Malonyl-Coenzyme-A Is a Potential Mediator of Cytotoxicity Induced by Fatty-Acid Synthase Inhibition in Human Breast Cancer Cells and Xenografts

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 [E. S. P., J. T., W. F. H., M. L. P., F. P. K.]; Research Resources Branch/Flow Cytometry Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224 [F. J. C.]; and Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218 [G. L. F., C. A. T.]