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Advances in Brief

Malignant Transformation of Human Prostate Epithelial Cells by N-nitroso-N-methylurea

Johng S. Rhim, Sunji Jin, Mira Jung, Peter J. Thraves, Michael R. Kuettel, Mukta M. Webber and Bharati Hukku
Johng S. Rhim
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Sunji Jin
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Mira Jung
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Peter J. Thraves
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Michael R. Kuettel
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Mukta M. Webber
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Bharati Hukku
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DOI:  Published February 1997
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Abstract

We report the malignant transformation of adult human prostate epithelial cells after multiple exposures to the chemical carcinogen N-nitroso-N-methylurea. Such transformants showed morphological alterations and anchorage-independent growth in soft agar and induced carcinomas when transplanted into nude mice. No p53 or ras mutations were observed. Stepwise chromosomal changes in the progression to tumorigenicity were observed. Loss of the p arms of chromosome 8 (p10>pter) and chromosome 10 (p10>pter) and gain of the q arm of chromosome 8 (q10>qter) were only observed in the tumor outgrows. These findings provide the first evidence of malignant transformation of human prostate epithelial cells exposed to a chemical carcinogen.

Footnotes

  • ↵1 To whom requests for reprints should be addressed. Phone: (301) 846-1592; Fax: (301) 846-6863.

  • Received November 1, 1996.
  • Accepted January 4, 1997.
  • ©1997 American Association for Cancer Research.
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February 1997
Volume 57, Issue 4
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Malignant Transformation of Human Prostate Epithelial Cells by N-nitroso-N-methylurea
Johng S. Rhim, Sunji Jin, Mira Jung, Peter J. Thraves, Michael R. Kuettel, Mukta M. Webber and Bharati Hukku
Cancer Res February 15 1997 (57) (4) 576-580;

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Malignant Transformation of Human Prostate Epithelial Cells by N-nitroso-N-methylurea
Johng S. Rhim, Sunji Jin, Mira Jung, Peter J. Thraves, Michael R. Kuettel, Mukta M. Webber and Bharati Hukku
Cancer Res February 15 1997 (57) (4) 576-580;
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