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Table of Contents

Review

  • Review
    Estrogens, BRCA1, and Breast Cancer
    Leena Hilakivi-Clarke
    Cancer Res September 15 2000 60 (18) 4993-5001;

Advances in Brief

  • Advances in Brief
    p53 Is Essential for Chemotherapy-induced Hair Loss
    Vladimir A. Botchkarev, Elena A. Komarova, Frank Siebenhaar, Natalia V. Botchkareva, Pavel G. Komarov, Marcus Maurer, Barbara A. Gilchrest and Andrei V. Gudkov
    Cancer Res September 15 2000 60 (18) 5002-5006;

  • Advances in Brief
    Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis
    Kenji Ono, Toshihiro Tanaka, Tatsuhiko Tsunoda, Osamu Kitahara, Chikashi Kihara, Aikou Okamoto, Kazunori Ochiai, Toshihisa Takagi and Yusuke Nakamura
    Cancer Res September 15 2000 60 (18) 5007-5011;

  • Advances in Brief
    Micropthalmia Transcription Factor: A New Prognostic Marker in Intermediate-thickness Cutaneous Malignant Melanoma
    George I. Salti, Taline Manougian, Miguel Farolan, Anne Shilkaitis, Dibyen Majumdar and Tapas K. Das Gupta
    Cancer Res September 15 2000 60 (18) 5012-5016;

  • Advances in Brief
    Population-based Mapping of Pulmonary Adenoma Susceptibility 1 Locus
    Tommaso A. Dragani, Setsuo Hirohashi, Takeo Juji, Kaname Kawajiri, Masahiro Kihara, Masako Ono-Kihara, Giacomo Manenti, Tomoko Nomoto, Haruhiko Sugimura, Keiichiro Genka, Jun Yokota, Takashi Takahashi, Tetsuya Mitsudomi and Minako Nagao
    Cancer Res September 15 2000 60 (18) 5017-5020;

  • Advances in Brief
    Fields of Aberrant CpG Island Hypermethylation in Barrett’s Esophagus and Associated Adenocarcinoma
    Cindy A. Eads, Reginald V. Lord, Soudamini K. Kurumboor, Kumari Wickramasinghe, Margaret L. Skinner, Tiffany I. Long, Jeffrey H. Peters, Tom R. DeMeester, Kathleen D. Danenberg, Peter V. Danenberg, Peter W. Laird and Kristin A. Skinner
    Cancer Res September 15 2000 60 (18) 5021-5026;

  • Advances in Brief
    Pleiotropic Resistance to DNA-interactive Drugs Is Associated with Increased Expression of Genes Involved in DNA Replication, Repair, and Stress Response
    Victor V. Leveonson (Chernokhvostov), Irina A. Davidovich and Igor B. Roninson
    Cancer Res September 15 2000 60 (18) 5027-5030;

  • Advances in Brief
    The Dual Impact of Coxsackie and Adenovirus Receptor Expression on Human Prostate Cancer Gene Therapy
    Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, Jeffrey M. Bergelson, Jian Zhou and Jer-Tsong Hsieh
    Cancer Res September 15 2000 60 (18) 5031-5036;

  • Advances in Brief
    Ataxia Telangiectasia-related Protein Is Involved in the Phosphorylation of BRCA1 following Deoxyribonucleic Acid Damage
    Junjie Chen
    Cancer Res September 15 2000 60 (18) 5037-5039;

  • Advances in Brief
    The Cyclooxygenase-2 Inhibitor Celecoxib Is a Potent Preventive and Therapeutic Agent in the Min Mouse Model of Adenomatous Polyposis
    Russell F. Jacoby, Karen Seibert, Carolyn E. Cole, Gary Kelloff and Ronald A. Lubet
    Cancer Res September 15 2000 60 (18) 5040-5044;

Biochemistry and Biophysics

  • Biochemistry and Biophysics
    Novel Actions of the Antitumor Drugs Vinflunine and Vinorelbine on Microtubules
    Vivian K. Ngan, Krista Bellman, Dulal Panda, Bridget T. Hill, Mary Ann Jordan and Leslie Wilson
    Cancer Res September 15 2000 60 (18) 5045-5051;

  • Biochemistry and Biophysics
    Cell-based Screen for Antimitotic Agents and Identification of Analogues of Rhizoxin, Eleutherobin, and Paclitaxel in Natural Extracts
    Michel Roberge, Bruno Cinel, Hilary J. Anderson, Lynette Lim, Xiuxian Jiang, Lin Xu, Cristina M. Bigg, Michael T. Kelly and Raymond J. Andersen
    Cancer Res September 15 2000 60 (18) 5052-5058;

Carcinogenesis

  • Carcinogenesis
    Inhibitory Effect of Citrus Nobiletin on Phorbol Ester-induced Skin Inflammation, Oxidative Stress, and Tumor Promotion in Mice
    Akira Murakami, Yoshimasa Nakamura, Koji Torikai, Takuji Tanaka, Teruaki Koshiba, Koichi Koshimizu, Shigeru Kuwahara, Yasuo Takahashi, Kazunori Ogawa, Masamichi Yano, Harukuni Tokuda, Hoyoku Nishino, Yoshihiro Mimaki, Yutaka Sashida, Susumu Kitanaka and Hajime Ohigashi
    Cancer Res September 15 2000 60 (18) 5059-5066;

  • Carcinogenesis
    Differential Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinases by Methyl Methanesulfonate in the Liver and Brain of Rats: Implication for Organ-specific Carcinogenesis
    Yousin Suh, Ung Gu Kang, Yong Sik Kim, Woo-Ho Kim, Sang-Chul Park and Joo-Bae Park
    Cancer Res September 15 2000 60 (18) 5067-5073;

  • Carcinogenesis
    Human Cytochrome P450 CYP2A13: Predominant Expression in the Respiratory Tract and Its High Efficiency Metabolic Activation of a Tobacco-specific Carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Ting Su, Ziping Bao, Qing-Yu Zhang, Theresa J. Smith, Jun-Yan Hong and Xinxin Ding
    Cancer Res September 15 2000 60 (18) 5074-5079;

  • Carcinogenesis
    Increased Mutant Frequency and Altered Mutation Spectrum of the lacI Transgene in Wilson Disease Rats with Hepatitis
    Hideko Sone, Ying Jie Li, Mayumi Ishizuka, Yasunobu Aoki and Minako Nagao
    Cancer Res September 15 2000 60 (18) 5080-5086;

  • Carcinogenesis
    Lack of Phenobarbital-mediated Promotion of Hepatocarcinogenesis in Connexin32-Null Mice
    Oliver Moennikes, Albrecht Buchmann, Alessandro Romualdi, Thomas Ott, Jürgen Werringloer, Klaus Willecke and Michael Schwarz
    Cancer Res September 15 2000 60 (18) 5087-5091;

Clinical Investigations

  • Clinical Investigations
    Early Resistance to Therapy during Induction in Childhood Acute Lymphoblastic Leukemia
    Michael J. Brisco, Pamela J. Sykes, Gaynor Dolman, Elizabeth Hughes, Sim-Hee Neoh, Liming Peng, Lesley E. Snell, Ian R. G. Toogood, Michael S. Rice and Alexander A. Morley
    Cancer Res September 15 2000 60 (18) 5092-5096;

Endocrinology

  • Endocrinology
    Allosteric Silencing of Activating Function 1 in the 4-Hydroxytamoxifen Estrogen Receptor Complex Is Induced by Substituting Glycine for Aspartate at Amino Acid 351
    Jennifer MacGregor Schafer, Hong Liu, David J. Bentrem, James W. Zapf and V. Craig Jordan
    Cancer Res September 15 2000 60 (18) 5097-5105;

Epidemiology

  • Epidemiology
    Serum Testosterone:Estradiol Ratio and the Development of Hepatocellular Carcinoma among Male Cirrhotic Patients
    Keitaro Tanaka, Hironori Sakai, Makoto Hashizume and Tomio Hirohata
    Cancer Res September 15 2000 60 (18) 5106-5110;

  • Epidemiology
    Polymorphic CAG and GGN Repeat Lengths in the Androgen Receptor Gene and Prostate Cancer Risk: A Population-based Case-Control Study in China
    Ann W. Hsing, Yu-Tang Gao, Guan Wu, Xin Wang, Jie Deng, Yuh-Ling Chen, Isabell A. Sesterhenn, F. Kash Mostofi, Jacques Benichou and Chawnshang Chang
    Cancer Res September 15 2000 60 (18) 5111-5116;

Experimental Therapeutics

  • Experimental Therapeutics
    Selective Inhibition of Vascular Endothelial Growth Factor (VEGF) Receptor 2 (KDR/Flk-1) Activity by a Monoclonal Anti-VEGF Antibody Blocks Tumor Growth in Mice
    Rolf A. Brekken, Jay P. Overholser, Victor A. Stastny, Johannes Waltenberger, John D. Minna and Philip E. Thorpe
    Cancer Res September 15 2000 60 (18) 5117-5124;

  • Experimental Therapeutics
    Chemoprevention of Prostate Carcinogenesis by α-Difluoromethylornithine in TRAMP Mice
    Sanjay Gupta, Nihal Ahmad, Susan R. Marengo, Gregory T. MacLennan, Norman M. Greenberg and Hasan Mukhtar
    Cancer Res September 15 2000 60 (18) 5125-5133;

  • Experimental Therapeutics
    CD99 Engagement: An Effective Therapeutic Strategy for Ewing Tumors
    Katia Scotlandi, Nicola Baldini, Vanessa Cerisano, Maria Cristina Manara, Stefania Benini, Massimo Serra, Pier-Luigi Lollini, Patrizia Nanni, Giordano Nicoletti, Ghislaine Bernard, Alain Bernard and Piero Picci
    Cancer Res September 15 2000 60 (18) 5134-5142;

  • Experimental Therapeutics
    Intracranial Inhibition of Platelet-derived Growth Factor-mediated Glioblastoma Cell Growth by an Orally Active Kinase Inhibitor of the 2-Phenylaminopyrimidine Class
    Turker Kilic, John A. Alberta, Pawel R. Zdunek, Melih Acar, Palma Iannarelli, Terence O’Reilly, Elisabeth Buchdunger, Peter M. Black and Charles D. Stiles
    Cancer Res September 15 2000 60 (18) 5143-5150;

  • Experimental Therapeutics
    Uroguanylin Treatment Suppresses Polyp Formation in the ApcMin/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP
    Kunwar Shailubhai, Helen H. Yu, Kanthasamy Karunanandaa, Joan Y. Wang, Sammy L. Eber, Yuan Wang, Nam Soo Joo, Hyun Dju Kim, Brent W. Miedema, S. Zaheer Abbas, Sekhar S. Boddupalli, Mark G. Currie and Leonard R. Forte
    Cancer Res September 15 2000 60 (18) 5151-5157;

  • Experimental Therapeutics
    Human Carbonyl Reductase Overexpression in the Heart Advances the Development of Doxorubicin-induced Cardiotoxicity in Transgenic Mice
    Gerald L. Forrest, Basilio Gonzalez, William Tseng, XiuLi Li and Jeffrey Mann
    Cancer Res September 15 2000 60 (18) 5158-5164;

  • Experimental Therapeutics
    Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Suppresses the Growth of Prostate Cancer Cells in Vitro and in Vivo
    Lisa M. Butler, David B. Agus, Howard I. Scher, Brian Higgins, Adam Rose, Carlos Cordon-Cardo, Howard T. Thaler, Richard A. Rifkind, Paul A. Marks and Victoria M. Richon
    Cancer Res September 15 2000 60 (18) 5165-5170;

  • Experimental Therapeutics
    Taxol Mediates Serine Phosphorylation of the 66-kDa Shc Isoform
    Chia-Ping Huang Yang and Susan Band Horwitz
    Cancer Res September 15 2000 60 (18) 5171-5178;

  • Experimental Therapeutics
    Noninvasive Real-Time Monitoring of Intracellular Cancer Cell Metabolism and Response to Lonidamine Treatment Using Diffusion Weighted Proton Magnetic Resonance Spectroscopy
    Yael Mardor, Ofer Kaplan, Marina Sterin, Jesus Ruiz-Cabello, Elissa Ash, Yiftach Roth, Israel Ringel and Jack S. Cohen
    Cancer Res September 15 2000 60 (18) 5179-5186;

  • Experimental Therapeutics
    Direct Reversal of DNA Damage by Mutant Methyltransferase Protein Protects Mice against Dose-intensified Chemotherapy and Leads to in Vivo Selection of Hematopoietic Stem Cells
    Susanne Ragg, Meng Xu-Welliver, Jeff Bailey, Maria D’Souza, Ryan Cooper, Saurabh Chandra, Roopa Seshadri, Anthony E. Pegg and David A. Williams
    Cancer Res September 15 2000 60 (18) 5187-5195;

  • Experimental Therapeutics
    Role of CYP1A1 in Modulation of Antitumor Properties of the Novel Agent 2-(4-Amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in Human Breast Cancer Cells
    Mei-Sze Chua, Eiji Kashiyama, Tracey D. Bradshaw, Sherman F. Stinson, Eileen Brantley, Edward A. Sausville and Malcolm F. G. Stevens
    Cancer Res September 15 2000 60 (18) 5196-5203;

  • Experimental Therapeutics
    Pharmacological Inhibition of Phosphatidylcholine Biosynthesis Is Associated with Induction of Phosphatidylinositol Accumulation and Cytolysis of Neoplastic Cell Lines
    Robert E. Finney, Edward Nudelman, Thayer White, Stuart Bursten, Peter Klein, Laura L. Leer, Nu Wang, David Waggoner, Jack W. Singer and Robert A. Lewis
    Cancer Res September 15 2000 60 (18) 5204-5213;

  • Experimental Therapeutics
    MT-21 Is a Synthetic Apoptosis Inducer That Directly Induces Cytochrome c Release from Mitochondria
    Masahiko Watabe, Kiyotaka Machida and Hiroyuki Osada
    Cancer Res September 15 2000 60 (18) 5214-5222;

Immunology

  • Immunology
    Use of Two Predictive Algorithms of the World Wide Web for the Identification of Tumor-reactive T-Cell Epitopes
    Jun Lu and Esteban Celis
    Cancer Res September 15 2000 60 (18) 5223-5227;

  • Immunology
    Defining Promiscuous MHC Class II Helper T-Cell Epitopes for the HER2/neu Tumor Antigen
    Hiroya Kobayashi, Monique Wood, Yongsheng Song, Ettore Appella and Esteban Celis
    Cancer Res September 15 2000 60 (18) 5228-5236;

  • Immunology
    In Vitro Characterization of Radiolabeled Monoclonal Antibodies Specific for the Extracellular Domain of Prostate-specific Membrane Antigen
    Peter M. Smith-Jones, Shankar Vallabahajosula, Stanley J. Goldsmith, Vincent Navarro, Catherine J. Hunter, Diego Bastidas and Neil H. Bander
    Cancer Res September 15 2000 60 (18) 5237-5243;

Molecular Biology and Genetics

  • Molecular Biology and Genetics
    Loss of p27Kip1 from Cyclin E/Cyclin-dependent Kinase (CDK) 2 but not from Cyclin D1/CDK4 Complexes in Cells Transformed by Polyamine Biosynthetic Enzymes
    Kirsi Ravanko, Kristiina Järvinen, Aino Paasinen-Sohns and Erkki Hölttä
    Cancer Res September 15 2000 60 (18) 5244-5253;

Tumor Biology

  • Tumor Biology
    Tissue-specific Carcinogenesis in Transgenic Mice Expressing the RET Proto-Oncogene with a Multiple Endocrine Neoplasia Type 2A Mutation
    Kumi Kawai, Toshihide Iwashita, Hideki Murakami, Noriko Hiraiwa, Atsushi Yoshiki, Moriaki Kusakabe, Kenzo Ono, Ken-ichi Iida, Atsuo Nakayama and Masahide Takahashi
    Cancer Res September 15 2000 60 (18) 5254-5260;

  • Tumor Biology
    Involvement of Cell Surface Glycans in Adhesion of Human Colon Carcinoma Cells to Liver Tissue in a Frozen Section Assay: Role of Endo-β-galactosidase-sensitive Structures
    Masayuki Ota, Noriaki Takamura and Tatsuro Irimura
    Cancer Res September 15 2000 60 (18) 5261-5268;

  • Tumor Biology
    Specific Detection of Multidrug Resistance Proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Monoclonal Antibodies
    George L. Scheffer, Marcel Kool, Marc Heijn, Marcel de Haas, Adriana C. L. M. Pijnenborg, Jan Wijnholds, Ardy van Helvoort, Mariska C. de Jong, Jan H. Hooijberg, Carla A. A. M. Mol, Marcel van der Linden, J. Marleen L. de Vree, Paul van der Valk, Ronald P. J. Oude Elferink, Piet Borst and Rik J. Scheper
    Cancer Res September 15 2000 60 (18) 5269-5277;

  • Tumor Biology
    Increased Expression of Insulin-like Growth Factor I Receptor in Malignant Cells Expressing Aberrant p53: Functional Impact
    Leonard Girnita, Ada Girnita, Bertha Brodin, Yuntao Xie, Gunnar Nilsson, Anica Dricu, Joakim Lundeberg, Johan Wejde, Armando Bartolazzi, Klas G. Wiman and Olle Larsson
    Cancer Res September 15 2000 60 (18) 5278-5283;

  • Tumor Biology
    Pleiotrophin Can Be Rate-limiting for Pancreatic Cancer Cell Growth
    Dirk Weber, Hans-Jürgen Klomp, Frank Czubayko, Anton Wellstein and Hartmut Juhl
    Cancer Res September 15 2000 60 (18) 5284-5288;

  • Tumor Biology
    Mechanism for the Antitumor and Anticachectic Effects of n-3 Fatty Acids
    Leonard A. Sauer, Robert T. Dauchy and David E. Blask
    Cancer Res September 15 2000 60 (18) 5289-5295;

  • Tumor Biology
    PCD1, a Novel Gene Containing PDZ and LIM Domains, Is Overexpressed in Several Human Cancers
    Sanmao Kang, Haidong Xu, Xiaozhu Duan, Jing-Jie Liu, Zhijun He, Fang Yu, Siliang Zhou, Xian-Qin Meng, Manqiu Cao and Giulia C. Kennedy
    Cancer Res September 15 2000 60 (18) 5296-5302;

  • Tumor Biology
    Prevention of Phosphatidylinositol 3′-Kinase-Akt Survival Signaling Pathway during Topotecan-induced Apoptosis
    Ayako Nakashio, Naoya Fujita, Susumu Rokudai, Saori Sato and Takashi Tsuruo
    Cancer Res September 15 2000 60 (18) 5303-5309;

  • Tumor Biology
    Transactivation of the Epidermal Growth Factor Receptor in Endothelin-1-induced Mitogenic Signaling in Human Ovarian Carcinoma Cells
    Fabrizio Vacca, Anna Bagnato, Kevin J. Catt and Raffaele Tecce
    Cancer Res September 15 2000 60 (18) 5310-5317;

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September 2000
Volume 60, Issue 18
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Cancer Research Online ISSN: 1538-7445
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