Article Figures & Data
Figures
- Fig. 1.
Structure of ONO-8711.
- Fig. 2.
Effect of ONO-8711 on the size distribution of intestinal polyps in Min mice. Mice were fed the basal diet (open columns) or a diet containing 500 ppm of ONO-8711 (filled columns) for 7 weeks. Polyps were grouped at intervals of 0.5 mm according to their diameters. The number of polyps per mouse in each group is presented as the mean; bars, SE. *, P < 0.05, versus basal diet group; **, P < 0.01 versus basal diet group.
Tables
- Table 1
Effect of EP1 receptor deficiency on AOM-induced ACF formation in the mouse colon
Mice Mice with ACFs ACFs/colona Mean of ACs/focusa Wild type 10/10 11.8 ± 1.3 1.7 ± 0.1 EP1−/− 9/9 7.6 ± 1.1b 1.6 ± 0.1 -
a Data are means ± SE.
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b P < 0.05 versus wild type.
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- Table 2
Inhibition of AOM-induced ACF development in the colons of C57BL/6J mice by ONO-8711
Treatment Intake of ONO-8711(mg/kg/day) Mice with ACFs ACFs/colona Mean of ACs/focusa Basal diet 10/10 16.3 ± 1.2 1.4 ± 0.1 Mice fed ONO-8711 during and post-AOM ONO-8711 (250 ppm) 37 10/10 12.7 ± 1.0 (22)b,c 1.4 ± 0.1 ONO-8711 (500 ppm) 71 10/10 11.3 ± 1.4 (31)c 1.3 ± 0.1 ONO-8711 (1000 ppm) 141 10/10 10.6 ± 1.2 (35)d 1.3 ± 0.0 Mice fed ONO-8711 post-AOM ONO-8711 (250 ppm) 35 10/10 13.4 ± 1.7 1.4 ± 0.1 ONO-8711 (500 ppm) 72 10/10 12.5 ± 1.7 1.3 ± 0.1 ONO-8711 (1000 ppm) 137 10/10 11.3 ± 0.9 (31)d 1.2 ± 0.0 -
a Data are means ± SE.
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b Numbers in parentheses indicate percentage of inhibition compared with the basal diet group.
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c Versus basal diet:
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d P < 0.01.
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- Table 3
Inhibition of intestinal polyp development by ONO-8711 in Min micea
No. of polyps per mouseb Polyp location Basal diet ONO-8711 Proximal small intestine 2.3 ± 0.9 1.4 ± 0.3 Middle small intestine 13.2 ± 1.7 8.1 ± 1.4 c Distal small intestine 42.9 ± 6.2 23.1 ± 2.9 d Colon 0.9 ± 0.2 0.8 ± 0.2 Total 59.3 ± 7.3 33.4 ± 4.3d -
a Mice were fed the basal diet or a diet containing 500 ppm of ONO-8711 for 7 weeks.
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b Data are means ± SE.
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c Versus basal diet group:
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d P < 0.01.
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Volume 59, Issue 20
