Article Figures & Data
Figures
- Fig. 1.
Schematic structure of [18F]Galacto-RGD. The glycopeptide shows the characteristic βII’-turn with d-Phe in the i+1 position and the RGD site in a “kinked” conformation responsible for the αvβ3 selectivity.
- Fig. 2.
Comparison of the biodistribution data of [18F]Galacto-RGD in melanoma M21 (▪)- and M21-L (▵)-bearing nude mice. Error bars, 1 SD. For some data points, error bars are not visible because the SD is smaller than the size of the symbol.
- Fig. 3.
Transaxial small animal PET images of nude mice bearing human melanoma xenografts. Images were acquired 90 min after injection of approximately 5.5 MBq of [18F]Galacto-RGD. The top left image shows selective accumulation of the tracer in the αvβ3-positve (M21) tumor on the left flank. In contrast, no focal tracer accumulation is visible in the αvβ3-negative (M21-L) control tumor (bottom left image). The three images on the right were obtained from serial [18F]Galacto-RGD PET studies in one mouse. These illustrate the dose-dependent blockade of tracer uptake by the αv-selective cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Val-).
Tables
- Table 1
Biodistribution data for [18F]Galacto-RGD in melanoma-bearing nude mice and osteosarcoma-bearing mice
Values are given as % ID/g ± SD. Time p.i. (min) Osteosarcoma (αvβ3 positive) Melanoma M21 (αvβ3 positive) Melanoma M21-L (negative control) Blood 10 2.58 ± 0.41 2.93 ± 0.53 4.70a 60 0.27 ± 0.06 0.18 ± 0.06 0.26 ± 0.06 120 0.13 ± 0.03 0.05 ± 0.01 0.13 ± 0.07 Serum 10 5.25 ± 0.33 5.65 ± 0.89 8.71 60 0.50 ± 0.12 0.34 ± 0.11 0.49 ± 0.11 120 0.19 ± 0.04 0.09 ± 0.01 0.22 ± 0.10 Liver 10 5.47 ± 0.11 5.64 ± 2.27 6.40 60 2.94 ± 0.27 1.85 ± 0.39 2.07 ± 0.20 120 1.97 ± 0.27 1.25 ± 0.05 1.79 ± 0.58 Kidneys 10 8.67 ± 0.52 8.48 ± 0.84 10.82 60 3.11 ± 0.60 1.86 ± 0.10 2.24 ± 0.21 120 2.21 ± 0.46 1.52 ± 0.10 1.86 ± 0.46 Muscle 10 0.80 ± 0.13 1.13 ± 0.18 1.44 60 0.32 ± 0.06 0.21 ± 0.02 0.21 ± 0.03 120 0.28 ± 0.02 0.15 ± 0.02 0.18 ± 0.03 Spleen 10 2.54 ± 0.07 2.10 ± 0.45 2.39 60 1.54 ± 0.22 0.69 ± 0.10 0.77 ± 0.02 120 1.20 ± 0.04 0.64 ± 0.09 0.73 ± 0.14 Heart 10 1.94 ± 0.05 1.85 ± 0.24 2.02 60 0.51 ± 0.07 0.28 ± 0.05 0.34 ± 0.02 120 0.63 ± 0.41 0.19 ± 0.04 0.29 ± 0.06 Tumor 10 2.88 ± 0.32 3.90 ± 1.36 1.88 60 1.33 ± 0.20 1.56 ± 0.15 0.42 ± 0.09 120 1.68 ± 0.49 1.49 ± 0.10 0.44 ± 0.24 Lung 10 3.43 ± 0.24 3.64 ± 0.52 4.84 60 1.10 ± 0.18 0.76 ± 0.09 0.83 ± 0.08 120 0.72 ± 0.15 0.53 ± 0.05 0.71 ± 0.24 Femur 10 1.22 ± 0.04 1.51 ± 0.34 1.46 60 0.54 ± 0.11 0.34 ± 0.05 0.44 ± 0.06 120 0.51 ± 0.02 0.33 ± 0.02 0.50 ± 0.10 Colon 10 3.77 ± 0.16 1.74 ± 0.55 1.68 60 2.27 ± 1.23 0.57 ± 0.04 0.70 ± 0.19 120 1.59 ± 0.46 3.53 ± 0.44 0.76 ± 0.27 Brain 10 0.14 ± 0.01 0.19 ± 0.04 0.19 60 0.06 ± 0.01 0.05 ± 0.01 0.05 ± 0.01 120 0.05 ± 0.01 0.04 ± 0.01 0.05 ± 0.01 -
a Data for this time point result from one mouse.
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Volume 61, Issue 5
