Article Figures & Data
Figures
- Fig. 1.
A, FLT-PET of patient 15 with NSCLC with high proliferation fraction and increased FLT uptake (SUV, 6.38) in the tumor margin (70% stained nuclei in the tumor margin, right). Middle, transverse sections of PET and spiral CT. B, patient 12 with a low proliferating NSCLC (25% stained nuclei, right). FLT-PET (left) shows moderate FLT-uptake (SUV, 1.11). Middle, corresponding transverse sections of the spiral CT.
- Fig. 2.
Linear regression analysis demonstrates a significant correlation between proliferative fraction and FLT uptake in SPN. ○, NSCLC; ⋄, patient 16 with a carcinoma in situ (NSCLC) negative on FLT-PET; ▿, other malignant lesions.
Tables
- Table 1
Patient and tumor characteristics
Patient no. Age Sex Histopathology TNM SUV-FLT mean SUV-FLT max Ki-67 index 1 57 F NSCLC T1N1M0 5.63 8.7 65% 2 53 M NSCLC T2N1M0 4.02 5 41% 3 77 F NSCLC T2N1M0 3.98 5.3 43% 4 71 F NSCLC T2N1M0 2.9 4.4 35% 5 75 M NSCLC T2bN0M0 3.06 5.7 54% 6 53 F NSCLC T2N1M0 Neg. Neg. 10% 7 61 M NSCLC T3N0M0 4.89 6.8 45% 8 66 M NSCLC T1N0M0 3.24 4.7 26% 9 76 M NSCLC T4N2M0 3.05 5.2 35% 10 55 M NSCLC T2N2Mx 3.88 5.6 40% 11 62 F NSCLC TxN0M0 2.26 3.3 10% 12 55 M NSCLC T1N1M0 1.11 1.3 12% 13 51 F NSCLC T2N2M1 3.64 6.10 43% 14 60 M NSCLC T4N1M0 5.62 8.2 40% 15 56 F NSCLC T3N3M0 6.38 10.4 70% 16 67 M NSCLC (carcinoma in situ) T1N0M0 Neg. Neg. 32% 17 66 M SCLC T4N2M0 1.69 2.4 20% 18 50 M Non-Hodgkin’s lymphoma T2N0M0 2.53 4.2 12% 19 68 M Colorectal cancer, pulmonary met rTxN0M1 Neg. Neg. 12% 20 51 M Renal cell carcinoma, pulmonary met rTxN0M1 2.07 3.4 23% 21 65 M Renal cell carcinoma, pulmonary met rTxN0M1 1.32 1.9 10% 22 37 F Osteosarcoma, pulmonary met TxN0M1 0.816 1 1% 23 75 M Bronchiolitis - Neg. Neg. 0% 24 76 M 2×3 cm nodule, clinical course indicated benign lesion - Neg. Neg. 0% 25 51 F Tuberculoma - Neg. Neg. 5% 26 59 M Bronchiolitis - Neg. Neg. 0% 27 69 M Bronchiolitis - Neg. Neg. 0% 28 67 M 1×2 cm nodule, clinical course indicated benign lesion - Neg. Neg. 0% 29 55 F Fibroma - Neg. Neg. 0% 30 56 M Bronchopulmonary chondroma - Neg. Neg. 0%
June 2002
Volume 62, Issue 12
Volume 62, Issue 12
3-Deoxy-3-[18F]Fluorothymidine-Positron Emission Tomography for Noninvasive Assessment of Proliferation in Pulmonary Nodules
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