Castration-induced Up-Regulation of Insulin-like Growth Factor Binding Protein-5 Potentiates Insulin-like Growth Factor-I Activity and Accelerates Progression to Androgen Independence in Prostate Cancer Models

The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, V6H 3Z6 [H. M., M. E. G.]; Division of Urology, University of British Columbia, Vancouver, British Columbia V5Z 3J5 [H. M., M. E. G.]; and Lady Davis Research Institute of the Jewish General Hospital and Departments of Medicine and Oncology, McGill University, Montreal, Quebec, H3T 1E2 [M. P.], Canada

The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, V6H 3Z6 [H. M., M. E. G.]; Division of Urology, University of British Columbia, Vancouver, British Columbia V5Z 3J5 [H. M., M. E. G.]; and Lady Davis Research Institute of the Jewish General Hospital and Departments of Medicine and Oncology, McGill University, Montreal, Quebec, H3T 1E2 [M. P.], Canada

The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, V6H 3Z6 [H. M., M. E. G.]; Division of Urology, University of British Columbia, Vancouver, British Columbia V5Z 3J5 [H. M., M. E. G.]; and Lady Davis Research Institute of the Jewish General Hospital and Departments of Medicine and Oncology, McGill University, Montreal, Quebec, H3T 1E2 [M. P.], Canada