Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Advances in Brief

Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis

Kenji Ono, Toshihiro Tanaka, Tatsuhiko Tsunoda, Osamu Kitahara, Chikashi Kihara, Aikou Okamoto, Kazunori Ochiai, Toshihisa Takagi and Yusuke Nakamura
Kenji Ono
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshihiro Tanaka
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tatsuhiko Tsunoda
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Osamu Kitahara
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chikashi Kihara
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aikou Okamoto
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazunori Ochiai
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshihisa Takagi
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yusuke Nakamura
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI:  Published September 2000
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig. 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 1.

    Representative scatter plots of cDNA microarray analysis. Noncancerous ovary tissue (labeled with Cy5) and serous adenocarcinoma (labeled with Cy3) from case 10 were labeled and hybridized to the cDNA microarray. The upper line shows that Cy3 = 2 × Cy5, and the lower line shows that Cy3 = 0.5 × Cy5.

  • Fig. 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 2.

    Genes that were up-regulated (left) or down-regulated (right) in ovarian adenocarcinomas.

  • Fig. 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 3.

    Genes that were expressed differently in serous and mucinous adenocarcinomas.

  • Fig. 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig. 4.

    Validation of microarray data by semiquantitative RT-PCR. a, aRNAs from normal ovarian tissue and mucinous adenocarcinoma from patient 15 were labeled with Cy5-dCTP (green fluorescence) and Cy3-dCTP (red), respectively. The labeled probes were mixed and then hybridized to the cDNA microarray. b, RT-PCR with unamplified total RNA from patient 15.

Tables

  • Figures
  • Table 1

    Clinical characteristics of nine ovarian adenocarcinomas

    Case no.Histopathological typeStage at diagnosisaSize of residual tumor
    2SerousIIIb<2 cm
    12SerousIIIc<2 cm
    13SerousIIIc<2 cm
    4SerousIIIc≧2 cm
    14SerousIIIc≧2 cm
    15MucinousIIaMicrob
    10MucinousIIcMicro
    11MucinousIIcMicro
    8MucinousIIIb<2 cm
    • a Tumors were staged according to International Federation of Gynecology and Obstetrics criteria.

    • b Micro, .

PreviousNext
Back to top
September 2000
Volume 60, Issue 18
  • Table of Contents

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis
Kenji Ono, Toshihiro Tanaka, Tatsuhiko Tsunoda, Osamu Kitahara, Chikashi Kihara, Aikou Okamoto, Kazunori Ochiai, Toshihisa Takagi and Yusuke Nakamura
Cancer Res September 15 2000 (60) (18) 5007-5011;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis
Kenji Ono, Toshihiro Tanaka, Tatsuhiko Tsunoda, Osamu Kitahara, Chikashi Kihara, Aikou Okamoto, Kazunori Ochiai, Toshihisa Takagi and Yusuke Nakamura
Cancer Res September 15 2000 (60) (18) 5007-5011;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response
  • 2-Arachidonoylglycerol
  • Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis
Show more Advances in Brief
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement