Article Figures & Data
Figures
- Fig. 1.
Apparent loss of contact inhibition in RWPE-1 cells chronically treated with cadmium. A, representative focus (arrowhead) formed by CTPE cells. B, passage-matched control monolayer lacking cell foci. Bar, 100 μm.
- Fig. 2.
A, tumor produced by CTPE cells after inoculation s.c. into a nude mouse. The tumor is a poorly differentiated adenocarcinoma showing pronounced cellular pleiomorphism and frequent mitotic bodies. Bar, 50 μm. B, area of tumor invasion into the subdermal muscle layers. A large number of muscle fibers can be seen in the lower portion of the photomicrograph. Invasion into the muscle was a frequent occurrence, as was invasion into the fat and connective tissue. Bar, 50 μm.
- Fig. 3.
Positive staining for PSA, indicated by the pinkish to reddish-brown color, confirmed that the tumors were derived from human prostatic epithelial cells. Bar, 25 μm.
- Fig. 4.
Analysis of MMP-2 and MMP-9 activity in RWPE-1 and CTPE in conditioned medium. A, zymogram gel showing increased MMP-2 and MMP-9 activity in CTPE conditioned medium. B, quantitative analysis of zymography results. Data expressed as fold-RWPE-1 activity and are represented as means (n = 3); bars, SE.∗ , significant differences from RWPE-1 activity (P < 0.05).
Volume 61, Issue 2
