Table of Contents

Articles

• Advances in Brief

  Molecular Genetic Characterization of BRCA1- and BRCA2-Linked Hereditary Ovarian Cancers

  Esther Rhei, Faina Bogomolniy, Mark G. Federici, Diane L. Maresco, Kenneth Offit, Mark E. Robson, Patricia E. Saigo and Jeff Boyd

  Cancer Res August 1 1998 58 (15) 3193-3196;

  
  
• Advances in Brief

  Altered Estrogen Receptor α and β Messenger RNA Expression during Human Breast Tumorigenesis

  Etienne Leygue, Helmut Dotzlaw, Peter H. Watson and Leigh C. Murphy

  Cancer Res August 1 1998 58 (15) 3197-3201;

  
  
• Advances in Brief

  “Loop” Domain Is Necessary for Taxol-induced Mobility Shift and Phosphorylation of Bcl-2 as Well as for Inhibiting Taxol-induced Cytosolic Accumulation of Cytochrome c and Apoptosis

  Guofu Fang, Brian S. Chang, Caryn N. Kim, Charles Perkins, Craig B. Thompson and Kapil N. Bhalla

  Cancer Res August 1 1998 58 (15) 3202-3208;

  
  
• Advances in Brief

  Inhibition of Vascular Endothelial Growth Factor-induced Receptor Activation with Anti-Kinase Insert Domain-containing Receptor Single-Chain Antibodies from a Phage Display Library

  Zhenping Zhu, Patricia Rockwell, Dan Lu, Helen Kotanides, Bronislaw Pytowski, Daniel J. Hicklin, Peter Bohlen and Larry Witte

  Cancer Res August 1 1998 58 (15) 3209-3214;

  
  
• Advances in Brief

  Modulation of Apoptotic Response of a Radiation-resistant Human Carcinoma by Pseudomonas Exotoxin-Chimeric Protein

  Saraswathy Seetharam, Edwardine Nodzenski, Michael A. Beckett, Ruth Heimann, Amy Cha, Inger Margulies, Ira Pastan, Donald W. Kufe and Ralph R. Weichselbaum

  Cancer Res August 1 1998 58 (15) 3215-3220;

  
  
• Advances in Brief

  Induction of Potent Antitumor Natural Killer Cell Activity by Herpes Simplex Virus-Thymidine Kinase and Ganciclovir Therapy in an Orthotopic Mouse Model of Prostate Cancer

  Simon J. Hall, Michael A. Sanford, Gertrude Atkinson and Shu-Hsia Chen

  Cancer Res August 1 1998 58 (15) 3221-3225;

  
  
• Advances in Brief

  Identification of a Consistent Region of Allelic Loss on 1p32 in Meningiomas: Correlation with Increased Morbidity

  Erik P. Sulman, Jan P. Dumanski, Peter S. White, Huaqing Zhao, John M. Maris, Tiit Mathiesen, Carl Bruder, Avital Cnaan and Garrett M. Brodeur

  Cancer Res August 1 1998 58 (15) 3226-3230;

  
  
• Advances in Brief

  Negative Regulation of Wee1 Expression and Cdc2 Phosphorylation during p53-mediated Growth Arrest and Apoptosis

  Steven D. Leach, Caroline D. Scatena, Christopher J. Keefer, Holly A. Goodman, Si Young Song, Liying Yang and Jennifer A. Pietenpol

  Cancer Res August 1 1998 58 (15) 3231-3236;

  
  
• Advances in Brief

  Characterization of a Breast Cancer Cell Line Derived from a Germ-Line BRCA1 Mutation Carrier

  Gail E. Tomlinson, Tina T-L. Chen, Victor A. Stastny, Arvind K. Virmani, Monique A. Spillman, Vijay Tonk, Joanne L. Blum, Nancy R. Schneider, Ignacio I. Wistuba, Jerry W. Shay, John D. Minna and Adi F. Gazdar

  Cancer Res August 1 1998 58 (15) 3237-3242;

  
  
• Advances in Brief

  Regulation of the M_r 72,000 Type IV Collagenase by the Type I Insulin-like Growth Factor Receptor

  Li Long, Roya Navab and Pnina Brodt

  Cancer Res August 1 1998 58 (15) 3243-3247;

  
  
• Advances in Brief

  Unpredicted Clinical Pharmacology of UCN-01 Caused by Specific Binding to Human α₁-Acid Glycoprotein

  Eiichi Fuse, Hiromi Tanii, Noriaki Kurata, Hiroyuki Kobayashi, Yasuhiro Shimada, Tomohide Tamura, Yasutsuna Sasaki, Yusuke Tanigawara, Richard D. Lush, Donna Headlee, William D. Figg, Susan G. Arbuck, Adrian M. Senderowicz, Edward A. Sausville, Shiro Akinaga, Takashi Kuwabara and Satoshi Kobayashi

  Cancer Res August 1 1998 58 (15) 3248-3253;

  
  
• Advances in Brief

  PTEN Mutations and Microsatellite Instability in Complex Atypical Hyperplasia, a Precursor Lesion to Uterine Endometrioid Carcinoma

  Ross L. Levine, Colyn B. Cargile, Marian S. Blazes, Bastiaan van Rees, Robert J. Kurman and Lora Hedrick Ellenson

  Cancer Res August 1 1998 58 (15) 3254-3258;

  
  
• Advances in Brief

  Human Breast Cancer Cells Contain an Error-prone DNA Replication Apparatus

  Jennifer W. Sekowski, Linda H. Malkas, Lauren Schnaper, Pamela E. Bechtel, Brian J. Long and Robert J. Hickey

  Cancer Res August 1 1998 58 (15) 3259-3263;

  
  
• Advances in Brief

  A Unique Form of Proliferating Cell Nuclear Antigen Is Present in Malignant Breast Cells

  Pamela E. Bechtel, Robert J. Hickey, Lauren Schnaper, Jennifer W. Sekowski, Brian J. Long, Robert Freund, Ni Liu, Carla Rodriguez-Valenzuela and Linda H. Malkas

  Cancer Res August 1 1998 58 (15) 3264-3269;

  
  
• Advances in Brief

  Interleukin 15 Offers Selective Protection from Irinotecan-induced Intestinal Toxicity in a Preclinical Animal Model

  Shousong Cao, Jennifer D. Black, Anthony B. Troutt and Youcef M. Rustum

  Cancer Res August 1 1998 58 (15) 3270-3274;

  
  
• Biochemistry and Biophysics

  Radiation-induced Apoptosis Mediated by Retinoblastoma Protein

  Cai Bowen, Sarah Spiegel and Edward P. Gelmann

  Cancer Res August 1 1998 58 (15) 3275-3281;

  
  
• Carcinogenesis

  Influence of N-Methyl-N-Nitrosourea, Testosterone, and N-(4-Hydroxyphenyl)-all-trans-retinamide on Prostate Cancer Induction in Wistar-Unilever Rats

  David L. McCormick, K. V. N. Rao, Lawrence Dooley, Vernon E. Steele, Ronald A. Lubet, Gary J. Kelloff and Maarten C. Bosland

  Cancer Res August 1 1998 58 (15) 3282-3288;

  
  
• Carcinogenesis

  K-ras Codon 12 Mutation Determines the Polypoid Growth of Colorectal Cancer

  Jy-Ming Chiang, Yah-Huei Wu Chou and Tze-Bin Chou

  Cancer Res August 1 1998 58 (15) 3289-3293;

  
  
• Clinical Investigations

  Soluble Receptor for Urokinase Plasminogen Activator in Both Full-Length and a Cleaved Form Is Present in High Concentration in Cystic Fluid from Ovarian Cancer

  Karin Wahlberg, Gunilla Høyer-Hansen and Bertil Casslén

  Cancer Res August 1 1998 58 (15) 3294-3298;

  
  
• Endocrinology

  Development of an Androgen Receptor-null Model for Identifying the Initiation Site for Androgen Stimulation of Proliferation and Suppression of Programmed (Apoptotic) Death of PC-82 Human Prostate Cancer Cells

  Jin Gao and John T. Isaacs

  Cancer Res August 1 1998 58 (15) 3299-3306;

  
  
• Epidemiology and Prevention

  A Prospective Study of N-Acetyltransferase Genotype, Red Meat Intake, and Risk of Colorectal Cancer

  Jia Chen, Meir J. Stampfer, Heather L. Hough, Montserrat Garcia-Closas, Walter C. Willett, Charles H. Hennekens, Karl T. Kelsey and David J. Hunter

  Cancer Res August 1 1998 58 (15) 3307-3311;

  
  
• Experimental Therapeutics

  Dietary Ω-3 Polyunsaturated Fatty Acids Promote Colon Carcinoma Metastasis in Rat Liver

  Patrizia Griffini, Olav Fehres, Lars Klieverik, Ilse M. C. Vogels, Wikky Tigchelaar, Susanne M. Smorenburg and Cornelis J. F. Van Noorden

  Cancer Res August 1 1998 58 (15) 3312-3319;

  
  
• Experimental Therapeutics

  In Vitro and in Vivo Targeting of Immunoliposomal Doxorubicin to Human B-Cell Lymphoma

  Daniel E. Lopes de Menezes, Linda M. Pilarski and Theresa M. Allen

  Cancer Res August 1 1998 58 (15) 3320-3330;

  
  
• Experimental Therapeutics

  Bcl-x_L Is Phosphorylated in Malignant Cells following Microtubule Disruption

  Marianne S. Poruchynsky, Emily E. Wang, Charles M. Rudin, Mikhail V. Blagosklonny and Tito Fojo

  Cancer Res August 1 1998 58 (15) 3331-3338;

  
  
• Experimental Therapeutics

  Regional Pharmacokinetics of Doxorubicin following Hepatic Arterial and Portal Venous Administration: Evaluation with Hepatic Venous Isolation and Charcoal Hemoperfusion

  Takeshi Iwasaki, Yonson Ku, Nobuya Kusunoki, Masahiro Tominaga, Takumi Fukumoto, Sanshiro Muramatsu and Yoshikazu Kuroda

  Cancer Res August 1 1998 58 (15) 3339-3343;

  
  
• Experimental Therapeutics

  Ligand for Peroxisome Proliferator-activated Receptor γ (Troglitazone) Has Potent Antitumor Effect against Human Prostate Cancer Both in Vitro and in Vivo

  Tetsuya Kubota, Kozo Koshizuka, Elizabeth A. Williamson, Hiroya Asou, Jonathan W. Said, Stuart Holden, Isao Miyoshi and H. Phillip Koeffler

  Cancer Res August 1 1998 58 (15) 3344-3352;

  
  
• Experimental Therapeutics

  A Dominant Negative Mutant of the Insulin-like Growth Factor-I Receptor Inhibits the Adhesion, Invasion, and Metastasis of Breast Cancer

  Sandra E. Dunn, Michael Ehrlich, Nicholas J. H. Sharp, Kris Reiss, Gregory Solomon, Rebecca Hawkins, Renato Baserga and J. Carl Barrett

  Cancer Res August 1 1998 58 (15) 3353-3361;

  
  
• Experimental Therapeutics

  Viral Vector-targeted Antiangiogenic Gene Therapy Utilizing an Angiostatin Complementary DNA

  Toshihide Tanaka, Yihai Cao, Judah Folkman and Howard A. Fine

  Cancer Res August 1 1998 58 (15) 3362-3369;

  
  
• Experimental Therapeutics

  19-nor-26,27-bishomo-Vitamin D₃ Analogs: A Unique Class of Potent Inhibitors of Proliferation of Prostate, Breast, and Hematopoietic Cancer Cells

  Tetsuya Kubota, Kozo Koshizuka, Michiaki Koike, Milan Uskokovic, Isao Miyoshi and H. Phillip Koeffler

  Cancer Res August 1 1998 58 (15) 3370-3375;

  
  
• Immunology

  Maturation of Cytotoxic T Lymphocytes against a B7-transfected Nonmetastatic Tumor: A Critical Role for Costimulation by B7 on Both Tumor and Host Antigen-presenting Cells

  Maja Maric, Pan Zheng, Supria Sarma, Yong Guo and Yang Liu

  Cancer Res August 1 1998 58 (15) 3376-3384;

  
  
• Immunology

  A Novel Hydrophobized Polysaccharide/Oncoprotein Complex Vaccine Induces in Vitro and in Vivo Cellular and Humoral Immune Responses against HER2-expressing Murine Sarcomas

  Xiao-Gang Gu, Michael Schmitt, Atsunori Hiasa, Yasuhiro Nagata, Hiroaki Ikeda, Yoshihiro Sasaki, Kazunari Akiyoshi, Junzo Sunamoto, Hideo Nakamura, Kagemasa Kuribayashi and Hiroshi Shiku

  Cancer Res August 1 1998 58 (15) 3385-3390;

  
  
• Molecular Biology and Genetics

  Inhibition of Fas (CD95) Expression and Fas-mediated Apoptosis by Oncogenic Ras

  Robert G. Fenton, Julie A. Hixon, Paul W. Wright, Alan D. Brooks and Thomas J. Sayers

  Cancer Res August 1 1998 58 (15) 3391-3400;

  
  
• Molecular Biology and Genetics

  The Murine Fhit Locus: Isolation, Characterization, and Expression in Normal and Tumor Cells

  Yuri Pekarsky, Teresa Druck, Maria Grazia Cotticelli, Masataka Ohta, Jiang Shou, Jeannine Mendrola, Jeffry C. Montgomery, Arthur M. Buchberg, Linda D. Siracusa, Giacomo Manenti, Louise Y. Y. Fong, Tommaso A. Dragani, Carlo M. Croce and Kay Huebner

  Cancer Res August 1 1998 58 (15) 3401-3408;

  
  
• Molecular Biology and Genetics

  The Murine Fhit Gene Is Highly Similar to Its Human Orthologue and Maps to a Common Fragile Site Region

  Thomas W. Glover, Ann W. Hoge, Diane E. Miller, June E. Ascara-Wilke, Ayla N. Adam, Susan L. Dagenais, Charles M. Wilke, Herman A. Dierick and David G. Beer

  Cancer Res August 1 1998 58 (15) 3409-3414;

  
  
• Molecular Biology and Genetics

  ErbB-4 Ribozymes Abolish Neuregulin-induced Mitogenesis

  Careen K. Tang, David J. Goldstein, Jennifer Payne, Frank Czubayko, Maurizio Alimandi, Ling-Mei Wang, Jacalyn H. Pierce and Marc E. Lippman

  Cancer Res August 1 1998 58 (15) 3415-3422;

  
  
• Molecular Biology and Genetics

  Altered Expression of Ubiquitous Kinesin Heavy Chain Results in Resistance to Etoposide and Hypersensitivity to Colchicine: Mapping of the Domain Associated with Drug Response

  Sergey A. Axenovich, Alexander R. Kazarov, Alexander D. Boiko, Gabriella Armin, Igor B. Roninson and Andrei V. Gudkov

  Cancer Res August 1 1998 58 (15) 3423-3428;

  
  
• Molecular Biology and Genetics

  Methylation of the 5′ CpG Island of the FHIT Gene Is Closely Associated with Transcriptional Inactivation in Esophageal Squamous Cell Carcinomas

  Hisashi Tanaka, Yutaka Shimada, Hideki Harada, Masayuki Shinoda, Syunzo Hatooka, Masayuki Imamura and Kanji Ishizaki

  Cancer Res August 1 1998 58 (15) 3429-3434;

  
  
• Molecular Biology and Genetics

  Complex Genetic Response of Human Cells to Sublethal Levels of Pure Nitric Oxide

  John C. Marquis and Bruce Demple

  Cancer Res August 1 1998 58 (15) 3435-3440;

  
  
• Molecular Biology and Genetics

  Cells Deleted for Brca2 COOH Terminus Exhibit Hypersensitivity to γ-Radiation and Premature Senescence

  Masami Morimatsu, Greg Donoho and Paul Hasty

  Cancer Res August 1 1998 58 (15) 3441-3447;

  
  
• Molecular Biology and Genetics

  Overexpression of p27^Kip1 Inhibits the Growth of Both Normal and Transformed Human Mammary Epithelial Cells

  Alessandro Sgambato, Yu-Jing Zhang, Marco Ciaparrone, Jae-Won Soh, Achille Cittadini, Regina M. Santella and I. Bernard Bernard Weinstein

  Cancer Res August 1 1998 58 (15) 3448-3454;

  
  
• Molecular Biology and Genetics

  Hypermethylation of the hMLH1 Promoter in Colon Cancer with Microsatellite Instability

  Julie M. Cunningham, Eric R. Christensen, David J. Tester, Cheong-Yong Kim, Patrick C. Roche, Lawrence J. Burgart and Stephen N. Thibodeau

  Cancer Res August 1 1998 58 (15) 3455-3460;

  
  
• Tumor Biology

  Effect of Nucleoside Analogue BCH-4556 on Prostate Cancer Growth and Metastases in Vitro and in Vivo

  Shafaat A. Rabbani, Penelope Harakidas, Terry Bowlin and Giorgio Attardo

  Cancer Res August 1 1998 58 (15) 3461-3465;

  
  
• Tumor Biology

  Extended Survivability of Prostate Cancer Cells in the Absence of Trophic Factors: Increased Proliferation, Evasion of Apoptosis, and the Role of Apoptosis Proteins

  Dean G. Tang, Li Li, Dharam P. Chopra and Arthur T. Porter

  Cancer Res August 1 1998 58 (15) 3466-3479;

  
  
• Meeting Report

  Seventh International Workshop on Ataxia-Telangiectasia

  Nancy Uhrhammer, Jacques-Olivier Bay and Yves-Jean Bignon

  Cancer Res August 1 1998 58 (15) 3480-3485;

  
  
• Articles

  Announcements

  Cancer Res August 1 1998 58 (15) 3486-3488;

  
  
• Articles

  Errata

  Cancer Res August 1 1998 58 (15) 3488-3488;