Cancer Research: 62 (20)

Advances in Brief

Advances in Brief

Transforming Growth Factor-β1 Mediates Cellular Response to DNA Damage in Situ

Kenneth B. Ewan, Rhonda L. Henshall-Powell, Shraddha A. Ravani, Maria Jose Pajares, Carlos Arteaga, Ray Warters, Rosemary J. Akhurst and Mary Helen Barcellos-Hoff

Cancer Res October 15 2002 62 (20) 5627-5631;
Advances in Brief

p300 Mediates Androgen-independent Transactivation of the Androgen Receptor by Interleukin 6

Jose D. Debes, Lucy J. Schmidt, Haojie Huang and Donald J. Tindall

Cancer Res October 15 2002 62 (20) 5632-5636;
Advances in Brief

Hypermethylation of HPP1 Is Associated with hMLH1 Hypermethylation in Gastric Adenocarcinomas

David M. Shibata, Fumiaki Sato, Yuriko Mori, Kellie Perry, Jing Yin, Suna Wang, Yan Xu, Andreea Olaru, Florin Selaru, Kevin Spring, Joanne Young, John M. Abraham and Stephen J. Meltzer

Cancer Res October 15 2002 62 (20) 5637-5640;
Advances in Brief

Hypermutable Bases in the p53 Cancer Gene Are at Vulnerable Positions in DNA Secondary Structures

Barbara E. Wright, Jacqueline M. Reimers, Karen H. Schmidt and Dennis K. Reschke

Cancer Res October 15 2002 62 (20) 5641-5644;
Advances in Brief

Activated Mammalian Target of Rapamycin Pathway in the Pathogenesis of Tuberous Sclerosis Complex Renal Tumors

Heidi L. Kenerson, Lauri D. Aicher, Lawrence D. True and Raymond S. Yeung

Cancer Res October 15 2002 62 (20) 5645-5650;
Advances in Brief

Isolation of a Novel Human Gene, APCDD1, as a Direct Target of the β-Catenin/T-Cell Factor 4 Complex with Probable Involvement in Colorectal Carcinogenesis

Meiko Takahashi, Manabu Fujita, Yoichi Furukawa, Ryuji Hamamoto, Takashi Shimokawa, Nobutomo Miwa, Michio Ogawa and Yusuke Nakamura

Cancer Res October 15 2002 62 (20) 5651-5656;
Advances in Brief

The Use of Interleukin 12-secreting Neural Stem Cells for the Treatment of Intracranial Glioma

Moneeb Ehtesham, Peter Kabos, Andrea Kabosova, Toomas Neuman, Keith L. Black and John S. Yu

Cancer Res October 15 2002 62 (20) 5657-5663;
Advances in Brief

Identical T-cell Receptor Transcripts in Multiple Melanoma Metastases

David Schrama, Eva Fuchs, Eva-Bettina Bröcker, Per thor Straten and Jürgen C. Becker

Cancer Res October 15 2002 62 (20) 5664-5667;
Advances in Brief

A Novel Mechanism of Nuclear Factor κB Activation through the Binding between Inhibitor of Nuclear Factor-κBα and the Processed NH₂-terminal Region of Mig-6

Toshiyuki Tsunoda, Junichi Inokuchi, Iwai Baba, Koji Okumura, Seiji Naito, Takehiko Sasazuki and Senji Shirasawa

Cancer Res October 15 2002 62 (20) 5668-5671;

Biochemistry and Biophysics

Biochemistry and Biophysics

Measurement by Nuclear Magnetic Resonance Diffusion of the Dimensions of the Mobile Lipid Compartment in C6 Cells

Yolanda Pérez, Hana Lahrech, Miquel E. Cabañas, Ramon Barnadas, Manel Sabés, Chantal Rémy and Carles Arús

Cancer Res October 15 2002 62 (20) 5672-5677;
Biochemistry and Biophysics

Sudan I Is a Potential Carcinogen for Humans

Marie Stiborová, Václav Martínek, Helena Rýdlová, Petr Hodek and Eva Frei

Cancer Res October 15 2002 62 (20) 5678-5684;

Carcinogenesis

Carcinogenesis

Overexpression of Glutamine Synthetase Is Associated with β-Catenin-Mutations in Mouse Liver Tumors during Promotion of Hepatocarcinogenesis by Phenobarbital

Sandra Loeppen, Daniela Schneider, Frank Gaunitz, Rolf Gebhardt, Raffael Kurek, Albrecht Buchmann and Michael Schwarz

Cancer Res October 15 2002 62 (20) 5685-5688;
Carcinogenesis

Ultraviolet-induced Phosphorylation of p70^S6K at Thr³⁸⁹ and Thr⁴²¹/Ser⁴²⁴ Involves Hydrogen Peroxide and Mammalian Target of Rapamycin but not Akt and Atypical Protein Kinase C

Chuanshu Huang, Jingxia Li, Qingdong Ke, Stephen S. Leonard, Bing-Hua Jiang, Xiao-Song Zhong, Max Costa, Vincent Castranova and Xianglin Shi

Cancer Res October 15 2002 62 (20) 5689-5697;

Clinical Investigations

Clinical Investigations

Assessment of Proliferation in Vivo Using 2-[¹¹C]Thymidine Positron Emission Tomography in Advanced Intra-abdominal Malignancies

Paula Wells, Roger N. Gunn, Malcolm Alison, Colin Steel, Mathew Golding, Alex S. Ranicar, Frank Brady, Safiye Osman, Terry Jones and Pat Price

Cancer Res October 15 2002 62 (20) 5698-5702;

Experimental Therapeutics

Experimental Therapeutics

Enhanced Sensitization to Taxol-induced Apoptosis by Herceptin Pretreatment in ErbB2-overexpressing Breast Cancer Cells

Sangkyou Lee, Wentao Yang, Keng-Hsueh Lan, Shankar Sellappan, Kristine Klos, Gabriel Hortobagyi, Mien-Chie Hung and Dihua Yu

Cancer Res October 15 2002 62 (20) 5703-5710;
Experimental Therapeutics

Benzylamide Sulindac Analogues Induce Changes in Cell Shape, Loss of Microtubules and G₂-M Arrest in a Chronic Lymphocytic Leukemia (CLL) Cell Line and Apoptosis in Primary CLL Cells

Eun-Yi Moon and Adam Lerner

Cancer Res October 15 2002 62 (20) 5711-5719;
Experimental Therapeutics

Inhibition of Growth and Metastasis of Orthotopic Human Prostate Cancer in Athymic Mice by Combination Therapy with Pegylated Interferon-α-2b and Docetaxel

Samuel F. Huang, Sun-Jin Kim, Anh T. Lee, Takashi Karashima, Cora Bucana, Daniel Kedar, Paul Sweeney, Badar Mian, Dominic Fan, David Shepherd, Isaiah J. Fidler, Colin P. Dinney and Jerald J. Killion

Cancer Res October 15 2002 62 (20) 5720-5726;
Experimental Therapeutics

Combined Therapy of Local and Metastatic 4T1 Breast Tumor in Mice Using SU6668, an Inhibitor of Angiogenic Receptor Tyrosine Kinases, and the Immunostimulator B7.2-IgG Fusion Protein

Xiaojun Huang, Michael K. Wong, Huiming Yi, Simon Watkins, A. Douglas Laird, Stanley F. Wolf and Elieser Gorelik

Cancer Res October 15 2002 62 (20) 5727-5735;
Experimental Therapeutics

Potential of the Conditionally Replicative Adenovirus Ad5-Δ24RGD in the Treatment of Malignant Gliomas and Its Enhanced Effect with Radiotherapy

Martine L. M. Lamfers, Jacques Grill, Clemens M. F. Dirven, Victor W. van Beusechem, Birgit Geoerger, Jaap van den Berg, Ramon Alemany, Juan Fueyo, David T. Curiel, Gilles Vassal, Herbert M. Pinedo, W. Peter Vandertop and Winald R. Gerritsen

Cancer Res October 15 2002 62 (20) 5736-5742;
Experimental Therapeutics

UCN-01 Inhibits p53 Up-Regulation and Abrogates γ-Radiation-induced G₂-M Checkpoint Independently of p53 by Targeting Both of the Checkpoint Kinases, Chk2 and Chk1

Qiang Yu, JiHyun La Rose, Hongliang Zhang, Haruyuki Takemura, Kurt W. Kohn and Yves Pommier

Cancer Res October 15 2002 62 (20) 5743-5748;
Experimental Therapeutics

ZD1839 (Iressa)

Alan E. Wakeling, Simon P. Guy, Jim R. Woodburn, Susan E. Ashton, Brenda J. Curry, Andrew J. Barker and Keith H. Gibson

Cancer Res October 15 2002 62 (20) 5749-5754;
Experimental Therapeutics

Radioimmunotherapy of A431 Xenografted Mice with Pretargeted B3 Antibody-Streptavidin and ⁹⁰Y-labeled 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-tetraacetic Acid (DOTA)-Biotin

Zhengsheng Yao, Meili Zhang, Donald B. Axworthy, Karen J. Wong, Kayhan Garmestani, Luke Park, Chang W. Park, Robert W. Mallett, Louis J. Theodore, Eric K. Yau, Thomas A. Waldmann, Martin W. Brechbiel, Chang H. Paik, Ira Pastan and Jorge A. Carrasquillo

Cancer Res October 15 2002 62 (20) 5755-5760;
Experimental Therapeutics

Molecular Characterization and Sensitivity of STI-571 (Imatinib Mesylate, Gleevec)-resistant, Bcr-Abl-positive, Human Acute Leukemia Cells to SRC Kinase Inhibitor PD180970 and 17-Allylamino-17-demethoxygeldanamycin

Ramadevi Nimmanapalli, Erica O’Bryan, Mei Huang, Purva Bali, Pearlie Kay Burnette, Thomas Loughran, James Tepperberg, Richard Jove and Kapil Bhalla

Cancer Res October 15 2002 62 (20) 5761-5769;
Experimental Therapeutics

Vector-based Vaccine/Cytokine Combination Therapy to Enhance Induction of Immune Responses to a Self-Antigen and Antitumor Activity

Wilhelmina M. Aarts, Jeffrey Schlom and James W. Hodge

Cancer Res October 15 2002 62 (20) 5770-5777;
Experimental Therapeutics

Cyclooxygenase-2 Inhibition with Celecoxib Enhances Antitumor Efficacy and Reduces Diarrhea Side Effect of CPT-11

Ovidiu C. Trifan, William F. Durham, Valerie S. Salazar, Jennifer Horton, Benjamin D. Levine, Ben S. Zweifel, Thomas W. Davis and Jaime L. Masferrer

Cancer Res October 15 2002 62 (20) 5778-5784;

Immunology

Immunology

Visualization of Effective Tumor Targeting by CD8+ Natural Killer T Cells Redirected with Bispecific Antibody F(ab′)₂HER2xCD3

Christian Scheffold, Martin Kornacker, Yolanda C. Scheffold, Christopher H. Contag and Robert S. Negrin

Cancer Res October 15 2002 62 (20) 5785-5791;
Immunology

Establishment of an HLA-A*0201 Human Papillomavirus Type 16 Tumor Model to Determine the Efficacy of Vaccination Strategies in HLA-A*0201 Transgenic Mice

Gretchen L. Eiben, Markwin P. Velders, Hans Schreiber, Maria Cristina Cassetti, Jeffrey K. Pullen, Larry R. Smith and W. Martin Kast

Cancer Res October 15 2002 62 (20) 5792-5799;
Immunology

Effects of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Alone and in Combination with Chemotherapeutic Agents on Patients’ Colon Tumors Grown in SCID Mice

Takuji Naka, Kenji Sugamura, Bonnie L. Hylander, Michael B. Widmer, Youcef M. Rustum and Elizabeth A. Repasky

Cancer Res October 15 2002 62 (20) 5800-5806;
Immunology

Recognition of Prostate Tumor Cells by Cytotoxic T Lymphocytes Specific for Prostate-specific Membrane Antigen

Jun Lu and Esteban Celis

Cancer Res October 15 2002 62 (20) 5807-5812;
Immunology

Impaired Antibody-dependent Cellular Cytotoxicity Mediated by Herceptin in Patients with Gastric Cancer

Koji Kono, Akihiro Takahashi, Fumiko Ichihara, Hidemitsu Sugai, Hideki Fujii and Yoshirou Matsumoto

Cancer Res October 15 2002 62 (20) 5813-5817;
Immunology

Integrated Functional Genomics Approach for the Design of Patient-individual Antitumor Vaccines

Toni Weinschenk, Cécile Gouttefangeas, Markus Schirle, Florian Obermayr, Steffen Walter, Oliver Schoor, Raffael Kurek, Wolfgang Loeser, Karl-Horst Bichler, Dorothee Wernet, Stefan Stevanović and Hans-Georg Rammensee

Cancer Res October 15 2002 62 (20) 5818-5827;
Immunology

Susceptibility to Lymphoid Neoplasia in Immunodeficient Strains of Nonobese Diabetic Mice

Priscilla P. L. Chiu, Evgueni Ivakine, Steven Mortin-Toth and Jayne S. Danska

Cancer Res October 15 2002 62 (20) 5828-5834;
Immunology

Direct Detection and Quantitation of a Distinct T-Cell Epitope Derived from Tumor-specific Epithelial Cell-associated Mucin Using Human Recombinant Antibodies Endowed with the Antigen-specific, Major Histocompatibility Complex-restricted Specificity of T Cells

Cyril J. Cohen, Noa Hoffmann, Marganit Farago, Hennie R. Hoogenboom, Lea Eisenbach and Yoram Reiter

Cancer Res October 15 2002 62 (20) 5835-5844;
Immunology

Immunogenicity of a Plasmid DNA Vaccine Encoding Chimeric Idiotype in Patients with B-Cell Lymphoma

John M. Timmerman, Gita Singh, Gary Hermanson, Peter Hobart, Debra K. Czerwinski, Behnaz Taidi, Ranjani Rajapaksa, Clemens B. Caspar, Adrienne van Beckhoven and Ronald Levy

Cancer Res October 15 2002 62 (20) 5845-5852;
Immunology

Interleukin 18 Gene Transfer Expands the Repertoire of Antitumor Th1-type Immunity Elicited by Dendritic Cell-based Vaccines in Association with Enhanced Therapeutic Efficacy

Tomohide Tatsumi, Andrea Gambotto, Paul D. Robbins and Walter J. Storkus

Cancer Res October 15 2002 62 (20) 5853-5858;

Molecular Biology and Genetics

Molecular Biology and Genetics

Genome-wide Analysis of Gene Expression in Synovial Sarcomas Using a cDNA Microarray

Satoshi Nagayama, Toyomasa Katagiri, Tatsuhiko Tsunoda, Taisuke Hosaka, Yasuaki Nakashima, Nobuhito Araki, Katsuyuki Kusuzaki, Tomitaka Nakayama, Tadao Tsuboyama, Takashi Nakamura, Masayuki Imamura, Yusuke Nakamura and Junya Toguchida

Cancer Res October 15 2002 62 (20) 5859-5866;
Molecular Biology and Genetics

Comparative Gene Expression Profile Analysis of GLI and c-MYC in an Epithelial Model of Malignant Transformation

Iúri D. Louro, Evans C. Bailey, Xingnan Li, Lindsey S. South, Peggy R. McKie-Bell, Bradley K. Yoder, Conway C. Huang, Martin R. Johnson, Aubrey E. Hill, Ronald L. Johnson and J. Michael Ruppert

Cancer Res October 15 2002 62 (20) 5867-5873;
Molecular Biology and Genetics

SLIT2, a Human Homologue of the Drosophila Slit2 Gene, Has Tumor Suppressor Activity and Is Frequently Inactivated in Lung and Breast Cancers

Ashraf Dallol, Nancy Fernandes Da Silva, Paolo Viacava, John D. Minna, Ivan Bieche, Eamonn R. Maher and Farida Latif

Cancer Res October 15 2002 62 (20) 5874-5880;
Molecular Biology and Genetics

High Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (iPFK-2; PFKFB3) in Human Cancers

Toshiya Atsumi, Jason Chesney, Christine Metz, Lin Leng, Seamas Donnelly, Zenji Makita, Robert Mitchell and Richard Bucala

Cancer Res October 15 2002 62 (20) 5881-5887;
Molecular Biology and Genetics

An Antisense Oligonucleotide Targeted to Human Ku86 Messenger RNA Sensitizes M059K Malignant Glioma Cells to Ionizing Radiation, Bleomycin, and Etoposide but not DNA Cross-Linking Agents

Alexandre I. Belenkov, Jean-Pierre Paiement, Lawrence C. Panasci, Brett P. Monia and Terry Y. K. Chow

Cancer Res October 15 2002 62 (20) 5888-5896;
Molecular Biology and Genetics

Deregulation of Caspase 8 and 10 Expression in Pediatric Tumors and Cell Lines

Kenichi Harada, Shinichi Toyooka, Narayan Shivapurkar, Anirban Maitra, Jyotsna L. Reddy, Hittu Matta, Kuniharu Miyajima, Charles F. Timmons, Gail E. Tomlinson, Domenico Mastrangelo, Robert J. Hay, Preet M. Chaudhary and Adi F. Gazdar

Cancer Res October 15 2002 62 (20) 5897-5901;
Molecular Biology and Genetics

Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer

Manel Esteller, Mingzhou Guo, Victor Moreno, Miquel Angel Peinado, Gabriel Capella, Oliver Galm, Stephen B. Baylin and James G. Herman

Cancer Res October 15 2002 62 (20) 5902-5905;
Molecular Biology and Genetics

Biallelic Epigenetic Inactivation of the RASSF1A Tumor Suppressor Gene in Medulloblastoma Development

Meryl E. Lusher, Janet C. Lindsey, Farida Latif, Andrew D. J. Pearson, David W. Ellison and Steven C. Clifford

Cancer Res October 15 2002 62 (20) 5906-5911;

Tumor Biology

Tumor Biology

The Development of [¹²⁴I]Iodinated-VG76e

David R. Collingridge, Veronica A. Carroll, Mathias Glaser, Eric O. Aboagye, Safiye Osman, Oliver C. Hutchinson, Henryk Barthel, Sajinder K. Luthra, Frank Brady, Roy Bicknell, Pat Price and Adrian L. Harris

Cancer Res October 15 2002 62 (20) 5912-5919;
Tumor Biology

Identification of the Human PHLDA1/TDAG51 Gene

Rüdiger Neef, Martina A. Kuske, Elma Pröls and Judith P. Johnson

Cancer Res October 15 2002 62 (20) 5920-5929;
Tumor Biology

Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer

Chris J. Scotton, Julia L. Wilson, Kate Scott, Gordon Stamp, George D. Wilbanks, Simon Fricker, Gary Bridger and Frances R. Balkwill

Cancer Res October 15 2002 62 (20) 5930-5938;
Tumor Biology

Dissecting Karyotypic Patterns in Colorectal Tumors

Mattias Höglund, David Gisselsson, Gunnar B. Hansen, Torbjörn Säll, Felix Mitelman and Mef Nilbert

Cancer Res October 15 2002 62 (20) 5939-5946;
Tumor Biology

PML Is a Target Gene of β-Catenin and Plakoglobin, and Coactivates β-Catenin-mediated Transcription

Michael Shtutman, Jacob Zhurinsky, Moshe Oren, Elina Levina and Avri Ben-Ze’ev

Cancer Res October 15 2002 62 (20) 5947-5954;
Tumor Biology

Compound Disruption of Smad2 Accelerates Malignant Progression of Intestinal Tumors in Apc Knockout Mice

Toshiaki Hamamoto, Hideyuki Beppu, Hitoshi Okada, Masahiro Kawabata, Tadaichi Kitamura, Kohei Miyazono and Mitsuyasu Kato

Cancer Res October 15 2002 62 (20) 5955-5961;
Tumor Biology

Down-Regulation of COOH-Terminal Binding Protein Expression in Malignant Melanomas Leads to Induction of MIA Expression

Ina Poser, Michaela Golob, Michael Weidner, Reinhard Buettner and Anja K. Bosserhoff

Cancer Res October 15 2002 62 (20) 5962-5966;
Tumor Biology

Organ Heterogeneity of Host-derived Matrix Metalloproteinase Expression and Its Involvement in Multiple-Organ Metastasis by Lung Cancer Cell Lines

Minoru Shiraga, Seiji Yano, Akihiko Yamamoto, Hirohisa Ogawa, Hisatsugu Goto, Toyokazu Miki, Keisuke Miki, Helong Zhang and Saburo Sone

Cancer Res October 15 2002 62 (20) 5967-5973;
Tumor Biology

Preoperative Blood Reverse Transcriptase-PCR Assays for Prostate-specific Antigen and Human Glandular Kallikrein for Prediction of Prostate Cancer Progression after Radical Prostatectomy

Shahrokh F. Shariat, Emanuel Gottenger, Cuong Nguyen, Weitao Song, Michael W. Kattan, John Andenoro, Thomas M. Wheeler, David M. Spencer and Kevin M. Slawin

Cancer Res October 15 2002 62 (20) 5974-5979;
Tumor Biology

Genome-wide Allelotyping of a New in Vitro Model System Reveals Early Events in Breast Cancer Progression

Zheng Li, Zhen Hang Meng, Aejaz Sayeed, Refaat Shalaby, Britt-Marie Ljung and Shanaz H. Dairkee

Cancer Res October 15 2002 62 (20) 5980-5987;

Letters to the Editor

Letters to the Editor

Correspondence re: P. Laiho et al., Low-Level Microsatellite Instability in Most Colorectal Carcinomas. Cancer Res., 62: 1166–1170, 2002.

Jeremy R. Jass, Vicki L. J. Whitehall, Joanne Young, Barbara Leggett, Stephen J. Meltzer, Nagahide Matsubara and Richard Fishel

Cancer Res October 15 2002 62 (20) 5988-5990;

Erratum

Cancer Res October 15 2002 62 (20) 5992-5992;

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Advances in Brief

Biochemistry and Biophysics

Carcinogenesis

Clinical Investigations

Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

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