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Experimental Therapeutics

Uroguanylin Treatment Suppresses Polyp Formation in the ApcMin/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP

Kunwar Shailubhai, Helen H. Yu, Kanthasamy Karunanandaa, Joan Y. Wang, Sammy L. Eber, Yuan Wang, Nam Soo Joo, Hyun Dju Kim, Brent W. Miedema, S. Zaheer Abbas, Sekhar S. Boddupalli, Mark G. Currie and Leonard R. Forte
Kunwar Shailubhai
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Helen H. Yu
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Kanthasamy Karunanandaa
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Joan Y. Wang
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Sammy L. Eber
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Yuan Wang
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Nam Soo Joo
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Hyun Dju Kim
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Brent W. Miedema
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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S. Zaheer Abbas
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Sekhar S. Boddupalli
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Mark G. Currie
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Leonard R. Forte
Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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DOI:  Published September 2000
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ARTICLE USAGE: February 2001 to December 2019

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Article Information

Volume 60, Issue 18, pp. 5151-5157

PubMed 
11016642

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received November 11, 1999
  • Accepted July 14, 2000
  • Published first September 1, 2000.

Copyright & Usage 
©2000 American Association for Cancer Research.

Author Information

  1. Kunwar Shailubhai,
  2. Helen H. Yu,
  3. Kanthasamy Karunanandaa,
  4. Joan Y. Wang,
  5. Sammy L. Eber,
  6. Yuan Wang,
  7. Nam Soo Joo,
  8. Hyun Dju Kim,
  9. Brent W. Miedema,
  10. S. Zaheer Abbas,
  11. Sekhar S. Boddupalli,
  12. Mark G. Currie, and
  13. Leonard R. Forte1
  1. Cancer Chemoprevention Group Nutrition Sector, [K. S., H. H. Y., K. K., J. Y. W., S. Z. A., S. S. B.], Searle Research and Development [M. G. C.], Monsanto Life Sciences Company, St. Louis, Missouri 63167, and Truman Memorial Veterans Affairs Hospital [S. L. E., Y. W., B. W. M, L. R. F.], Departments of Pharmacology [S. L. E., Y. W., N. S. J., H. D. K., L. R. F.] and Surgery [B. W. M.], Missouri University, Columbia, Missouri 65212
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Uroguanylin Treatment Suppresses Polyp Formation in the ApcMin/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP
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Uroguanylin Treatment Suppresses Polyp Formation in the ApcMin/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP
Kunwar Shailubhai, Helen H. Yu, Kanthasamy Karunanandaa, Joan Y. Wang, Sammy L. Eber, Yuan Wang, Nam Soo Joo, Hyun Dju Kim, Brent W. Miedema, S. Zaheer Abbas, Sekhar S. Boddupalli, Mark G. Currie and Leonard R. Forte
Cancer Res September 15 2000 (60) (18) 5151-5157;

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Uroguanylin Treatment Suppresses Polyp Formation in the ApcMin/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP
Kunwar Shailubhai, Helen H. Yu, Kanthasamy Karunanandaa, Joan Y. Wang, Sammy L. Eber, Yuan Wang, Nam Soo Joo, Hyun Dju Kim, Brent W. Miedema, S. Zaheer Abbas, Sekhar S. Boddupalli, Mark G. Currie and Leonard R. Forte
Cancer Res September 15 2000 (60) (18) 5151-5157;
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