuki Ito
Tomoyuki Shirai
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Masashi Sano
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Seiko Tamano
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Satoru Takahashi
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Masao Hirose
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Mitsuru Futakuchi
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Ryohei Hasegawa
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Katsumi Imaida
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Ken-ichiro Matsumoto
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Keiji Wakabayashi
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Takashi Sugimura
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Nobuyuki Ito
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DOI:  Published January 1997
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Abstract

Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), at a dose of 400 ppm in the diet for 52 weeks were histopathologically evaluated and found to contain prostate carcinomas limited to the ventral lobe in 18 of 27 cases. Atypical hyperplasias were also detected in the ventral and anterior prostate as well as the seminal vesicles. 32P-Postlabeling analysis of DNA demonstrated that PhIP-DNA adducts are produced in all lobes of the prostate of rats receiving PhIP. The findings indicate that PhIP is carcinogenic to rat prostate in addition to the previously demonstrated targeting of the colon and mammary glands, providing evidence of a possible role of PhIP in human prostate carcinogenesis and highlighting the potential importance of PhIP for man.

Footnotes

  • ↵1 Supported in part by grants-in-aid for cancer research from the Ministry of Education, Science, Sports and Culture and the Ministry of Health and Welfare of Japan, a grant-in-aid from the Ministry of Health and Welfare for the Second-Term Comprehensive 10-Year Strategy for Cancer Control, Japan, and a grant from the Society for Promotion of Toxicological Pathology of Nagoya, Japan.

  • ↵2 To whom requests for reprints should be addressed.

  • Received October 7, 1996.
  • Accepted December 3, 1996.
  • ©1997 American Association for Cancer Research.
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January 1997
Volume 57, Issue 2
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The Prostate: A Target for Carcinogenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Derived from Cooked Foods
Tomoyuki Shirai, Masashi Sano, Seiko Tamano, Satoru Takahashi, Masao Hirose, Mitsuru Futakuchi, Ryohei Hasegawa, Katsumi Imaida, Ken-ichiro Matsumoto, Keiji Wakabayashi, Takashi Sugimura and Nobuyuki Ito
Cancer Res January 15 1997 (57) (2) 195-198;

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The Prostate: A Target for Carcinogenicity of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Derived from Cooked Foods
Tomoyuki Shirai, Masashi Sano, Seiko Tamano, Satoru Takahashi, Masao Hirose, Mitsuru Futakuchi, Ryohei Hasegawa, Katsumi Imaida, Ken-ichiro Matsumoto, Keiji Wakabayashi, Takashi Sugimura and Nobuyuki Ito
Cancer Res January 15 1997 (57) (2) 195-198;
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