Breast Cancer Resistance Protein Is Localized at the Plasma Membrane in Mitoxantrone- and Topotecan-resistant Cell Lines

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]

Department of Pathology, Free University Hospital, 1081 HV Amsterdam, the Netherlands [G. L. S., A. C. L. M. P., M. C. d. J., A. B. S., P. v. d. V., R. J. S.]; Division of Experimental Therapy, The Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands [M. M., M. A. v. G., J. D. A., J. H. M. S.]; Department of Hematology and Medical Oncology, Academic Hospital Groningen, 9700RB Groningen, the Netherlands [D. M. v. d. K]; Department of Medicine, Division of Hematology/Oncology, Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201 [D. D. R.]; and Department of Biochemistry, Pharmacology, and Internal Medicine, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 [W. S. D.]