Article Figures & Data
Figures
- Fig. 1.
PCR amplification of genomic DNA sequences that include the polymorphic site in the MMP-1 promoter region. A 148-bp band corresponds to the 1G (deletion-type) allele and a 149-bp band corresponds to the 2G (insertion-type) allele. As positive controls, we used genomic DNAs with genotypes for the insertion/deletion polymorphism that had been determined by direct sequencing (bottom).
- Fig. 2.
A, expression of the MMP-1 gene according to genotype for the insertion/deletion polymorphism in ovarian cancers. Bottom, ratios of MMP-1 expression level against corresponding β-2 microglobulin expression. B, plot of the ratios of MMP-1 expression against corresponding β -2 microglobulin expression for each genotype of the polymorphism. Horizontal lines, medians of each group.
Tables
- Table 1
Frequency of each genotype of the MMP-1 promoter
No. 1G/1G 1G/2G 2G/2G Controls 150 30 (0.20) 56 (0.37) 64 (0.43) Ovarian Cancera 163 18 (0.11) 84 (0.52)b 61 (0.37)b -
a Normal tissue samples from ovarian cancer patients. The relative frequency of each genotype is shown in parantheses.
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b The frequency of 1G/2G and 2G/2G genotypes in ovarian cancers (89%) was higher than that in controls (80%; P = 0.028).
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Volume 59, Issue 17
