Article Figures & Data
Figures
- Fig. 1.
Representative immunostaining of different levels of Mitf expression in two primary cutaneous malignant melanomas.
- Fig. 2.
Kaplan-Meier survival curves of the entire population. A, DFS. B, OS.
- Fig. 3.
Kaplan-Meier survival curves that compare patients with different levels of Mitf expression. DFS and OS were significantly better for those patients whose melanomas stained positive for Mitf [A (DFS), P = 0.0086; B (OS), P = 0.0054)] and for those patients whose melanomas expressed >25% Mitf[ C (DFS), P = 0.023; D (OS), P = 0.039]. DFS was significantly better for those patients whose melanomas expressed> 50% Mitf (E, P = 0.035). OS tended to be better for those patients whose melanomas expressed >50% Mitf (F, P = 0.054).
Tables
- Table 1
Influence of Mitf expression on DFS and OS
Mitf expression N DFSa OSa 0 11 71.36 (P = 0.048) 80.89 (P = 0.077) +1 17 162.32 172.73 +2 13 119.62 120.05 +3 13 b b +4 9 105.8 106.8 Absent 11 71.36 (P = 0.0086) 80.89 (P = 0.0054) Present 52 186.78 187.9 ≤25% 28 127.14 (P = 0.023) 136.68 (P = 0.039) >25% 35 137.84 147.32 ≤50% 41 127.27 (P = 0.035) 133.37 (P = 0.054) >50% 22 212.57 212.64 -
a Mean values in months.
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b All observations were censored; mean values were not calculated.
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- Table 2
Multivariate Cox regression analysis of all prognostic variables
Variable DFS OS Thickness 0.016 a 0.008 Ulceration 0.382 0.586 Histology 0.359 0.366 Location of primary tumor 0.562 0.335 Mitoses/mm2 0.035 0.033 Nodal status 0.012 0.016 Mitf expression 25% 0.008 0.011 -
a Significance shown in bold.
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Volume 60, Issue 18
