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Advances in Brief

Frequent Abnormalities of the Putative Tumor Suppressor Gene FHIT at 3p14.2 in Pancreatic Carcinoma Cell Lines

Babette Simon, Detlef Bartsch, Peter Barth, Nicole Prasnikar, Karin Münch, Andreas Blum, Rudolf Arnold and Burkhard Göke
Babette Simon
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Detlef Bartsch
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Peter Barth
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Nicole Prasnikar
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Karin Münch
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Andreas Blum
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Rudolf Arnold
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Burkhard Göke
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DOI:  Published April 1998
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Abstract

The FHIT gene is localized on chromosome 3p14, a region including a tumor cell-specific, commonly deleted region. To determine the role of the FHIT gene in pancreatic carcinogenesis, 14 pancreatic carcinoma cell lines were analyzed by reverse transcription-PCR and exon-specific PCR amplification of genomic DNA. The full-length FHIT transcript was lost in 70% of the pancreatic carcinoma cell lines analyzed, while 66% also revealed intragenic homozygous deletions of exons, 3, 4, and 5. Truncated FHIT transcripts lacking a variable number of exons most likely represented alternative splicing products. Fhit protein expression was dependent on a full-length FHIT transcript. The results suggest that the FHIT gene may be a target tumor suppressor gene involved in pancreatic carcinogenesis.

Footnotes

  • ↵1 This work was supported by grants from the Alfred und Ursula Kulemann Stiftung and the Deutsche Forschungsgemeinschaft, Grant Si 383/3-1 (to B. S.), and the Kempkes Stiftung and the Deutsche Forschungsgemeinschaft, Grant Ba 1487/2-1 (to D. B.).

  • ↵2 To whom requests for reprints should be addressed, at Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University, Marburg/Germany. Phone: (49) 6421 28 2721; Fax: (49) 6421 28 2799; E-mail: simonb@post.med.uni-marburg.de.

  • Received October 8, 1997.
  • Accepted February 18, 1998.
  • ©1998 American Association for Cancer Research.
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April 1998
Volume 58, Issue 8
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Frequent Abnormalities of the Putative Tumor Suppressor Gene FHIT at 3p14.2 in Pancreatic Carcinoma Cell Lines
Babette Simon, Detlef Bartsch, Peter Barth, Nicole Prasnikar, Karin Münch, Andreas Blum, Rudolf Arnold and Burkhard Göke
Cancer Res April 15 1998 (58) (8) 1583-1587;

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Frequent Abnormalities of the Putative Tumor Suppressor Gene FHIT at 3p14.2 in Pancreatic Carcinoma Cell Lines
Babette Simon, Detlef Bartsch, Peter Barth, Nicole Prasnikar, Karin Münch, Andreas Blum, Rudolf Arnold and Burkhard Göke
Cancer Res April 15 1998 (58) (8) 1583-1587;
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