Table of Contents

Articles

• Advances in Brief

  Regulation of E2F4 Mitogenic Activity during Terminal Differentiation by Its Heterodimerization Partners for Nuclear Translocation

  Pier Lorenzo Puri, Letizia Cimino, Marcella Fulco, Christian Zimmerman, Nicholas B. La Thangue, Antonio Giordano, Adolf Graessmann and Massimo Levrero

  Cancer Res April 1 1998 58 (7) 1325-1331;

  
  
• Advances in Brief

  Amplification of the ATP-Binding Cassette 2 Transporter Gene Is Functionally Linked with Enhanced Efflux of Estramustine in Ovarian Carcinoma Cells

  Naomi M. Laing, Martin G. Belinsky, Gary D. Kruh, Daphne W. Bell, Jonathan T. Boyd, Linda Barone, Joseph R. Testa and Kenneth D. Tew

  Cancer Res April 1 1998 58 (7) 1332-1337;

  
  
• Advances in Brief

  Thymic Lymphomas in Mice with a Truncating Mutation in Brca2

  Lori S. Friedman, Fiona C. Thistlethwaite, Ketan J. Petel, Veronica P. C. C. Yu, Hyunsook Lee, Ashok R. Venkitaraman, Kenneth J. Abel, Mark B. L. Carlton, Susan M. Hunter, William H. Colledge, Martin J. Evans and Bruce A. J. Ponder

  Cancer Res April 1 1998 58 (7) 1338-1343;

  
  
• Advances in Brief

  Mutations in the β-Catenin Gene (CTNNB1) in Endometrioid Ovarian Carcinomas

  José Palacios and Carlos Gamallo

  Cancer Res April 1 1998 58 (7) 1344-1347;

  
  
• Advances in Brief

  Expression of Lumican in Human Breast Carcinoma

  Etienne Leygue, Linda Snell, Helmut Dotzlaw, Kate Hole, Tamara Hiller-Hitchcock, Peter J. Roughley, Peter H. Watson and Leigh C. Murphy

  Cancer Res April 1 1998 58 (7) 1348-1352;

  
  
• Advances in Brief

  Amplification, Expression, and Steroid Regulation of the Preprogalanin Gene in Human Breast Cancer

  Christopher J. Ormandy, Christine S. L. Lee, Helen F. Ormandy, Vera Fantl, John Shine, Gordon Peters and Robert L. Sutherland

  Cancer Res April 1 1998 58 (7) 1353-1357;

  
  
• Advances in Brief

  Adenoviral-mediated Transfer of a Heat-inducible Double Suicide Gene into Prostate Carcinoma Cells

  Robert V. Blackburn, Sandra S. Galoforo, Peter M. Corry and Yong J. Lee

  Cancer Res April 1 1998 58 (7) 1358-1362;

  
  
• Advances in Brief

  Human Melanoma-specific, Noncytolytic CD8+ T Cells That Can Synthesize Type I Cytokine

  Nitya G. Chakraborty and Bijay Mukherji

  Cancer Res April 1 1998 58 (7) 1363-1366;

  
  
• Advances in Brief

  BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of the Disease

  Karin Haraldsson, Niklas Loman, Qiu-Xia Zhang, Oskar Johannsson, Håkan Olsson and Åke Borg

  Cancer Res April 1 1998 58 (7) 1367-1371;

  
  
• Advances in Brief

  A Large Deletion Disrupts the Exon 3 Transcription Activation Domain of the BRCA2 Gene in a Breast/Ovarian Cancer Family

  Margareta Nordling, Per Karlsson, Jan Wahlström, Yvonne Engwall, Arne Wallgren and Tommy Martinsson

  Cancer Res April 1 1998 58 (7) 1372-1375;

  
  
• Advances in Brief

  The Role of Ataxia-Telangiectasia Heterozygotes in Familial Breast Cancer

  Jindong Chen, Gabriella Giesler Birkholtz, Per Lindblom, Carlos Rubio and Annika Lindblom

  Cancer Res April 1 1998 58 (7) 1376-1379;

  
  
• Advances in Brief

  Search for Mutations and Examination of Allelic Expression Imbalance of the p73 Gene at 1p36.33 in Human Lung Cancers

  Shuji Nomoto, Nobuhiro Haruki, Masashi Kondo, Hiroyuki Konishi, Takao Takahashi, Toshitada Takahashi and Takashi Takahashi

  Cancer Res April 1 1998 58 (7) 1380-1383;

  
  
• Advances in Brief

  Low Frequency of Somatic Mutations in the LKB1/Peutz-Jeghers Syndrome Gene in Sporadic Breast Cancer

  Graham R. Bignell, Rita Barfoot, Sheila Seal, Nadine Collins, William Warren and Michael R. Stratton

  Cancer Res April 1 1998 58 (7) 1384-1386;

  
  
• Advances in Brief

  Linkage of Familial Wilms' Tumor Predisposition to Chromosome 19 and a Two-Locus Model for the Etiology of Familial Tumors

  J. Matthew McDonald, Edwin C. Douglass, Ross Fisher, Clementina F. Geiser, Carl E. Krill, Louise C. Strong, David Virshup and Vicki Huff

  Cancer Res April 1 1998 58 (7) 1387-1390;

  
  
• Advances in Brief

  Down-Regulation of Homeobox Gene GBX2 Expression Inhibits Human Prostate Cancer Clonogenic Ability and Tumorigenicity

  Allen C. Gao, Wei Lou and John T. Isaacs

  Cancer Res April 1 1998 58 (7) 1391-1394;

  
  
• Advances in Brief

  Increased Incidence of Matrix Metalloproteinases in Urine of Cancer Patients

  Marsha A. Moses, Dmitri Wiederschain, Kevin R. Loughlin, David Zurakowski, Carolyn C. Lamb and Michael R. Freeman

  Cancer Res April 1 1998 58 (7) 1395-1399;

  
  
• Advances in Brief

  DNA Interstrand Cross-Links Induced by Psoralen Are Not Repaired in Mammalian Mitochondria

  Carleen Cullinane and Vilhelm A. Bohr

  Cancer Res April 1 1998 58 (7) 1400-1404;

  
  
• Advances in Brief

  Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients

  Kenji Hibi, C. Rahj Robinson, Susan Booker, Li Wu, Stanley R. Hamilton, David Sidransky and Jin Jen

  Cancer Res April 1 1998 58 (7) 1405-1407;

  
  
• Review

  The Unique Physiology of Solid Tumors: Opportunities (and Problems) for Cancer Therapy

  J. Martin Brown and Amato J. Giaccia

  Cancer Res April 1 1998 58 (7) 1408-1416;

  
  
• Biochemistry and Biophysics

  A Relevant Dose of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Is Extensively Metabolized and Rapidly Absorbed in the Canine Tracheal Mucosa

  Per Gerde, Bruce A. Muggenburg, Tony Stephens, Johnnye L. Lewis, Kee H. Pyon and Alan R. Dahl

  Cancer Res April 1 1998 58 (7) 1417-1422;

  
  
• Biochemistry and Biophysics

  Differential Selectivity of Ligands for the C1a and C1b Phorbol Ester Binding Domains of Protein Kinase Cδ: Possible Correlation with Tumor-promoting Activity

  Krisztina Bögi, Patricia S. Lorenzo, Zoltán Szállási, Péter Ács, Gerhardt S. Wagner and Peter M. Blumberg

  Cancer Res April 1 1998 58 (7) 1423-1428;

  
  
• Carcinogenesis

  Overexpression of the Myristoylated Alanine-rich C Kinase Substrate in Human Choroidal Melanoma Cells Affects Cell Proliferation

  Stéphane Manenti, François Malecaze, Hugues Chap and Jean-Marie Darbon

  Cancer Res April 1 1998 58 (7) 1429-1434;

  
  
• Carcinogenesis

  Topical Retinoic Acid Reduces Skin Papilloma Formation but Resistant Papillomas Are at High Risk for Malignant Conversion

  Tamar Tennenbaum, David Lowry, Nadine Darwiche, David L. Morgan, Marina Gartsbein, Laura Hansen, Luigi M. De Luca, Henry Hennings and Stuart H. Yuspa

  Cancer Res April 1 1998 58 (7) 1435-1443;

  
  
• Carcinogenesis

  Differential Expression of Methionine Adenosyltransferase Genes Influences the Rate of Growth of Human Hepatocellular Carcinoma Cells

  Jiaxin Cai, Zebin Mao, Jung-Joo Hwang and Shelly C. Lu

  Cancer Res April 1 1998 58 (7) 1444-1450;

  
  
• Clinical Investigations

  Prognostic Value of P53 Gene Mutations in a Large Series of Node-negative Breast Cancer Patients

  Nicole Falette, Marie-Pierre Paperin, Isabelle Treilleux, Anne-Christelle Gratadour, Nadine Peloux, Hervé Mignotte, Nigel Tooke, Esfir Löfman, Mats Inganäs, Alain Bremond, Mehmet Ozturk and Alain Puisieux

  Cancer Res April 1 1998 58 (7) 1451-1455;

  
  
• Clinical Investigations

  Combined Nested RT-PCR Assay for Prostate-specific Antigen and Prostate-specific Membrane Antigen in Prostate Cancer Patients: Correlation with Pathological Stage

  Ying Z. Grasso, Manjula K. Gupta, Howard S. Levin, Craig D. Zippe and Eric A. Klein

  Cancer Res April 1 1998 58 (7) 1456-1459;

  
  
• Experimental Therapeutics

  Chinese Hamster Ovary Cells Resistant to the Topoisomerase II Catalytic Inhibitor ICRF-159: A Tyr49Phe Mutation Confers High-Level Resistance to Bisdioxopiperazines

  Maxwell Sehested, Irene Wessel, Lars H. Jensen, Bente Holm, Roberto S. Oliveri, Sue Kenwrick, Andrew M. Creighton, John L. Nitiss and Peter B. Jensen

  Cancer Res April 1 1998 58 (7) 1460-1468;

  
  
• Immunology

  Mice Transgenic for Human Carcinoembryonic Antigen as a Model for Immunotherapy

  Patrick Clarke, Jeffrey Mann, Jean F. Simpson, Karen Rickard-Dickson and F. James Primus

  Cancer Res April 1 1998 58 (7) 1469-1477;

  
  
• Immunology

  Interleukin 2 Expression by Tumor Cells Alters Both the Immune Response and the Tumor Microenvironment

  Jungeun Lee, Bruce M. Fenton, Cameron J. Koch, John G. Frelinger and Edith M. Lord

  Cancer Res April 1 1998 58 (7) 1478-1485;

  
  
• Immunology

  Reduction of Established Spontaneous Mammary Carcinoma Metastases following Immunotherapy with Major Histocompatibility Complex Class II and B7.1 Cell-based Tumor Vaccines

  Beth A. Pulaski and Suzanne Ostrand-Rosenberg

  Cancer Res April 1 1998 58 (7) 1486-1493;

  
  
• Molecular Biology and Genetics

  Clinicopathological Significance of Altered Loci of Replication Error and Microsatellite Instability-associated Mutations in Gastric Cancer

  Ming-Shiang Wu, Chung-Wei Lee, Chia-Tung Shun, Hsiu-Po Wang, Wei-Jei Lee, Jin-Chuan Sheu and Jaw-Town Lin

  Cancer Res April 1 1998 58 (7) 1494-1497;

  
  
• Molecular Biology and Genetics

  Direct Modulation of Tumor Suppressor Connexin 26 Gene by Human Chorionic Gonadotropin in Rat Mammary Glands

  Shaojin You, Zheng-Jin Tu and David T. Kiang

  Cancer Res April 1 1998 58 (7) 1498-1502;

  
  
• Molecular Biology and Genetics

  Characteristic Pattern of Chromosomal Gains and Losses in Merkel Cell Carcinoma Detected by Comparative Genomic Hybridization

  Mireille Van Gele, Frank Speleman, Jo Vandesompele, Nadine Van Roy and J. Helen Leonard

  Cancer Res April 1 1998 58 (7) 1503-1508;

  
  
• Molecular Biology and Genetics

  Inhibition of Growth of Malignant Rat Prostate Tumor Cells by Restoration of Fibroblast Growth Factor Receptor 2

  Akio Matsubara, Mikio Kan, Shuju Feng and Wallace L. McKeehan

  Cancer Res April 1 1998 58 (7) 1509-1514;

  
  
• Molecular Biology and Genetics

  Down-Regulation of the Novel Gene Melastatin Correlates with Potential for Melanoma Metastasis

  Lyn M. Duncan, Jim Deeds, John Hunter, Jing Shao, Lisa M. Holmgren, Elizabeth A. Woolf, Robert I. Tepper and Andrew W. Shyjan

  Cancer Res April 1 1998 58 (7) 1515-1520;

  
  
• Molecular Biology and Genetics

  Comparative Decreases in Tyrosinase, TRP-1, TRP-2, and Pmel 17/Silver Antigenic Proteins from Melanotic to Amelanotic Stages of Syngeneic Mouse Cutaneous Melanomas and Metastases

  Seth J. Orlow, Willys K. Silvers, Bao-Kang Zhou and Beatrice Mintz

  Cancer Res April 1 1998 58 (7) 1521-1523;

  
  
• Tumor Biology

  Role of Nitric Oxide and Superoxide Anion in Elimination of Low Metastatic Human Colorectal Carcinomas by Unstimulated Hepatic Sinusoidal Endothelial Cells

  Kirsten H. Edmiston, Yutaka Shoji, Takayuki Mizoi, Rosilyn Ford, Alexander Nachman and J. Milburn Jessup

  Cancer Res April 1 1998 58 (7) 1524-1531;

  
  
• Tumor Biology

  Regulation of Interleukin 8 Expression in Human Malignant Melanoma Cells

  Rakesh K. Singh and Michelle L. Varney

  Cancer Res April 1 1998 58 (7) 1532-1537;

  
  
• Tumor Biology

  Overexpressed WAF1/Cip1 Renders Glioblastoma Cells Resistant to Chemotherapy Agents 1,3-Bis(2-chloroethyl)-1-nitrosourea and Cisplatin

  Sanbao Ruan, M. Fatih Okcu, Jiang Ping Ren, Paul Chiao, Michael Andreeff, Victor Levin and Wei Zhang

  Cancer Res April 1 1998 58 (7) 1538-1543;

  
  
• Tumor Biology

  Enhanced Expression of α(1,3)-Fucosyltransferase Genes Correlates with E-selectin-mediated Adhesion and Metastatic Potential of Human Lung Adenocarcinoma Cells

  Mireia Martín-Satué, Rosabel Marrugat, José A. Cancelas and Jerónimo Blanco

  Cancer Res April 1 1998 58 (7) 1544-1550;

  
  
• Tumor Biology

  Regulation of Expression of Thymidine Phosphorylase/Platelet-derived Endothelial Cell Growth Factor in Human Colon Carcinoma Cells

  Edward L. Schwartz, Emily Wan, Fu-Shen Wang and Nicole Baptiste

  Cancer Res April 1 1998 58 (7) 1551-1557;

  
  
• Tumor Biology

  Expression of Human Telomerase Subunits and Correlation with Telomerase Activity in Cervical Cancer

  Masahiro Takakura, Satoru Kyo, Taro Kanaya, Masaaki Tanaka and Masaki Inoue

  Cancer Res April 1 1998 58 (7) 1558-1561;

  
  
• Tumor Biology

  In Vivo Electron Paramagnetic Resonance Imaging of Tumor Heterogeneity and Oxygenation in a Murine Model

  Periannan Kuppusamy, Mobae Afeworki, Ravi A. Shankar, Deborah Coffin, Murali C. Krishna, Stephen M. Hahn, James B. Mitchell and Jay L. Zweier

  Cancer Res April 1 1998 58 (7) 1562-1568;

  
  
• Tumor Biology

  Targeted Disruption of the β1 Integrin Gene in a Lymphoma Cell Line Greatly Reduces Metastatic Capacity

  Peter J. M. Stroeken, Ellen A. M. van Rijthoven, Martin A. van der Valk and Ed Roos

  Cancer Res April 1 1998 58 (7) 1569-1577;

  
  
• Articles

  Announcements

  Cancer Res April 1 1998 58 (7) 1578-1580;

  
  
• Articles

  Erratum

  Cancer Res April 1 1998 58 (7) 1580-1580;