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Advances in Brief

Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Nasopharyngeal Carcinoma

Y. M. Dennis Lo, Sing-Fai Leung, Lisa Y. S. Chan, Anthony T. C. Chan, Kwok-Wai Lo, Philip J. Johnson and Dolly P. Huang
Y. M. Dennis Lo
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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Sing-Fai Leung
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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Lisa Y. S. Chan
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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Anthony T. C. Chan
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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Kwok-Wai Lo
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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Philip J. Johnson
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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Dolly P. Huang
Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C.], Anatomical and Cellular Pathology [K-W. L., D. P. H.], and Clinical Oncology and the Sir Y. K. Pao Cancer Center [S-F. L., A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
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DOI:  Published May 2000
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    Fig. 1.

    Variations in plasma EBV DNA concentration in NPC patients treated with radiation therapy and sampled weekly during the course of treatment. The variation in plasma EBV DNA levels for each patient over time is plotted in a separate graph. The scale of the Y axis has been optimized for the concentration range for each case. X axis, time from the start of blood sampling, with the first day of radiotherapy treatment as day 0. Y axis, the plasma EBV DNA level (in copies/ml).

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    Fig. 2.

    Variations in plasma EBV DNA concentration in NPC patients treated with radiation therapy and sampled daily during the first treatment week and then weekly during the subsequent treatment course. The variation in plasma EBV DNA levels for each patient over time is plotted in a separate graph. The scale of the Y axis has been optimized for the concentration range for each case. X axis, time from the start of blood sampling, with the first day of radiotherapy treatment as day 0. Y axis, the plasma EBV DNA level (in copies/ml).

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    Fig. 3.

    Half-life analysis for plasma EBV DNA decay. The natural logarithm of the plasma EBV DNA concentration (Y axis) is plotted against time (X axis) for the period between the third and seventh weeks of radiation therapy. For patient 2969, the coefficient of correlation (r2) was 0.965, and the slope was −0.172, resulting in a half-life of 4.0 days. For case 0332, r2 was 0.933, and the slope was− 0.127, resulting in a half-life of 5.5 days. For case 0480, r2 was 0.966, and the slope was −0.158, resulting in a half-life of 4.4 days.

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May 2000
Volume 60, Issue 9
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Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Nasopharyngeal Carcinoma
Y. M. Dennis Lo, Sing-Fai Leung, Lisa Y. S. Chan, Anthony T. C. Chan, Kwok-Wai Lo, Philip J. Johnson and Dolly P. Huang
Cancer Res May 1 2000 (60) (9) 2351-2355;

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Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Nasopharyngeal Carcinoma
Y. M. Dennis Lo, Sing-Fai Leung, Lisa Y. S. Chan, Anthony T. C. Chan, Kwok-Wai Lo, Philip J. Johnson and Dolly P. Huang
Cancer Res May 1 2000 (60) (9) 2351-2355;
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