Table of Contents

Articles

• Advances in Brief

  Angiogenesis in the Hollow Fiber Tumor Model Influences Drug Delivery to Tumor Cells: Implications for Anticancer Drug Screening Programs

  Roger M. Phillips, Jennifer Pearce, Paul M. Loadman, Michael C. Bibby, Patricia A. Cooper, David J. Swaine and John A. Double

  Cancer Res December 1 1998 58 (23) 5263-5266;

  
  
• Advances in Brief

  Pathogenesis of Adenocarcinoma in Peutz-Jeghers Syndrome

  Stephen B. Gruber, Mark M. Entius, Gloria M. Petersen, Steven J. Laken, Patti A. Longo, Rebecca Boyer, Albert M. Levin, Urvi J. Mujumdar, Jeffrey M. Trent, Kenneth W. Kinzler, Bert Vogelstein, Stanley R. Hamilton, Mihael H. Polymeropoulos, G. Johan Offerhaus and Francis M. Giardiello

  Cancer Res December 1 1998 58 (23) 5267-5270;

  
  
• Advances in Brief

  Propagation of Genetically Altered Tumor Cells Derived from Fine-Needle Aspirates of Primary Breast Carcinoma

  Zheng Li, Valerie Bustos, Joshua Miner, Eileen Paulo, Zhen Hang Meng, Galina Zlotnikov, Britt-Marie Ljung and Shanaz H. Dairkee

  Cancer Res December 1 1998 58 (23) 5271-5274;

  
  
• Advances in Brief

  Induction of Brain Tumors in Mice Using a Recombinant Platelet-derived Growth Factor B-Chain Retrovirus

  Lene Uhrbom, Göran Hesselager, Monica Nistér and Bengt Westermark

  Cancer Res December 1 1998 58 (23) 5275-5279;

  
  
• Advances in Brief

  Increased Expression of Hypoxia Inducible Factor-1α in Rat and Human Prostate Cancer

  Hua Zhong, Faton Agani, Angelo A. Baccala, Erik Laughner, Natalia Rioseco-Camacho, William B. Isaacs, Jonathan W. Simons and Gregg L. Semenza

  Cancer Res December 1 1998 58 (23) 5280-5284;

  
  
• Advances in Brief

  Adenoviral Transgene Expression of MMAC/PTEN in Human Glioma Cells Inhibits Akt Activation and Induces Anoikis

  Michael A. Davies, Yiling Lu, Tetsuro Sano, Xianjun Fang, Ping Tang, Ruth LaPushin, Dimpy Koul, Robert Bookstein, David Stokoe, W. K. Alfred Yung, Gordon B. Mills and Peter A. Steck

  Cancer Res December 1 1998 58 (23) 5285-5290;

  
  
• Advances in Brief

  Association between Lung Cancer and Microsomal Epoxide Hydrolase Genotypes

  Simone Benhamou, Maria Reinikainen, Christine Bouchardy, Pierre Dayer and Ari Hirvonen

  Cancer Res December 1 1998 58 (23) 5291-5293;

  
  
• Advances in Brief

  The Bisphosphonate Incadronate (YM175) Causes Apoptosis of Human Myeloma Cells in Vitro by Inhibiting the Mevalonate Pathway

  Claire M. Shipman, Peter I. Croucher, R. Graham, G. Russell, Miep H. Helfrich and Michael J. Rogers

  Cancer Res December 1 1998 58 (23) 5294-5297;

  
  
• Advances in Brief

  Absence of Topoisomerase IIβ in an Amsacrine-resistant Human Leukemia Cell Line with Mutant Topoisomerase IIα

  Cynthia E. Herzog, Katherine A. Holmes, Laura M. Tuschong, Ram Ganapathi and Leonard A. Zwelling

  Cancer Res December 1 1998 58 (23) 5298-5300;

  
  
• Advances in Brief

  Realization of the Therapeutic Potential of CTLA-4 Blockade in Low-Dose Chemotherapy-treated Tumor-bearing Mice

  Margalit B. Mokyr, Tatiana Kalinichenko, Leonid Gorelik and Jeffrey A. Bluestone

  Cancer Res December 1 1998 58 (23) 5301-5304;

  
  
• Advances in Brief

  Generation of CD8⁺ and CD4⁺ T-Cell Response to Dendritic Cells Genetically Engineered to Express the MART-1/Melan-A Gene

  Ainhoa Pérez-Díez, Lisa H. Butterfield, Li Li, Nitya G. Chakraborty, James S. Economou and Bijay Mukherji

  Cancer Res December 1 1998 58 (23) 5305-5309;

  
  
• Advances in Brief

  Methylation of the Androgen Receptor Promoter CpG Island Is Associated with Loss of Androgen Receptor Expression in Prostate Cancer Cells

  David F. Jarrard, Hidefumi Kinoshita, Yan Shi, Carol Sandefur, Douglas Hoff, Lorraine F. Meisner, Chawnshang Chang, James G. Herman, William B. Isaacs and Nadine Nassif

  Cancer Res December 1 1998 58 (23) 5310-5314;

  
  
• Advances in Brief

  IAP-Family Protein Survivin Inhibits Caspase Activity and Apoptosis Induced by Fas (CD95), Bax, Caspases, and Anticancer Drugs

  Ingo Tamm, Yan Wang, Ed Sausville, Dominic A. Scudiero, Nicole Vigna, Tilman Oltersdorf and John C. Reed

  Cancer Res December 1 1998 58 (23) 5315-5320;

  
  
• Advances in Brief

  A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-1 Promoter Creates an Ets Binding Site and Augments Transcription

  Joni L. Rutter, Teresa I. Mitchell, Giovanna Butticè, Jennifer Meyers, James F. Gusella, Laurie J. Ozelius and Constance E. Brinckerhoff

  Cancer Res December 1 1998 58 (23) 5321-5325;

  
  
• Advances in Brief

  An Improved Method for Construction of Directionally Cloned cDNA Libraries from Microdissected Cells

  Lisa A. Peterson, Monica R. Brown, Alex J. Carlisle, Elise C. Kohn, Lance A. Liotta, Michael R. Emmert-Buck and David B. Krizman

  Cancer Res December 1 1998 58 (23) 5326-5328;

  
  
• Advances in Brief

  Genetic Alterations of the Transforming Growth Factor β Receptor Genes in Pancreatic and Biliary Adenocarcinomas

  Michael Goggins, Manu Shekher, Kenan Turnacioglu, Charles J. Yeo, Ralph H. Hruban and Scott E. Kern

  Cancer Res December 1 1998 58 (23) 5329-5332;

  
  
• Advances in Brief

  Inactivation of the p53 Tumor Suppressor Gene via a Novel Alu Rearrangement

  Robbert J. C. Slebos, Michael A. Resnick and Jack A. Taylor

  Cancer Res December 1 1998 58 (23) 5333-5336;

  
  
• Advances in Brief

  A Human Placenta-specific ATP-Binding Cassette Gene (ABCP) on Chromosome 4q22 That Is Involved in Multidrug Resistance

  Rando Allikmets, Lynn M. Schriml, Amy Hutchinson, Vincenzo Romano-Spica and Michael Dean

  Cancer Res December 1 1998 58 (23) 5337-5339;

  
  
• Advances in Brief

  Catalytic Efficiencies of Allelic Variants of Human Glutathione S-transferase P1-1 toward Carcinogenic anti-Diol Epoxides of Benzo[c]phenanthrene and Benzo[g]chrysene

  Xun Hu, Hong Xia, Sanjay K. Srivastava, Ajai Pal, Yogesh C. Awasthi, Piotr Zimniak and Shivendra V. Singh

  Cancer Res December 1 1998 58 (23) 5340-5343;

  
  
• Advances in Brief

  Absent or Low Expression of the ζ Chain in T Cells at the Tumor Site Correlates with Poor Survival in Patients with Oral Carcinoma

  Torsten E. Reichert, Roger Day, Eva M. Wagner and Theresa L. Whiteside

  Cancer Res December 1 1998 58 (23) 5344-5347;

  
  
• Advances in Brief

  Presence and Location of TP53 Mutation Determines Pattern of CDKN2A/ARF Pathway Inactivation in Bladder Cancer

  Isabel D. C. Markl and Peter A. Jones

  Cancer Res December 1 1998 58 (23) 5348-5353;

  
  
• Carcinogenesis

  Prevention of NNK-induced Lung Tumorigenesis in A/J Mice by Acetylsalicylic Acid and NS-398

  Nathalie Rioux and Andre Castonguay

  Cancer Res December 1 1998 58 (23) 5354-5360;

  
  
• Carcinogenesis

  The Augmentation of Melanocytic Nevi in Guinea Pigs by Solar-simulated Light: An Animal Model for Human Melanocytic Nevi

  Scott Menzies, Mamdouh Khalil, Kerry Crotty and Antonio Bonin

  Cancer Res December 1 1998 58 (23) 5361-5366;

  
  
• Carcinogenesis

  Differential Expression of Estrogen Receptor-α and -β Messenger RNAs as a Potential Marker of Ovarian Carcinogenesis

  Pascal Pujol, Jean-Marc Rey, Philippe Nirde, Pascal Roger, Marguerite Gastaldi, François Laffargue, Henri Rochefort and Thierry Maudelonde

  Cancer Res December 1 1998 58 (23) 5367-5373;

  
  
• Clinical Investigations

  Protection of Metabolic and Exercise Capacity in Unselected Weight-losing Cancer Patients following Treatment with Recombinant Erythropoietin: A Randomized Prospective Study

  Peter Daneryd, Elisabeth Svanberg, Ulla Körner, Elisabeth Lindholm, Rolf Sandström, Hans Brevinge, Cecilia Pettersson, Ingvar Bosaeus and Kent Lundholm

  Cancer Res December 1 1998 58 (23) 5374-5379;

  
  
• Epidemiology and Prevention

  α-Difluoromethylornithine Inhibits N-Nitrosomethylbenzylamine-induced Esophageal Carcinogenesis in Zinc-deficient Rats: Effects on Esophageal Cell Proliferation and Apoptosis

  Louise Y. Y. Fong, Anthony E. Pegg and Peter N. Magee

  Cancer Res December 1 1998 58 (23) 5380-5388;

  
  
• Experimental Therapeutics

  3-(Iodoacetamido)-benzoylurea: A Novel Cancericidal Tubulin Ligand that Inhibits Microtubule Polymerization, Phosphorylates bcl-2, and Induces Apoptosis in Tumor Cells

  Jian-Dong Jiang, Ashley S. Davis, Kim Middleton, Yi-He Ling, Roman Perez-Soler, James F. Holland and J. George Bekesi

  Cancer Res December 1 1998 58 (23) 5389-5395;

  
  
• Experimental Therapeutics

  Drug Resistance Patterns of Human Neuroblastoma Cell Lines Derived from Patients at Different Phases of Therapy

  Nino Keshelava, Robert C. Seeger, Susan Groshen and C. Patrick Reynolds

  Cancer Res December 1 1998 58 (23) 5396-5405;

  
  
• Experimental Therapeutics

  Attenuation of Telomerase Activity by a Hammerhead Ribozyme Targeting the Template Region of Telomerase RNA in Endometrial Carcinoma Cells

  Yasuhiro Yokoyama, Yuichiro Takahashi, Ariyoshi Shinohara, Zenglin Lian, Xiaoyun Wan, Kenji Niwa and Teruhiko Tamaya

  Cancer Res December 1 1998 58 (23) 5406-5410;

  
  
• Experimental Therapeutics

  (E)-2′-Deoxy-2′-(fluoromethylene) Cytidine Potentiates Radioresponse of Two Human Solid Tumor Xenografts

  Lin-Quan Sun, Ye-Xiong Li, Louis Guillou and Philippe A. Coucke

  Cancer Res December 1 1998 58 (23) 5411-5417;

  
  
• Experimental Therapeutics

  Expression, Characterization, and Detection of Human Uridine Phosphorylase and Identification of Variant Uridine Phosphorolytic Activity in Selected Human Tumors

  Mengping Liu, Deliang Cao, Rosalind Russell, Robert E. Handschumacher and Giuseppe Pizzorno

  Cancer Res December 1 1998 58 (23) 5418-5424;

  
  
• Experimental Therapeutics

  Photodynamic Therapy of Orthotopic Prostate Cancer with Benzoporphyrin Derivative: Local Control and Distant Metastasis

  Tetsuo Momma, Michael R. Hamblin, Horace C. Wu and Tayyaba Hasan

  Cancer Res December 1 1998 58 (23) 5425-5431;

  
  
• Experimental Therapeutics

  Inhibition of Insulin-like Growth Factor I Receptor Expression in Neuroblastoma Cells Induces the Regression of Established Tumors in Mice

  Xiangdang Liu, Thomas Turbyville, Anne Fritz and Luke Whitesell

  Cancer Res December 1 1998 58 (23) 5432-5438;

  
  
• Immunology

  EblacZ Tumor Dormancy in Bone Marrow and Lymph Nodes: Active Control of Proliferating Tumor Cells by CD8⁺ Immune T Cells

  Markus Müller, Fotini Gounari, Sophia Prifti, Hans Jörg Hacker, Volker Schirrmacher and Khashayarsha Khazaie

  Cancer Res December 1 1998 58 (23) 5439-5446;

  
  
• Immunology

  Immunity to p53 Induced by an Idiotypic Network of Anti-p53 Antibodies: Generation of Sequence-specific Anti-DNA Antibodies and Protection from Tumor Metastasis

  Neta Erez-Alon, Johannes Herkel, Roland Wolkowicz, Pedro J. Ruiz, Ari Waisman, Varda Rotter and Irun R. Cohen

  Cancer Res December 1 1998 58 (23) 5447-5452;

  
  
• Molecular Biology and Genetics

  The Relationships between p53-dependent Apoptosis, Inhibition of Proliferation, and 5-Fluorouracil-induced Histopathology in Murine Intestinal Epithelia

  D. Mark Pritchard, Christopher S. Potten and John A. Hickman

  Cancer Res December 1 1998 58 (23) 5453-5465;

  
  
• Molecular Biology and Genetics

  Expression of AP-2 Transcription Factors in Human Breast Cancer Correlates with the Regulation of Multiple Growth Factor Signalling Pathways

  Bruce C. Turner, Jian Zhang, Andrew A. Gumbs, Mary G. Maher, Leni Kaplan, Darryl Carter, Peter M. Glazer, Helen C. Hurst, Bruce G. Haffty and Trevor Williams

  Cancer Res December 1 1998 58 (23) 5466-5472;

  
  
• Molecular Biology and Genetics

  Reduced COX-2 Protein in Colorectal Cancer with Defective Mismatch Repair

  William E. Karnes Jr., Rebecca Shattuck-Brandt, Lawrence J. Burgart, Raymond N. DuBois, David J. Tester, Julie M. Cunningham, Cheong-Yong Kim, Shannon K. McDonnell, Daniel J. Schaid and Stephen N. Thibodeau

  Cancer Res December 1 1998 58 (23) 5473-5477;

  
  
• Molecular Biology and Genetics

  Clinicopathological Significance of Fhit Protein Expression in Stage I Non-Small Cell Lung Carcinoma

  Yoshio Tomizawa, Takashi Nakajima, Takashi Kohno, Ryusei Saito, Naohito Yamaguchi and Jun Yokota

  Cancer Res December 1 1998 58 (23) 5478-5483;

  
  
• Molecular Biology and Genetics

  Nuclear Factor κB Dominant Negative Genetic Constructs Inhibit X-ray Induction of Cell Adhesion Molecules in the Vascular Endothelium

  Dennis E. Hallahan, Subbulakshmi Virudachalam and Jaya Kuchibhotla

  Cancer Res December 1 1998 58 (23) 5484-5488;

  
  
• Molecular Biology and Genetics

  Aging and DNA Methylation in Colorectal Mucosa and Cancer

  Nita Ahuja, Qing Li, Avinash L. Mohan, Stephen B. Baylin and Jean-Pierre J. Issa

  Cancer Res December 1 1998 58 (23) 5489-5494;

  
  
• Tumor Biology

  Heat Shock Protein 27 Enhances the Tumorigenicity of Immunogenic Rat Colon Carcinoma Cell Clones

  Carmen Garrido, Annie Fromentin, Bernard Bonnotte, Nathalie Favre, Monique Moutet, André-Patrick Arrigo, Patrick Mehlen and Eric Solary

  Cancer Res December 1 1998 58 (23) 5495-5499;

  
  
• Tumor Biology

  The Matrix Metalloproteinase Matrilysin Influences Early-Stage Mammary Tumorigenesis

  Laura A. Rudolph-Owen, Richard Chan, William J. Muller and Lynn M. Matrisian

  Cancer Res December 1 1998 58 (23) 5500-5506;

  
  
• Tumor Biology

  Abundance of Heat Shock Proteins (hsp89, hsp60, and hsp27) in Malignant Cells of Hodgkin's Disease

  Pei-Ling Hsu and Su-Ming Hsu

  Cancer Res December 1 1998 58 (23) 5507-5513;

  
  
• Tumor Biology

  Generation of Hepatocytes from Oval Cell Precursors in Culture

  Catherine A. Lázaro, Jonathan A. Rhim, Yasuhiro Yamada and Nelson Fausto

  Cancer Res December 1 1998 58 (23) 5514-5522;

  
  
• Tumor Biology

  The RET/PTC3 Oncogene: Metastatic Solid-Type Papillary Carcinomas in Murine Thyroids

  Daniel J. Powell Jr., John Russell, Ken-ichi Nibu, Guoqi Li, Ed Rhee, Mickey Liao, Michael Goldstein, William M. Keane, Massimo Santoro, Alfredo Fusco and Jay L. Rothstein

  Cancer Res December 1 1998 58 (23) 5523-5528;

  
  
• Tumor Biology

  SPARC/Osteonectin Induces Matrix Metalloproteinase 2 Activation in Human Breast Cancer Cell Lines

  Christine Gilles, James A. Bassuk, Helena Pulyaeva, E. Helene Sage, Jean-Michel Foidart and Erik W. Thompson

  Cancer Res December 1 1998 58 (23) 5529-5536;

  
  
• Tumor Biology

  Association of the Decreased Expression of α3β1 Integrin with the Altered Cell: Environmental Interactions and Enhanced Soft Agar Cloning Ability of c-myc-overexpressing Small Cell Lung Cancer Cells

  Linda F. Barr, Susan E. Campbell, Bruce S. Bochner and Chi V. Dang

  Cancer Res December 1 1998 58 (23) 5537-5545;

  
  
• Tumor Biology

  Mucin Gene Expression in Ovarian Cancers

  Robert L. Giuntoli II, Gustavo C. Rodriguez, Regina S. Whitaker, Richard Dodge and Judith A. Voynow

  Cancer Res December 1 1998 58 (23) 5546-5550;

  
  
• Tumor Biology

  Retinoic Acid and Interferon α Act Synergistically as Antiangiogenic and Antitumor Agents against Human Head and Neck Squamous Cell Carcinoma

  Mark W. Lingen, Peter J. Polverini and Noël P. Bouck

  Cancer Res December 1 1998 58 (23) 5551-5558;

  
  
• Tumor Biology

  Prognostic Value of β1,6-Branched Oligosaccharides in Human Colorectal Carcinoma

  Walter K. F. Seelentag, Wei-Ping Li, Shu-Fang Hsu Schmitz, Urs Metzger, Peter Aeberhard, Philipp U. Heitz and Jürgen Roth

  Cancer Res December 1 1998 58 (23) 5559-5564;

  
  
• Tumor Biology

  Vascular Endothelial Growth Factor Inhibits Apoptotic Death in Hematopoietic Cells after Exposure to Chemotherapeutic Drugs by Inducing MCL1 Acting as an Antiapoptotic Factor

  Osamu Katoh, Toshiaki Takahashi, Tetsuya Oguri, Ken Kuramoto, Keiichiro Mihara, Masao Kobayashi, Shitau Hirata and Hiromitsu Watanabe

  Cancer Res December 1 1998 58 (23) 5565-5569;

  
  
• Tumor Biology

  Bcl-2-mediated Resistance to Apoptosis Is Associated with Glutathione-induced Inhibition of AP24 Activation of Nuclear DNA Fragmentation

  Susan C. Wright, Hong Wang, Qi Sheng Wei, David H. Kinder and James W. Larrick

  Cancer Res December 1 1998 58 (23) 5570-5576;

  
  
• Tumor Biology

  MUC1 Synthetic Peptide Inhibition of Intercellular Adhesion Molecule-1 and MUC1 Binding Requires Six Tandem Repeats

  Janice L. Kam, Lyle H. Regimbald, Joseph H. M. Hilgers, Pat Hoffman, Mark J. Krantz, B. Michael Longenecker and Judith C. Hugh

  Cancer Res December 1 1998 58 (23) 5577-5581;

  
  
• Tumor Biology

  MUC1 Is A Novel Marker for the Type II Pneumocyte Lineage during Lung Carcinogenesis

  Julia A. Jarrard, R. Ilona Linnoila, HyeRan Lee, Seth M. Steinberg, Hanspeter Witschi and Eva Szabo

  Cancer Res December 1 1998 58 (23) 5582-5589;

  
  
• Research Task Force Report

  Report from THE MARCH Research Task Force

  Ellen V. Sigal and Anna D. Barker

  Cancer Res December 1 1998 58 (23) 5590-5627;

  
  
• Articles

  Announcements

  Cancer Res December 1 1998 58 (23) 5628-5629;

  
  
• Announcement

  Recent Death

  Cancer Res December 1 1998 58 (23) 5629-5629;

  
  
• Announcements

  Calendar of Events

  Cancer Res December 1 1998 58 (23) 5629-5630;

  
  
• Articles

  Erratum

  Cancer Res December 1 1998 58 (23) 5630-5630;