Association between Survival after Treatment for Breast Cancer and Glutathione S-Transferase P1 Ile105Val Polymorphism

DOI: Published October 2000

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Fig. 1.
Kaplan-Meier function for overall survival among women treated for breast cancer, by GSTP1 Ile¹⁰⁵Val genotype.
Download figure
Open in new tab
Download powerpoint
Fig. 2.
Kaplan-Meier function for overall survival among women treated for breast cancer, by GSTP1 Ile¹⁰⁵Val genotype, according to race and estrogen receptor status. ———, Ile/Ile; ····, Ile/Val; - - - -, Val/Val. A, Caucasian, n = 93 Ile/Ile, n = 80 Ile/Val, n = 19 Val/Val. B, African American, n = 17 Ile/Ile, n = 27 Ile/Val, n = 4 Val/Val. C, estrogen receptor positive, n = 62 Ile/Ile, n = 71 Ile/Val, n = 14 Val/Val. D, estrogen receptor negative, n = 48 Ile/Ile, n = 36 Ile/Val, n = 9 Val/Val.

Table 1

Selected characteristics of 240 women treated for breast cancer, by GSTP1 Ile105Val genotype

	All subjects (%)	GSTP1 codon 105 genotype
	All subjects (%)	Ile/Ile (%)	Ile/Val (%)	Val/Val (%)
Total	240	110	107	23
Age at diagnosis
≤39	26 (10.8)	13 (11.8)	10 (9.4)	3 (13.0)
40–49	82 (34.2)	35 (31.8)	36 (33.6)	11 (47.8)
50–59	71 (29.6)	36 (32.7)	32 (29.9)	3 (13.0)
60–69	42 (17.5)	19 (17.3)	18 (16.8)	5 (21.7)
70+	19 (7.9)	7 (6.4)	11 (10.3)	1 (4.4)
Race
Caucasian	192 (80.0)	93 (84.6)	80 (74.8)	19 (82.6)
African-American	48 (20.0)	17 (15.5)	27 (25.2)	4 (17.4)
Stage
I	65 (27.1)	32 (29.1)	27 (25.2)	6 (26.1)
II, node negative	48 (20.0)	19 (17.3)	23 (21.5)	6 (26.1)
II, node positive	73 (30.4)	38 (34.6)	29 (27.1)	6 (26.1)
III	41 (17.1)	18 (16.4)	19 (17.8)	4 (17.4)
IV	13 (5.4)	3 (2.7)	9 (8.4)	1 (4.4)
Estrogen receptor status
Positive	147 (61.3)	62 (56.4)	71 (66.4)	14 (60.9)
Negative	93 (38.8)	48 (43.6)	36 (33.6)	9 (39.1)
Progesterone receptor status
Positive	111 (46.3)	49 (44.6)	54 (50.5)	8 (34.8)
Negative	129 (53.8)	61 (55.5)	53 (49.5)	15 (65.2)

Table 2

Survival among 240 women treated for breast cancer, by GSTP1 Ile105Val genotype

GSTP1 codon 105 genotype	No. of cases	Deaths	Hazard ratio^a (95% CI)
Ile/Ile	110	35	1 Reference
Ile/Val	107	33	0.8 (0.5–1.3)
Val/Val	23	3	0.3 (0.1–1.0)

a Hazard ratios from Cox proportional hazards model, adjusted for age, race, stage at diagnosis, node status, and estrogen and progesterone receptor status. Trend in hazard ratio associated with number of GSTP1 variant alleles, P = 0.04.