Article Figures & Data
Figures
- Fig. 1.
A, immunohistochemical staining of cyclin E in NSCLC. Most carcinoma cells were positive for cyclin E. × 100. B, immunohistochemical staining of PCNA in NSCLC. Most carcinoma cells were positive for PCNA. × 100.
- Fig. 2.
a, survival curves of cases with NSCLC according to cyclin E expression. B, survival curves of cases with NSCLC according to PCNA expression. C, survival curves of cases with NSCLC according to cyclin E and PCNA expression status.
Tables
- Table 1
Characteristics and cyclin E expressions of cases with stage I–IIIA
Variable Total Cyclin E expression P Negative Positive Sex NSa Male 164 88 76 Female 78 40 38 Age (mean± SD) NS 62.3± 10.4 Histology NS Adenocarcinoma 148 85 63 Squamous cell carcinoma 85 41 44 Large cell carcinoma 6 2 4 Adenosquamous cell carcinoma 3 3 P stage NS I 98 56 42 II 30 15 15 IIIa 114 57 57 pT factor 0.043 T1 86 53 33 T2 110 54 56 T3 46 21 25 pN factor NS N0 121 69 52 N1 32 16 16 N2 89 43 46 -
a NS, not significant.
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- Table 2
Multivariate prognostic factor analysis
Factors RRa 95% CI P Sex 0.661 0.398–1.099 0.110 Male/female Histology 1.001 0.713–1.400 0.992 Ad/Sq/Lc/Adsq Differentiation 0.899 0.681–1.187 0.453 Poorly/moderate/well P-stage 1.457 1.008–2.105 0.045b I/II/IIIa Complete resection 1.907 1.366–2.663 0.0002b Yes/no Cyclin E expression 1.923 1.190–3.109 0.0076b Negative/positive PCNA expression 1.706 0.957–3.04 0.0702 Negative/positive -
a RR, relative risk; CI, confidence interval.
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b P < 0.05, considered statistically significant.
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January 2000
Volume 60, Issue 2
Volume 60, Issue 2
Prognostic Significance of Cyclin E Overexpression in Resected Non-Small Cell Lung Cancer
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