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Advances in Brief

Comparative Genomic Hybridization of Breast Tumors Stratified by Histological Grade Reveals New Insights into the Biological Progression of Breast Cancer

Rebecca Roylance, Patricia Gorman, William Harris, Rachael Liebmann, Diana Barnes, Andrew Hanby and Denise Sheer
Rebecca Roylance
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Patricia Gorman
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William Harris
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Rachael Liebmann
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Diana Barnes
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Andrew Hanby
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Denise Sheer
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DOI:  Published April 1999
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    Fig. 1.

    Chromosomal aberrations detected by CGH in breast carcinomas. Top, gains and losses of genetic material in 40 grade I breast carcinomas. Gains are represented by bars to the right of the chromosomal ideograms, and losses are represented by bars to the left; standard thresholds for gains and losses are used (see “Materials and Methods”). Each bar represents data from a single tumor; three tumors had no changes and are not represented. Bottom, data from 50 grade III breast carcinomas, represented in the same way. All tumors showed at least one change.

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    Fig. 2.

    Frequency of chromosomal aberrations in breast carcinomas. Top, chromosomal aberrations in grade I breast carcinomas. Each bar on the X axis represents either the short arm (▪) or long arm (▧) of each chromosome. The size of each bar represents the percentage of tumors showing that particular aberration. Gains are represented as positive changes, and losses are represented as negative changes. Bottom, chromosomal aberrations in grade III breast carcinomas depicted in the same way. The difference between the top and bottom graphs with regard to loss of chromosome 16q is clearly apparent.

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April 1999
Volume 59, Issue 7
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Comparative Genomic Hybridization of Breast Tumors Stratified by Histological Grade Reveals New Insights into the Biological Progression of Breast Cancer
Rebecca Roylance, Patricia Gorman, William Harris, Rachael Liebmann, Diana Barnes, Andrew Hanby and Denise Sheer
Cancer Res April 1 1999 (59) (7) 1433-1436;

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Comparative Genomic Hybridization of Breast Tumors Stratified by Histological Grade Reveals New Insights into the Biological Progression of Breast Cancer
Rebecca Roylance, Patricia Gorman, William Harris, Rachael Liebmann, Diana Barnes, Andrew Hanby and Denise Sheer
Cancer Res April 1 1999 (59) (7) 1433-1436;
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Cancer Research Online ISSN: 1538-7445
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