Table of Contents

Articles

• Advances in Brief

  Dietary Restriction Reduces Insulin-like Growth Factor I Levels, Which Modulates Apoptosis, Cell Proliferation, and Tumor Progression in p53-deficient Mice

  Sandra E. Dunn, Frank W. Kari, John French, Joel R. Leininger, Greg Travlos, Ralph Wilson and J. Carl Barrett

  Cancer Res November 1 1997 57 (21) 4667-4672;

  
  
• Advances in Brief

  Hyperlipidemia Enhancement of Renal Preneoplasia but not Tumor Formation Is Due to Elevated Apoptosis in the Eker Rat

  Shunji Miki, Yoshitsugu Miki, Hiroaki Mitani, Bunzo Sato, Masahiro Yamamoto and Okio Hino

  Cancer Res November 1 1997 57 (21) 4673-4676;

  
  
• Advances in Brief

  Trichoepitheliomas Contain Somatic Mutations in the Overexpressed PTCH Gene: Support for a Gatekeeper Mechanism in Skin Tumorigenesis

  Igor Vŏrechovský, Anne Birgitte Undén, Bengt Sandstedt, Rune Toftgård and Mona Ståhle-Bäckdahl

  Cancer Res November 1 1997 57 (21) 4677-4681;

  
  
• Advances in Brief

  Somatic Mutations of the MEN1 Tumor Suppressor Gene in Sporadic Gastrinomas and Insulinomas

  Zhengping Zhuang, Alexander O. Vortmeyer, Svetlana Pack, Steve Huang, Thu A. Pham, Chaoyu Wang, Won-Sang Park, Sunita K. Agarwal, Larisa V. Debelenko, MaryBeth Kester, Siradanahalli C. Guru, Pachiappan Manickam, Shodimu-Emmanuel Olufemi, Fang Yu, Christina Heppner, Judy S. Crabtree, Monica C. Skarulis, David J. Venzon, Michael R. Emmert-Buck, Allen M. Spiegel, Settara C. Chandrasekharappa, Francis S. Collins, A. Lee Burns, Stephen J. Marx, Robert T. Jensen, Lance A. Liotta and Irina A. Lubensky

  Cancer Res November 1 1997 57 (21) 4682-4686;

  
  
• Advances in Brief

  Androgen-independent Prostate Cancer Progression in the TRAMP Model

  Jeffrey R. Gingrich, Roberto J. Barrios, Michael W. Kattan, Hyun S. Nahm, Milton J. Finegold and Norman M. Greenberg

  Cancer Res November 1 1997 57 (21) 4687-4691;

  
  
• Advances in Brief

  Loss of FHIT Expression in Cervical Carcinoma Cell Lines and Primary Tumors

  David L. Greenspan, Denise C. Connolly, Rong Wu, Rachel Y. Lei, Joshua T. C. Vogelstein, Young-Tak Kim, Jung Eun Mok, Nubia Muñoz, F. Xavier Bosch, Keerti Shah and Kathleen R. Cho

  Cancer Res November 1 1997 57 (21) 4692-4698;

  
  
• Advances in Brief

  A Precise Interchromosomal Reciprocal Exchange between Hot Spots for Cleavable Complex Formation by Topoisomerase II in Amsacrine-treated Chinese Hamster Ovary Cells

  Rui-Hua Zhou, Peng Wang, Ying Zou, Colleen K. Jackson-Cook and Lawrence F. Povirk

  Cancer Res November 1 1997 57 (21) 4699-4702;

  
  
• Advances in Brief

  Loss of p21^Waf1/Cip1 Sensitizes Tumors to Radiation by an Apoptosis-independent Mechanism

  Bradly G. Wouters, Amato J. Giaccia, Nicholas C. Denko and J. Martin Brown

  Cancer Res November 1 1997 57 (21) 4703-4706;

  
  
• Advances in Brief

  Early Age at Diagnosis in Families Providing Evidence of Linkage to the Hereditary Prostate Cancer Locus (HPC1) on Chromosome 1

  Henrik Grönberg, Jianfeng Xu, Jeffrey R. Smith, John D. Carpten, Sarah D. Isaacs, Diha Freije, G. Steven Bova, Patrick C. Walsh, Francis S. Collins, Jeffrey M. Trent, Deborah A. Meyers and William B. Isaacs

  Cancer Res November 1 1997 57 (21) 4707-4709;

  
  
• Advances in Brief

  Somatic Deletions and Mutations in the Cowden Disease Gene, PTEN, in Sporadic Thyroid Tumors

  Patricia L. M. Dahia, Debbie J. Marsh, Zimu Zheng, Jan Zedenius, Paul Komminoth, Tony Frisk, Goran Wallin, Ramon Parsons, Michel Longy, Catharina Larsson and Charis Eng

  Cancer Res November 1 1997 57 (21) 4710-4713;

  
  
• Advances in Brief

  Activated Ki-ras Enhances Sensitivity of Ceramide-induced Apoptosis without c-Jun NH₂-Terminal Kinase/Stress-activated Protein Kinase or Extracellular Signal-regulated Kinase Activation in Human Colon Cancer Cells

  Mariko Ohmori, Senji Shirasawa, Masanori Furuse, Koji Okumura and Takehiko Sasazuki

  Cancer Res November 1 1997 57 (21) 4714-4717;

  
  
• Advances in Brief

  Association of Human T-Cell Leukemia Virus and Myelodysplastic Syndrome in a Central European Population

  Heidrun Karlic, Michaela Möstl, Hermann Mucke, Borislava Pavlova, Michael Pfeilstöcker and Renate Heinz

  Cancer Res November 1 1997 57 (21) 4718-4721;

  
  
• Advances in Brief

  Adenovirus-Mediated Overexpression of the Transcription Factor E2F-1 Induces Apoptosis in Human Breast and Ovarian Carcinoma Cell Lines and Does Not Require p53

  Kelly K. Hunt, Jiong Deng, Ta-Jen Liu, Marcia Wilson-Heiner, Stephen G. Swisher, Gary Clayman and Mien-Chie Hung

  Cancer Res November 1 1997 57 (21) 4722-4726;

  
  
• Advances in Brief

  Sunlight Induces Pyrimidine Dimers Preferentially at 5-Methylcytosine Bases

  Stella Tommasi, Mikhail F. Denissenko and Gerd P. Pfeifer

  Cancer Res November 1 1997 57 (21) 4727-4730;

  
  
• Advances in Brief

  Patched (ptch)-associated Preferential Expression of Smoothened (smoh) in Human Basal Cell Carcinoma of the Skin

  Mireille Kallassy, Rune Toftgård, Masato Ueda, Keiko Nakazawa, Igor Vŏrechovský, Hiroshi Yamasaki and Hisayoshi Nakazawa

  Cancer Res November 1 1997 57 (21) 4731-4735;

  
  
• Advances in Brief

  PTEN/MMAC1 Mutations in Endometrial Cancers

  John I. Risinger, A. Kate Hayes, Andrew Berchuck and J. Carl Barrett

  Cancer Res November 1 1997 57 (21) 4736-4738;

  
  
• Advances in Brief

  Microsatellite Instability Analysis: A Multicenter Study for Reliability and Quality Control

  Tina Bocker, Johannes Diermann, Waltraut Friedl, Johannes Gebert, Elke Holinski-Feder, Judith Karner-Hanusch, Magnus von Knebel-Doeberitz, Konrad Koelble, Gabriela Moeslein, Hans-Konrad Schackert, Hans-Christian Wirtz, Richard Fishel and Josef Rüschoff

  Cancer Res November 1 1997 57 (21) 4739-4743;

  
  
• Biochemistry and Biophysics

  Expression of Three UDP-N-acetyl-α-d-galactosamine:Polypeptide GalNAc N-Acetylagalactosaminyltransferases in Adenocarcinoma Cell Lines

  Marie E. Sutherlin, Isao Nishimori, Thomas Caffrey, Eric P. Bennett, Helle Hassan, Ulla Mandel, David Mack, Takeshi Iwamura, Henrik Clausen and Michael A. Hollingsworth

  Cancer Res November 1 1997 57 (21) 4744-4748;

  
  
• Carcinogenesis

  Diagnostic Microsatellite Instability: Definition and Correlation with Mismatch Repair Protein Expression

  Wolfgang Dietmaier, Sabine Wallinger, Tina Bocker, Frank Kullmann, Richard Fishel and Josef Rüschoff

  Cancer Res November 1 1997 57 (21) 4749-4756;

  
  
• Carcinogenesis

  Inhibition of Human Cytochrome P450-catalyzed Oxidations of Xenobiotics and Procarcinogens by Synthetic Organoselenium Compounds

  Tsutomu Shimada, Karam El-Bayoumy, Pramod Upadhyaya, Thomas R. Sutter, F. Peter Guengerich and Hiroshi Yamazaki

  Cancer Res November 1 1997 57 (21) 4757-4764;

  
  
• Carcinogenesis

  Cyclin D1 Overexpression in Rat Two-Stage Bladder Carcinogenesis and Its Relationship with Oncogenes, Tumor Suppressor Genes, and Cell Proliferation

  Chyi Chia R. Lee, Shinji Yamamoto, Hideki Wanibuchi, Seiji Wada, Kazunobu Sugimura, Taketoshi Kishimoto and Soji Fukushima

  Cancer Res November 1 1997 57 (21) 4765-4776;

  
  
• Clinical Investigations

  Angiogenesis of Uterine Cervical Carcinoma: Characterization by Pharmacokinetic Magnetic Resonance Parameters and Histological Microvessel Density with Correlation to Lymphatic Involvement

  Hans Hawighorst, Paul G. Knapstein, Wolfgang Weikel, Michael V. Knopp, Ivan Zuna, Almuth Knof, Gunnar Brix, Uwe Schaeffer, Claudia Wilkens, Stefan O. Schoenberg, Marco Essig, Peter Vaupel and Gerhard van Kaick

  Cancer Res November 1 1997 57 (21) 4777-4786;

  
  
• Epidemiology and Prevention

  Associations of Sedentary Lifestyle, Obesity, Smoking, Alcohol Use, and Diabetes with the Risk of Colorectal Cancer

  Loïc Le Marchand, Lynne R. Wilkens, Laurence N. Kolonel, Jean H. Hankin and Li-Ching Lyu

  Cancer Res November 1 1997 57 (21) 4787-4794;

  
  
• Experimental Therapeutics

  Selective Tumor Apoptosis by MF13, l-Prolyl-l-m-[bis(chloroethyl)amino]-phenylalanyl-l-norvaline Ethyl Ester, a New Sarcolysin Containing Tripeptide

  John Roboz, Jiandong Jiang, James F. Holland and J. George Bekesi

  Cancer Res November 1 1997 57 (21) 4795-4802;

  
  
• Experimental Therapeutics

  Potent Antitumor Activity of a Novel Nucleoside Analogue, BCH-4556 (β-l-Dioxolane-cytidine), in Human Renal Cell Carcinoma Xenograft Tumor Models

  Salam A. Kadhim, Terry L. Bowlin, William R. Waud, Elyzabeth G. Angers, Lucie Bibeau, Jean-Marc DeMuys, Krzysztof Bednarski, Alex Cimpoia and Giorgio Attardo

  Cancer Res November 1 1997 57 (21) 4803-4810;

  
  
• Experimental Therapeutics

  Cellular Pharmacokinetics and Cytotoxicity of Camptothecin and Topotecan at Normal and Acidic pH

  Attia Gabr, Annemieke Kuin, Marjanka Aalders, Hoda El-Gawly and Lou A. Smets

  Cancer Res November 1 1997 57 (21) 4811-4816;

  
  
• Experimental Therapeutics

  O⁶-Methylguanine-DNA Methyltransferase (MGMT) Transfectants of a 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive Colon Cancer Cell Line Selectively Repopulate Heterogeneous MGMT⁺/MGMT^- Xenografts after BCNU and O⁶-Benzylguanine plus BCNU

  Weldon P. Phillips Jr., James K. V. Willson, Sanford D. Markowitz, Elizabeth Zborowska, Nasir H. Zaidi, Lili Liu, Nahida H. Gordon and Stanton L. Gerson

  Cancer Res November 1 1997 57 (21) 4817-4823;

  
  
• Experimental Therapeutics

  Systemic Therapy with 3BIT, a Triple Combination Cocktail of Anti-CD19, -CD22, and -CD38-Saporin Immunotoxins, Is Curative of Human B-Cell Lymphoma in Severe Combined Immunodeficient Mice

  David J. Flavell, Armorel Noss, Karen A. F. Pulford, Noel Ling and Sopsamorn U. Flavell

  Cancer Res November 1 1997 57 (21) 4824-4829;

  
  
• Experimental Therapeutics

  Potentiation of Cytochrome P450/Cyclophosphamide-based Cancer Gene Therapy by Coexpression of the P450 Reductase Gene

  Ling Chen, Li J. Yu and David J. Waxm

  Cancer Res November 1 1997 57 (21) 4830-4837;

  
  
• Experimental Therapeutics

  Induction of Apoptosis and Cell Cycle Arrest by CP-358,774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase

  James D. Moyer, Elsa G. Barbacci, Kenneth K. Iwata, Lee Arnold, Bruce Boman, Ann Cunningham, Catherine DiOrio, Jonathan Doty, Michael J. Morin, Mikel P. Moyer, Mark Neveu, Vincent A. Pollack, Leslie R. Pustilnik, Margaret M. Reynolds, Don Sloan, April Theleman and Penny Miller

  Cancer Res November 1 1997 57 (21) 4838-4848;

  
  
• Immunology

  Monocyte Chemoattractant Protein Inhibits the Generation of Tumor-reactive T Cells

  Liaomin Peng, Suyu Shu and John C. Krauss

  Cancer Res November 1 1997 57 (21) 4849-4854;

  
  
• Immunology

  Human Papillomavirus-specific Cytotoxic T Lymphocytes in Patients with Cervical Intraepithelial Neoplasia Grade III

  Mercy Nimako, Alison N. Fiander, Gavin W. G. Wilkinson, Leszek K. Borysiewicz and Stephen Man

  Cancer Res November 1 1997 57 (21) 4855-4861;

  
  
• Molecular Biology and Genetics

  Persistent Clonal Proliferation of Human T-lymphotropic Virus Type I-infected Cells in Vivo

  Ken-ichiro Etoh, Sadahiro Tamiya, Kazunari Yamaguchi, Akihiko Okayama, Hirohito Tsubouchi, Toru Ideta, Nancy Mueller, Kiyoshi Takatsuki and Masao Matsuoka

  Cancer Res November 1 1997 57 (21) 4862-4867;

  
  
• Molecular Biology and Genetics

  CDKN2A/p16 Is Inactivated in Most Melanoma Cell Lines

  Marina Castellano, Pamela M. Pollock, Marilyn K. Walters, Louise E. Sparrow, Louise M. Down, Brian G. Gabrielli, Peter G. Parsons and Nicholas K. Hayward

  Cancer Res November 1 1997 57 (21) 4868-4875;

  
  
• Molecular Biology and Genetics

  Ribonucleotide Reductase R2 Gene Expression and Changes in Drug Sensitivity and Genome Stability

  Aiping Huang, Huizhou Fan, William R. Taylor and Jim A. Wright

  Cancer Res November 1 1997 57 (21) 4876-4881;

  
  
• Molecular Biology and Genetics

  Regulation of Collagenase-3 Expression in Human Breast Carcinomas Is Mediated by Stromal-Epithelial Cell Interactions

  José A. Uría, Mona Stahle-Bäckdahl, Motoharu Seiki, Antonio Fueyo and Carlos López-Otín

  Cancer Res November 1 1997 57 (21) 4882-4888;

  
  
• Tumor Biology

  CD44 Expression Is Aberrant in Benign Schwann Cell Tumors Possessing Mutations in the Neurofibromatosis Type 2, but not Type 1, Gene

  Larry Sherman, Lee B. Jacoby, Johannes Lampe, Patricia Pelton, Adriano Aguzzi, Peter Herrlich and Helmut Ponta

  Cancer Res November 1 1997 57 (21) 4889-4897;

  
  
• Tumor Biology

  Establishment of Human Peripheral Lung Epithelial Cell Lines (HPL1) Retaining Differentiated Characteristics and Responsiveness to Epidermal Growth Factor, Hepatocyte Growth Factor, and Transforming Growth Factor β1

  Akira Masuda, Masashi Kondo, Toshiko Saito, Yasushi Yatabe, Tomoko Kobayashi, Mitsumasa Okamoto, Motokazu Suyama, Toshitada Takahashi and Takashi Takahashi

  Cancer Res November 1 1997 57 (21) 4898-4904;

  
  
• Tumor Biology

  MXI1, a Putative Tumor Suppressor Gene, Suppresses Growth of Human Glioblastoma Cells

  Daniel S. Wechsler, Candace A. Shelly, Christy A. Petroff and Chi V. Dang

  Cancer Res November 1 1997 57 (21) 4905-4912;

  
  
• Tumor Biology

  DNA Hypermethylation at the D17S5 Locus in Non-Small Cell Lung Cancers: Its Association with Smoking History

  Keisuke Eguchi, Yae Kanai, Koichi Kobayashi and Setsuo Hirohashi

  Cancer Res November 1 1997 57 (21) 4913-4915;

  
  
• Tumor Biology

  Role of Intracellular Redox Status in Apoptosis Induction of Human T-Cell Leukemia Virus Type I-infected Lymphocytes by 13-cis-Retinoic Acid

  Keizo Furuke, Tetsuro Sasada, Yasuyo Ueda-Taniguchi, Akira Yamauchi, Takashi Inamoto, Yoshio Yamaoka, Hiroshi Masutani and Junji Yodoi

  Cancer Res November 1 1997 57 (21) 4916-4923;

  
  
• Tumor Biology

  Specific and Efficient Peptide Substrates for Assaying the Proteolytic Activity of Prostate-specific Antigen

  Samuel R. Denmeade, Wei Lou, Janita Lövgren, Johan Malm, Hans Lilja and John T. Isaacs

  Cancer Res November 1 1997 57 (21) 4924-4930;

  
  
• Tumor Biology

  Differential Effects of Synthetic Nuclear Retinoid Receptor-selective Retinoids on the Growth of Human Non-Small Cell Lung Carcinoma Cells

  Shi-Yong Sun, Ping Yue, Marcia I. Dawson, Braham Shroot, Serge Michel, William W. Lamph, Richard A. Heyman, Min Teng, Roshantha A. S. Chandraratna, Koichi Shudo, Waun K. Hong and Reuben Lotan

  Cancer Res November 1 1997 57 (21) 4931-4939;

  
  
• Tumor Biology

  B Lymphocytes from Patients with Chronic Lymphoproliferative Disorders Are Equipped with Different Costimulatory Molecules

  Livio Trentin, Renato Zambello, Rosaria Sancetta, Monica Facco, Andrea Cerutti, Alessandra Perin, Marta Siviero, Umberto Basso, Michela Bortolin, Fausto Adami, Carlo Agostini and Gianpietro Semenzato

  Cancer Res November 1 1997 57 (21) 4940-4947;

  
  
• Tumor Biology

  Elimination of Established Murine Colon Carcinoma Metastases by Antibody- Interleukin 2 Fusion Protein Therapy

  Rong Xiang, Holger N. Lode, Carrie S. Dolman, Torsten Dreier, Nissi M. Varki, Xiuqi Qian, Kin-Ming Lo, Yan Lan, Michael Super, Stephen D. Gillies and Ralph A. Reisfeld

  Cancer Res November 1 1997 57 (21) 4948-4955;

  
  
• Tumor Biology

  Betulinic Acid Triggers CD95 (APO-1/Fas)- and p53-independent Apoptosis via Activation of Caspases in Neuroectodermal Tumors

  Simone Fulda, Claudia Friesen, Marek Los, Carsten Scaffidi, Walter Mier, Mary Benedict, Gabriel Nuñez, Peter H. Krammer, Marcus E. Peter and Klaus-Michael Debatin

  Cancer Res November 1 1997 57 (21) 4956-4964;

  
  
• Tumor Biology

  Mechanisms of the Regulation of Thioredoxin Reductase Activity in Cancer Cells by the Chemopreventive Agent Selenium

  Alfred Gallegos, Margareta Berggren, John R. Gasdaska and Garth Powis

  Cancer Res November 1 1997 57 (21) 4965-4970;

  
  
• Articles

  Announcements

  Cancer Res November 1 1997 57 (21) 4971-4973;

  
  
• Articles

  Errata

  Cancer Res November 1 1997 57 (21) 4973-4973;

  
  
• Articles

  Employment Register of the American for Cancer Research

  Cancer Res November 1 1997 57 (21) 4974-4984;