Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Advances in Brief

Arsenic Trioxide Causes Selective Necrosis in Solid Murine Tumors by Vascular Shutdown

Young S. Lew, Stephen L. Brown, Robert J. Griffin, Chang W. Song and Jae Ho Kim
Young S. Lew
Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 [Y. S. L., S. L. B., J. H. K.] and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 [R. J. G., C. W. S.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen L. Brown
Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 [Y. S. L., S. L. B., J. H. K.] and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 [R. J. G., C. W. S.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert J. Griffin
Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 [Y. S. L., S. L. B., J. H. K.] and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 [R. J. G., C. W. S.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chang W. Song
Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 [Y. S. L., S. L. B., J. H. K.] and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 [R. J. G., C. W. S.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jae Ho Kim
Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 [Y. S. L., S. L. B., J. H. K.] and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 [R. J. G., C. W. S.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published December 1999
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Fig. 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 1.

    Morphological features of Meth-A tumors in BALB/c mice. A, sequential gross morphological changes before and after the administration of As2O3 (10 mg/kg i.p.). B–G, histological features of the tumors stained with H&E. B–D, ×25 magnification; E–G, ×400 magnification. V, nonnecrotic zone; N, necrotic zone.

  • Fig. 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 2.

    Effect of As2O3 on the growth of Meth-A tumors in BALB/c mice. ○, untreated control group (vehicle only); •, As2O3 group, 10 mg/kg i.p. The arrowheads indicate the times of As2O3 administration. Data are the means of five animals per group. Bars, SE.

  • Fig. 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 3.

    Effect of As2O3 (10 mg/kg) on the blood perfusion in Meth-A tumors in the BALB/c mice measured by 86Rb uptake and 99mTc clearance. Each point represents the mean of >10 mice for the rubidium uptake and 6 mice for 99mTc clearance. Bars, SE.

  • Fig. 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 4.

    Changes in blood perfusion as a function of time in normal tissues and Meth-A tumor measured by 86Rb uptake. Values are the means of >10 mice at each time point.

PreviousNext
Back to top
December 1999
Volume 59, Issue 24
  • Table of Contents

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Arsenic Trioxide Causes Selective Necrosis in Solid Murine Tumors by Vascular Shutdown
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Arsenic Trioxide Causes Selective Necrosis in Solid Murine Tumors by Vascular Shutdown
Young S. Lew, Stephen L. Brown, Robert J. Griffin, Chang W. Song and Jae Ho Kim
Cancer Res December 15 1999 (59) (24) 6033-6037;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Arsenic Trioxide Causes Selective Necrosis in Solid Murine Tumors by Vascular Shutdown
Young S. Lew, Stephen L. Brown, Robert J. Griffin, Chang W. Song and Jae Ho Kim
Cancer Res December 15 1999 (59) (24) 6033-6037;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response
  • Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis
  • 2-Arachidonoylglycerol
Show more Advances in Brief
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement