In the article by P. A. Masso-Welsh et al., entitled “Inhibition of Angiogenesis by the Cancer Chemopreventive Agent Conjugated Linoleic Acid,” which appeared in the August 1, 2002 issue of Cancer Research (), Figure 6I ⇓ appeared incorrectly. The correct figure ⇓ and corresponding legend appear below.
In the discussion, on page 4388, under the section entitled “Direct, isomer-specific effects of CLA on endothelial precursors,” the sentence which states “The trans-10, cis-12 CLA isomer was slightly more effective at 75 μM” should be changed to read "The cis-9, trans-11 CLA isomer was slightly more effective 75 μM.”
Patricia A. Masso-Welch
Danilo Zangani
Clement Ip
Mary M. Vaughan
Suzanne Shoemaker
Robert A. Ramirez
Margot M. Ip
Isomer dependence of CLA effects on endothelial differentiation in vitro. The effect of purified isomers of cis-9, trans-11 CLA and trans-10, cis-12 CLA and mixed isomers to affect microcapillary network formation by stromal vascular percursors was compared. A–D, MTT staining of wells, showing individual networks formed by mammary stromal cells cultured on EHS. This dye is metabolized by viable cells; the total number of networks is decreased by all CLA isomers [100 μM of mixed (B), cis-9, trans-11 (C), and trans-10, cis-12 CLA (D)] tested, compared with control with no CLA (A). In addition to reducing the number of colonies, all CLA isomers (F–H) induced changes in mammary stromal cell capillary network morphology, with a darkening of the colony compared with control with no CLA and decreased branching compared with control (E). I, results of quantitation of the size (average diameter) of the branching microcapillary networks. *, statistically significant differences from control (no CLA). Each column represents the mean of 15 colonies from each treatment and concentration; bars, SE. Bars: E–H, 200 μM.
- ©2002 American Association for Cancer Research.
Volume 62, Issue 19
